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GTP cyclohydrolase 1 Dihydroneopterin triphosphate pyrophosphatase Dihydroneopterin aldolase 2-amino-4- hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase Dihydropteroate synthase Aminodeoxychorismate lyase Para- aminobenzoate synthase component 1 Para- aminobenzoate synthase glutamine amidotransferase component II Dihydrofolate reductase folM Guanosine triphosphate H 2 O Formic acid H + 7,8- dihydroneopterin 3'-triphosphate H 2 O PP i H + 7,8- dihydroneopterin 3'-phosphate H 2 O P i 7,8- Dihydroneopterin Glycolaldehyde 6- hydroxymethyl- 7,8- dihydropterin ATP AMP H + (2-amino-4- hydroxy-7,8- dihydropteridin- 6-yl)methyl diphosphate p-Aminobenzoic acid PP i 7,8- Dihydropteroic acid 4-amino-4- deoxychorismate Pyruvic acid H + Chorismate L-Glutamine L-Glutamic acid ATP L-Glutamic acid ADP P i H + 7,8- dihydrofolate monoglutamate H + NADPH NADP Tetrahydrofolic acid Magnesium Magnesium Bifunctional protein folC Potassium Magnesium Chorismate Biosynthesis One Carbon Pool by Folate Purine Nucleotides De Novo Biosynthesis Dihydrofolate reductase Magnesium
folE nudB folB folK folP pabC pabB pabA folM Guanosine triphosphate Water Formic acid Hydrogen Ion 7,8- dihydroneopterin 3'-triphosphate Water Pyrophosphate Hydrogen Ion 7,8- dihydroneopterin 3'-phosphate Water Phosphate 7,8- Dihydroneopterin Glycolaldehyde 6- hydroxymethyl- 7,8- dihydropterin Adenosine triphosphate Adenosine monophosphate Hydrogen Ion (2-amino-4- hydroxy-7,8- dihydropteridin- 6-yl)methyl diphosphate p-Aminobenzoic acid Pyrophosphate 7,8- Dihydropteroic acid 4-amino-4- deoxychorismate Pyruvic acid Hydrogen Ion Chorismate L-Glutamine L-Glutamic acid Adenosine triphosphate L-Glutamic acid Adenosine diphosphate Phosphate Hydrogen Ion 7,8- dihydrofolate monoglutamate Hydrogen Ion NADPH NADP Tetrahydrofolic acid folC Chorismate Biosynthesis One Carbon Pool by Folate Purine Nucleotides De Novo Biosynthesis folA