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CHEBI:16015 ChEBI 30572 ChemSpider P0ABQ4 UniProt 6022 PubChem-compound 17215925 ChemSpider SMILES NC1=NC(=O)C2=C(NCC(=N2)C(O)C(O)CO)N1 7057990 PubChem-compound 937 ChemSpider P08192 UniProt HMDB0012199 HMDB GTP cyclohydrolase 1 Para-aminobenzoate synthase glutamine amidotransferase component II SMILES O Pyrophosphate C10H14N5O7P Adenosine monophosphate 347.06308 1.0 HMDB0002275 HMDB C00568 KEGG Compound CHEBI:20506 ChEBI CHEBI:16027 ChEBI Chorismate Biosynthesis SubPathway C9H12N5O7P 7,8-dihydroneopterin 3'-phosphate 333.04742 HMDB0000538 HMDB C9H12N5O13P3 7,8-dihydroneopterin 3'-triphosphate 490.96664 DIHYDROXYPHENYLGLYCOLALDEHYDE BioCyc ATP BioCyc C19H19N7O6 7,8-dihydrofolate monoglutamate 441.14078 5961 PubChem-compound 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase 1.0 40480038 PubChem-compound 1.0 1.0 18714427 ChemSpider 1.0 559142 ChemSpider Pyruvic acid ADP BioCyc Dihydroneopterin triphosphate pyrophosphatase C3H4O3 Pyruvic acid 88.016045 (2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl diphosphate 6-hydroxymethyl-7,8-dihydropterin 53-59-8 CAS 5746 ChemSpider 1.0 4-amino-4-deoxychorismate 5742 ChemSpider 1038 PubChem-compound 953 ChemSpider CHEBI:16474 ChEBI Dihydrofolate reductase folM SMILES O[C@@H]1C=CC(=C[C@H]1OC(=C)C(O)=O)C(O)=O 278 ChemSpider C19H23N7O6 Tetrahydrofolic acid 445.171 Adenosine monophosphate 25245170 PubChem-compound 1.0 SMP0001750 SMPDB 5858 ChemSpider O4P Phosphate 94.95342 Para-aminobenzoate synthase component 1 Bifunctional protein folC NADPH 6830 PubChem-compound CHEBI:17333 ChEBI 1010 ChemSpider DIHYDRONEOPTERIN-P3 BioCyc Aminodeoxychorismate lyase C00101 KEGG Compound 1.0 HMDB0001412 HMDB CHEBI:4581 ChEBI NADP PPI BioCyc C21H30N7O17P3 NADPH 745.0911 SMILES NC1=NC2=C(N=C(CNC3=CC=C(C=C3)C(O)=O)CN2)C(=O)N1 C21H29N7O17P3 NADP 744.08325 THF BioCyc 1.0 1.0 NADPH BioCyc C10H16N5O14P3 Guanosine triphosphate 522.99066 Hydrogen Ion C5H10N2O3 L-Glutamine 146.06914 Adenosine triphosphate SMILES NC1=NC(=O)C2=C(NC[C@H](CNC3=CC=C(C=C3)C(=O)NC(CCC(O)=O)C(O)=O)N2)N1 CHEBI:58406 ChEBI L-Glutamic acid SMILES [O-]P([O-])([O-])=O 1.0 HMDB0000217 HMDB Formic acid C00009 KEGG Compound C00921 KEGG Compound C00008 KEGG Compound C00006 KEGG Compound 1.0 CHEBI:18009 ChEBI C00001 KEGG Compound HMDB0001429 HMDB Para-aminobenzoate synthase glutamine amidotransferase component II CHEBI:18361 ChEBI C00005 KEGG Compound CHEBI:18367 ChEBI 141-46-8 CAS 1032 ChemSpider 135-16-0 CAS GTP cyclohydrolase 1 C00002 KEGG Compound 1031 ChemSpider SMILES NC(=O)C1=C[N+](=CC=C1)[C@@H]1O[C@H](CO[P@](O)(=O)O[P@](O)(=O)OC[C@H]2O[C@H]([C@H](OP(O)(O)=O)[C@@H]2O)N2C=NC3=C(N)N=CN=C23)[C@@H](O)[C@H]1O HMDB0000221 HMDB Dihydroneopterin triphosphate pyrophosphatase Glycolaldehyde SMILES NC(=O)C1=CN(C=CC1)[C@H]1O[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]2O[C@@H]([C@@H](OP(O)(O)=O)[C@H]2O)N2C=NC3=C(N)N=CN=C23)[C@H](O)[C@@H]1O C2H4O2 Glycolaldehyde 60.02113 150-13-0 CAS GLN BioCyc GLT BioCyc Dihydrofolate reductase PW001735 PathWhiz GTP cyclohydrolase I 53-57-6 CAS P26281 UniProt Purine Nucleotides De Novo Biosynthesis SubPathway Folate Biosynthesis C00251 KEGG Compound 7,8-dihydroneopterin 3'-triphosphate 7,8-dihydrofolate monoglutamate C00013 KEGG Compound 7,8-dihydroneopterin 3'-phosphate CHEBI:17001 ChEBI O7P2 Pyrophosphate 173.91193 4-amino-4-deoxychorismate synthase dihydropteroate synthase NAD(P) BioCyc dihydroneopterin aldolase 1.0 5957 PubChem-compound Dihydropteroate synthase 562 TAXONOMY Dihydroneopterin aldolase H Hydrogen Ion 1.007825 P0AC13 UniProt CHEBI:15996 ChEBI P0AC16 UniProt C00022 KEGG Compound L-Glutamine 56-65-5 CAS C00020 KEGG Compound C00025 KEGG Compound Dihydrofolate reductase folM Guanosine triphosphate C00266 KEGG Compound HMDB0000243 HMDB Adenosine diphosphate P00903 UniProt C10H15N5O10P2 Adenosine diphosphate 427.02942 1.0 SMP0000925 SMPDB Para-aminobenzoate synthase component 1 CPD-8587 BioCyc C04874 KEGG Compound SMP0000927 SMPDB 4.1.2.25 false 4.1.2.25 7,8-Dihydroneopterin → 6-hydroxymethyl-7,8-dihydropterin + Glycolaldehyde LEFT_TO_RIGHT Reaction3398 false 7,8-dihydroneopterin 3'-phosphate + Water → 7,8-Dihydroneopterin + Phosphate LEFT_TO_RIGHT Water 3.6.1.- false 3.6.1.- 7,8-dihydroneopterin 3'-triphosphate + Water → 7,8-dihydroneopterin 3'-phosphate + Hydrogen Ion + Pyrophosphate LEFT_TO_RIGHT AMP BioCyc 3.5.4.16 false 3.5.4.16 Guanosine triphosphate + Water → 7,8-dihydroneopterin 3'-triphosphate + Formic acid + Hydrogen Ion LEFT_TO_RIGHT HMDB0000250 HMDB SMILES [O-]P([O-])(=O)OP([O-])([O-])=O 7,8-dihydropteroate BioCyc 14000-31-8 CAS HMDB0001341 HMDB 1218-98-0 CAS 756 PubChem-compound C00044 KEGG Compound 7,8-Dihydroneopterin C10H10O6 Chorismate 226.04774 5675 ChemSpider 56-85-9 CAS SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O Dihydrofolate reductase 1.0 CHEBI:17071 ChEBI HMDB0000148 HMDB 18971002 PubChem-compound C14H14N6O3 7,8-Dihydropteroic acid 314.11273 1.0 11542 ChemSpider HMDB0000142 HMDB 7,8-Dihydropteroic acid CHEBI:15422 ChEBI P0AFS3 UniProt Escherichia coli 7732-18-5 CAS 1.0 C00058 KEGG Compound Chorismate 1.0 61-19-8 CAS SMILES NC1=C2N=CN([C@@H]3O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]3O)C2=NC=N1 617-12-9 CAS CH2O2 Formic acid 46.005478 ReactionCatalysis3369 ACTIVATION 127-17-3 CAS Dihydroneopterin aldolase Dihydropteroate synthase 56-86-0 CAS P28305 UniProt ReactionCatalysis3364 ACTIVATION FORMATE BioCyc 10.0 ReactionCatalysis3367 ACTIVATION ReactionCatalysis3368 ACTIVATION ReactionCatalysis3365 ACTIVATION ReactionCatalysis3366 ACTIVATION C5H9NO4 L-Glutamic acid 147.05316 SMILES NC1=NC2=C(N=C(CO)CN2)C(=O)N1 1.0 33032 PubChem-compound SMP0000836 SMPDB SMILES OP(=O)(OCC1=NC2=C(NC1)NC(=N)N=C2[O-])OP([O-])([O-])=O SMILES [H][C@@]1(N)C=CC(=C[C@@]1([H])OC(=C)C([O-])=O)C(O)=O C10H16N5O13P3 Adenosine triphosphate 506.99576 ReactionCatalysis3370 ACTIVATION 1.0 659 PubChem-compound ReactionCatalysis3371 ACTIVATION C00064 KEGG Compound CHEBI:16761 ChEBI P0AFC0 UniProt 8.0 p-Aminobenzoic acid HMDB0000045 HMDB SMILES CC(=O)C(O)=O C7H7NO2 p-Aminobenzoic acid 137.04768 P-AMINO-BENZOATE BioCyc P0A6T5 UniProt 25201779 PubChem-compound ReactionCatalysis3372 ACTIVATION ReactionCatalysis3373 ACTIVATION 962 PubChem-compound CPD-9517 BioCyc 5800 ChemSpider 736 ChemSpider Phosphate P05041 UniProt 1.0 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase C00080 KEGG Compound CHEBI:30753 ChEBI Tetrahydrofolic acid CHEBI:30751 ChEBI 2.0 170 PubChem-compound HMDB0002111 HMDB CHEBI:32816 ChEBI SMILES N[C@@H](CCC(O)=O)C(O)=O PW000816 PathWhiz SMILES OC=O CHEBI:15377 ChEBI C10H10NO5 4-amino-4-deoxychorismate 224.05644 CHEBI:15378 ChEBI SMILES [H+] 14265-44-2 CAS C7H8N5O8P2 (2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl diphosphate 351.9848 C7H9N5O2 6-hydroxymethyl-7,8-dihydropterin 195.07562 PYRUVATE BioCyc 6569 ChemSpider 58-64-0 CAS SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O 5886 PubChem-compound GTP BioCyc SMILES NC1=CC=C(C=C1)C(O)=O 1.0 1.0 CHEBI:57602 ChEBI 165 ChemSpider HMDB0001392 HMDB HMDB0001273 HMDB 644102 PubChem-compound 6083 PubChem-compound SMILES NC1=NC2=C(N=CN2[C@@H]2O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]2O)C(=O)N1 639 ChemSpider 64-18-6 CAS SMILES N[C@@H](CCC(N)=O)C(O)=O C9H13N5O4 7,8-Dihydroneopterin 255.09676 2134-76-1 CAS SubPathwayInteraction1392 SubPathway1392Reaction SubPathwayReaction 22833512 PubChem-compound SubPathwayInteraction1391 SubPathwayReaction SubPathway1391Reaction Aminodeoxychorismate lyase 1.0 1.0 CHEBI:18050 ChEBI Bifunctional protein folC H2O Water 18.010565 CHEBI:17083 ChEBI PW000910 PathWhiz 86-01-1 CAS HMDB0003344 HMDB 1060 PubChem-compound 1061 PubChem-compound SMILES NC1=NC(=O)C2=C(NCC(=N2)C(O)C(O)COP([O-])(=O)OP([O-])(=O)OP([O-])([O-])=O)N1 HMDB0059597 HMDB HMDB0001846 HMDB SMILES [H][C@@](O)(COP(O)([O-])=O)[C@@]([H])(O)C1=NC2=C(NC1)NC(=N)N=C2[O-] 12039 PubChem-compound SMILES [H][C@@](CCC([O-])=O)(NC(=O)C1=CC=C(NCC2=NC3=C(NC2)NC(=N)N=C3[O-])C=C1)C(O)=O SubPathwayInteraction1398 SubPathway1398Reaction SubPathwayReaction PW000908 PathWhiz HMDB0000641 HMDB SMILES OCC=O 13781857 PubChem-compound 1.5.1.3 false 1.5.1.3 7,8-dihydrofolate monoglutamate + Hydrogen Ion + NADPH → NADP + Tetrahydrofolic acid LEFT_TO_RIGHT 6.3.2.17 false 6.3.2.17 7,8-Dihydropteroic acid + Adenosine triphosphate + L-Glutamic acid → 7,8-dihydrofolate monoglutamate + Adenosine diphosphate + Hydrogen Ion + Phosphate LEFT_TO_RIGHT 2.6.1.85 false 2.6.1.85 Chorismate + L-Glutamine → 4-amino-4-deoxychorismate + L-Glutamic acid LEFT_TO_RIGHT 4.1.3.38 false 4.1.3.38 4-amino-4-deoxychorismate → Hydrogen Ion + Pyruvic acid + p-Aminobenzoic acid LEFT_TO_RIGHT 2.5.1.15 false 2.5.1.15 (2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl diphosphate + p-Aminobenzoic acid → 7,8-Dihydropteroic acid + Pyrophosphate LEFT_TO_RIGHT 1.0 2.7.6.3 false 2.7.6.3 6-hydroxymethyl-7,8-dihydropterin + Adenosine triphosphate → (2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl diphosphate + Adenosine monophosphate + Hydrogen Ion LEFT_TO_RIGHT One Carbon Pool by Folate SubPathway GTP cyclohydrolase 1 Dihydroneopterin triphosphate pyrophosphatase Dihydroneopterin aldolase 2-amino-4- hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase Dihydropteroate synthase Aminodeoxychorismate lyase Para- aminobenzoate synthase component 1 Para- aminobenzoate synthase glutamine amidotransferase component II Dihydrofolate reductase folM Guanosine triphosphate H 2 O Formic acid H + 7,8- dihydroneopterin 3'-triphosphate H 2 O PP i H + 7,8- dihydroneopterin 3'-phosphate H 2 O P i 7,8- Dihydroneopterin Glycolaldehyde 6- hydroxymethyl- 7,8- dihydropterin ATP AMP H + (2-amino-4- hydroxy-7,8- dihydropteridin- 6-yl)methyl diphosphate p-Aminobenzoic acid PP i 7,8- Dihydropteroic acid 4-amino-4- deoxychorismate Pyruvic acid H + Chorismate L-Glutamine L-Glutamic acid ATP L-Glutamic acid ADP P i H + 7,8- dihydrofolate monoglutamate H + NADPH NADP Tetrahydrofolic acid Magnesium Magnesium Bifunctional protein folC Potassium Magnesium Chorismate Biosynthesis One Carbon Pool by Folate Purine Nucleotides De Novo Biosynthesis Dihydrofolate reductase Magnesium
CHEBI:16015 ChEBI 30572 ChemSpider P0ABQ4 UniProt 6022 PubChem-compound 17215925 ChemSpider SMILES NC1=NC(=O)C2=C(NCC(=N2)C(O)C(O)CO)N1 7057990 PubChem-compound 937 ChemSpider P08192 UniProt HMDB0012199 HMDB GTP cyclohydrolase 1 Para-aminobenzoate synthase glutamine amidotransferase component II SMILES O Pyrophosphate C10H14N5O7P Adenosine monophosphate 347.06308 1.0 HMDB0002275 HMDB C00568 KEGG Compound CHEBI:20506 ChEBI CHEBI:16027 ChEBI Chorismate Biosynthesis SubPathway C9H12N5O7P 7,8-dihydroneopterin 3'-phosphate 333.04742 HMDB0000538 HMDB C9H12N5O13P3 7,8-dihydroneopterin 3'-triphosphate 490.96664 DIHYDROXYPHENYLGLYCOLALDEHYDE BioCyc ATP BioCyc C19H19N7O6 7,8-dihydrofolate monoglutamate 441.14078 5961 PubChem-compound 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase 1.0 40480038 PubChem-compound 1.0 1.0 18714427 ChemSpider 1.0 559142 ChemSpider Pyruvic acid ADP BioCyc Dihydroneopterin triphosphate pyrophosphatase C3H4O3 Pyruvic acid 88.016045 (2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl diphosphate 6-hydroxymethyl-7,8-dihydropterin 53-59-8 CAS 5746 ChemSpider 1.0 4-amino-4-deoxychorismate 5742 ChemSpider 1038 PubChem-compound 953 ChemSpider CHEBI:16474 ChEBI Dihydrofolate reductase folM SMILES O[C@@H]1C=CC(=C[C@H]1OC(=C)C(O)=O)C(O)=O 278 ChemSpider C19H23N7O6 Tetrahydrofolic acid 445.171 Adenosine monophosphate 25245170 PubChem-compound 1.0 SMP0001750 SMPDB 5858 ChemSpider O4P Phosphate 94.95342 Para-aminobenzoate synthase component 1 Bifunctional protein folC NADPH 6830 PubChem-compound CHEBI:17333 ChEBI 1010 ChemSpider DIHYDRONEOPTERIN-P3 BioCyc Aminodeoxychorismate lyase C00101 KEGG Compound 1.0 HMDB0001412 HMDB CHEBI:4581 ChEBI NADP PPI BioCyc C21H30N7O17P3 NADPH 745.0911 SMILES NC1=NC2=C(N=C(CNC3=CC=C(C=C3)C(O)=O)CN2)C(=O)N1 C21H29N7O17P3 NADP 744.08325 THF BioCyc 1.0 1.0 NADPH BioCyc C10H16N5O14P3 Guanosine triphosphate 522.99066 Hydrogen Ion C5H10N2O3 L-Glutamine 146.06914 Adenosine triphosphate SMILES NC1=NC(=O)C2=C(NC[C@H](CNC3=CC=C(C=C3)C(=O)NC(CCC(O)=O)C(O)=O)N2)N1 CHEBI:58406 ChEBI L-Glutamic acid SMILES [O-]P([O-])([O-])=O 1.0 HMDB0000217 HMDB Formic acid C00009 KEGG Compound C00921 KEGG Compound C00008 KEGG Compound C00006 KEGG Compound 1.0 CHEBI:18009 ChEBI C00001 KEGG Compound HMDB0001429 HMDB Para-aminobenzoate synthase glutamine amidotransferase component II CHEBI:18361 ChEBI C00005 KEGG Compound CHEBI:18367 ChEBI 141-46-8 CAS 1032 ChemSpider 135-16-0 CAS GTP cyclohydrolase 1 C00002 KEGG Compound 1031 ChemSpider SMILES NC(=O)C1=C[N+](=CC=C1)[C@@H]1O[C@H](CO[P@](O)(=O)O[P@](O)(=O)OC[C@H]2O[C@H]([C@H](OP(O)(O)=O)[C@@H]2O)N2C=NC3=C(N)N=CN=C23)[C@@H](O)[C@H]1O HMDB0000221 HMDB Dihydroneopterin triphosphate pyrophosphatase Glycolaldehyde SMILES NC(=O)C1=CN(C=CC1)[C@H]1O[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]2O[C@@H]([C@@H](OP(O)(O)=O)[C@H]2O)N2C=NC3=C(N)N=CN=C23)[C@H](O)[C@@H]1O C2H4O2 Glycolaldehyde 60.02113 150-13-0 CAS GLN BioCyc GLT BioCyc Dihydrofolate reductase PW001735 PathWhiz GTP cyclohydrolase I 53-57-6 CAS P26281 UniProt Purine Nucleotides De Novo Biosynthesis SubPathway Folate Biosynthesis C00251 KEGG Compound 7,8-dihydroneopterin 3'-triphosphate 7,8-dihydrofolate monoglutamate C00013 KEGG Compound 7,8-dihydroneopterin 3'-phosphate CHEBI:17001 ChEBI O7P2 Pyrophosphate 173.91193 4-amino-4-deoxychorismate synthase dihydropteroate synthase NAD(P) BioCyc dihydroneopterin aldolase 1.0 5957 PubChem-compound Dihydropteroate synthase 562 TAXONOMY Dihydroneopterin aldolase H Hydrogen Ion 1.007825 P0AC13 UniProt CHEBI:15996 ChEBI P0AC16 UniProt C00022 KEGG Compound L-Glutamine 56-65-5 CAS C00020 KEGG Compound C00025 KEGG Compound Dihydrofolate reductase folM Guanosine triphosphate C00266 KEGG Compound HMDB0000243 HMDB Adenosine diphosphate P00903 UniProt C10H15N5O10P2 Adenosine diphosphate 427.02942 1.0 SMP0000925 SMPDB Para-aminobenzoate synthase component 1 CPD-8587 BioCyc C04874 KEGG Compound SMP0000927 SMPDB 4.1.2.25 false 4.1.2.25 7,8-Dihydroneopterin → 6-hydroxymethyl-7,8-dihydropterin + Glycolaldehyde LEFT_TO_RIGHT Reaction3398 false 7,8-dihydroneopterin 3'-phosphate + Water → 7,8-Dihydroneopterin + Phosphate LEFT_TO_RIGHT Water 3.6.1.- false 3.6.1.- 7,8-dihydroneopterin 3'-triphosphate + Water → 7,8-dihydroneopterin 3'-phosphate + Hydrogen Ion + Pyrophosphate LEFT_TO_RIGHT AMP BioCyc 3.5.4.16 false 3.5.4.16 Guanosine triphosphate + Water → 7,8-dihydroneopterin 3'-triphosphate + Formic acid + Hydrogen Ion LEFT_TO_RIGHT HMDB0000250 HMDB SMILES [O-]P([O-])(=O)OP([O-])([O-])=O 7,8-dihydropteroate BioCyc 14000-31-8 CAS HMDB0001341 HMDB 1218-98-0 CAS 756 PubChem-compound C00044 KEGG Compound 7,8-Dihydroneopterin C10H10O6 Chorismate 226.04774 5675 ChemSpider 56-85-9 CAS SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O Dihydrofolate reductase 1.0 CHEBI:17071 ChEBI HMDB0000148 HMDB 18971002 PubChem-compound C14H14N6O3 7,8-Dihydropteroic acid 314.11273 1.0 11542 ChemSpider HMDB0000142 HMDB 7,8-Dihydropteroic acid CHEBI:15422 ChEBI P0AFS3 UniProt Escherichia coli 7732-18-5 CAS 1.0 C00058 KEGG Compound Chorismate 1.0 61-19-8 CAS SMILES NC1=C2N=CN([C@@H]3O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]3O)C2=NC=N1 617-12-9 CAS CH2O2 Formic acid 46.005478 ReactionCatalysis3369 ACTIVATION 127-17-3 CAS Dihydroneopterin aldolase Dihydropteroate synthase 56-86-0 CAS P28305 UniProt ReactionCatalysis3364 ACTIVATION FORMATE BioCyc 10.0 ReactionCatalysis3367 ACTIVATION ReactionCatalysis3368 ACTIVATION ReactionCatalysis3365 ACTIVATION ReactionCatalysis3366 ACTIVATION C5H9NO4 L-Glutamic acid 147.05316 SMILES NC1=NC2=C(N=C(CO)CN2)C(=O)N1 1.0 33032 PubChem-compound SMP0000836 SMPDB SMILES OP(=O)(OCC1=NC2=C(NC1)NC(=N)N=C2[O-])OP([O-])([O-])=O SMILES [H][C@@]1(N)C=CC(=C[C@@]1([H])OC(=C)C([O-])=O)C(O)=O C10H16N5O13P3 Adenosine triphosphate 506.99576 ReactionCatalysis3370 ACTIVATION 1.0 659 PubChem-compound ReactionCatalysis3371 ACTIVATION C00064 KEGG Compound CHEBI:16761 ChEBI P0AFC0 UniProt 8.0 p-Aminobenzoic acid HMDB0000045 HMDB SMILES CC(=O)C(O)=O C7H7NO2 p-Aminobenzoic acid 137.04768 P-AMINO-BENZOATE BioCyc P0A6T5 UniProt 25201779 PubChem-compound ReactionCatalysis3372 ACTIVATION ReactionCatalysis3373 ACTIVATION 962 PubChem-compound CPD-9517 BioCyc 5800 ChemSpider 736 ChemSpider Phosphate P05041 UniProt 1.0 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase C00080 KEGG Compound CHEBI:30753 ChEBI Tetrahydrofolic acid CHEBI:30751 ChEBI 2.0 170 PubChem-compound HMDB0002111 HMDB CHEBI:32816 ChEBI SMILES N[C@@H](CCC(O)=O)C(O)=O PW000816 PathWhiz SMILES OC=O CHEBI:15377 ChEBI C10H10NO5 4-amino-4-deoxychorismate 224.05644 CHEBI:15378 ChEBI SMILES [H+] 14265-44-2 CAS C7H8N5O8P2 (2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl diphosphate 351.9848 C7H9N5O2 6-hydroxymethyl-7,8-dihydropterin 195.07562 PYRUVATE BioCyc 6569 ChemSpider 58-64-0 CAS SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O 5886 PubChem-compound GTP BioCyc SMILES NC1=CC=C(C=C1)C(O)=O 1.0 1.0 CHEBI:57602 ChEBI 165 ChemSpider HMDB0001392 HMDB HMDB0001273 HMDB 644102 PubChem-compound 6083 PubChem-compound SMILES NC1=NC2=C(N=CN2[C@@H]2O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]2O)C(=O)N1 639 ChemSpider 64-18-6 CAS SMILES N[C@@H](CCC(N)=O)C(O)=O C9H13N5O4 7,8-Dihydroneopterin 255.09676 2134-76-1 CAS SubPathwayInteraction1392 SubPathway1392Reaction SubPathwayReaction 22833512 PubChem-compound SubPathwayInteraction1391 SubPathwayReaction SubPathway1391Reaction Aminodeoxychorismate lyase 1.0 1.0 CHEBI:18050 ChEBI Bifunctional protein folC H2O Water 18.010565 CHEBI:17083 ChEBI PW000910 PathWhiz 86-01-1 CAS HMDB0003344 HMDB 1060 PubChem-compound 1061 PubChem-compound SMILES NC1=NC(=O)C2=C(NCC(=N2)C(O)C(O)COP([O-])(=O)OP([O-])(=O)OP([O-])([O-])=O)N1 HMDB0059597 HMDB HMDB0001846 HMDB SMILES [H][C@@](O)(COP(O)([O-])=O)[C@@]([H])(O)C1=NC2=C(NC1)NC(=N)N=C2[O-] 12039 PubChem-compound SMILES [H][C@@](CCC([O-])=O)(NC(=O)C1=CC=C(NCC2=NC3=C(NC2)NC(=N)N=C3[O-])C=C1)C(O)=O SubPathwayInteraction1398 SubPathway1398Reaction SubPathwayReaction PW000908 PathWhiz HMDB0000641 HMDB SMILES OCC=O 13781857 PubChem-compound 1.5.1.3 false 1.5.1.3 7,8-dihydrofolate monoglutamate + Hydrogen Ion + NADPH → NADP + Tetrahydrofolic acid LEFT_TO_RIGHT 6.3.2.17 false 6.3.2.17 7,8-Dihydropteroic acid + Adenosine triphosphate + L-Glutamic acid → 7,8-dihydrofolate monoglutamate + Adenosine diphosphate + Hydrogen Ion + Phosphate LEFT_TO_RIGHT 2.6.1.85 false 2.6.1.85 Chorismate + L-Glutamine → 4-amino-4-deoxychorismate + L-Glutamic acid LEFT_TO_RIGHT 4.1.3.38 false 4.1.3.38 4-amino-4-deoxychorismate → Hydrogen Ion + Pyruvic acid + p-Aminobenzoic acid LEFT_TO_RIGHT 2.5.1.15 false 2.5.1.15 (2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl diphosphate + p-Aminobenzoic acid → 7,8-Dihydropteroic acid + Pyrophosphate LEFT_TO_RIGHT 1.0 2.7.6.3 false 2.7.6.3 6-hydroxymethyl-7,8-dihydropterin + Adenosine triphosphate → (2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl diphosphate + Adenosine monophosphate + Hydrogen Ion LEFT_TO_RIGHT One Carbon Pool by Folate SubPathway folE nudB folB folK folP pabC pabB pabA folM Guanosine triphosphate Water Formic acid Hydrogen Ion 7,8- dihydroneopterin 3'-triphosphate Water Pyrophosphate Hydrogen Ion 7,8- dihydroneopterin 3'-phosphate Water Phosphate 7,8- Dihydroneopterin Glycolaldehyde 6- hydroxymethyl- 7,8- dihydropterin Adenosine triphosphate Adenosine monophosphate Hydrogen Ion (2-amino-4- hydroxy-7,8- dihydropteridin- 6-yl)methyl diphosphate p-Aminobenzoic acid Pyrophosphate 7,8- Dihydropteroic acid 4-amino-4- deoxychorismate