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CHEBI:16015 ChEBI 30572 ChemSpider P0ABQ4 UniProt 6022 PubChem-compound 17215925 ChemSpider SMILES NC1=NC(=O)C2=C(NCC(=N2)C(O)C(O)CO)N1 7057990 PubChem-compound 937 ChemSpider HMDB00250 HMDB P08192 UniProt HMDB01341 HMDB GTP cyclohydrolase 1 Para-aminobenzoate synthase glutamine amidotransferase component II SMILES O Pyrophosphate C10H14N5O7P Adenosine monophosphate 347.06308 1.0 C00568 KEGG Compound CHEBI:20506 ChEBI SMP00836 SMPDB CHEBI:16027 ChEBI HMDB00148 HMDB C9H12N5O7P 7,8-dihydroneopterin 3'-phosphate 333.04742 C9H12N5O13P3 7,8-dihydroneopterin 3'-triphosphate 490.96664 DIHYDROXYPHENYLGLYCOLALDEHYDE BioCyc ATP BioCyc C19H19N7O6 7,8-dihydrofolate monoglutamate 441.14078 5961 PubChem-compound HMDB00142 HMDB 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase 1.0 40480038 PubChem-compound 1.0 1.0 18714427 ChemSpider 1.0 559142 ChemSpider Pyruvic acid ADP BioCyc Dihydroneopterin triphosphate pyrophosphatase C3H4O3 Pyruvic acid 88.016045 (2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl diphosphate 6-hydroxymethyl-7,8-dihydropterin 53-59-8 CAS 5746 ChemSpider 1.0 4-amino-4-deoxychorismate 5742 ChemSpider 1038 PubChem-compound 953 ChemSpider CHEBI:16474 ChEBI Dihydrofolate reductase folM SMILES O[C@@H]1C=CC(=C[C@H]1OC(=C)C(O)=O)C(O)=O 278 ChemSpider C19H23N7O6 Tetrahydrofolic acid 445.171 HMDB59597 HMDB Adenosine monophosphate 25245170 PubChem-compound 1.0 5858 ChemSpider HMDB00243 HMDB O4P Phosphate 94.95342 Para-aminobenzoate synthase component 1 Bifunctional protein folC NADPH 6830 PubChem-compound CHEBI:17333 ChEBI 1010 ChemSpider DIHYDRONEOPTERIN-P3 BioCyc Aminodeoxychorismate lyase C00101 KEGG Compound 1.0 CHEBI:4581 ChEBI NADP PPI BioCyc C21H30N7O17P3 NADPH 745.0911 SMILES NC1=NC2=C(N=C(CNC3=CC=C(C=C3)C(O)=O)CN2)C(=O)N1 C21H29N7O17P3 NADP 744.08325 THF BioCyc 1.0 1.0 NADPH BioCyc C10H16N5O14P3 Guanosine triphosphate 522.99066 Hydrogen Ion C5H10N2O3 L-Glutamine 146.06914 HMDB00217 HMDB Adenosine triphosphate SMILES NC1=NC(=O)C2=C(NC[C@H](CNC3=CC=C(C=C3)C(=O)NC(CCC(O)=O)C(O)=O)N2)N1 CHEBI:58406 ChEBI L-Glutamic acid SMILES [O-]P([O-])([O-])=O 1.0 Formic acid C00009 KEGG Compound HMDB00221 HMDB C00921 KEGG Compound C00008 KEGG Compound C00006 KEGG Compound 1.0 CHEBI:18009 ChEBI PW000773 PathWhiz C00001 KEGG Compound Para-aminobenzoate synthase glutamine amidotransferase component II CHEBI:18361 ChEBI C00005 KEGG Compound CHEBI:18367 ChEBI 141-46-8 CAS 1032 ChemSpider 135-16-0 CAS GTP cyclohydrolase 1 C00002 KEGG Compound 1031 ChemSpider SMILES NC(=O)C1=C[N+](=CC=C1)[C@@H]1O[C@H](CO[P@](O)(=O)O[P@](O)(=O)OC[C@H]2O[C@H]([C@H](OP(O)(O)=O)[C@@H]2O)N2C=NC3=C(N)N=CN=C23)[C@@H](O)[C@H]1O Dihydroneopterin triphosphate pyrophosphatase Glycolaldehyde SMILES NC(=O)C1=CN(C=CC1)[C@H]1O[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]2O[C@@H]([C@@H](OP(O)(O)=O)[C@H]2O)N2C=NC3=C(N)N=CN=C23)[C@H](O)[C@@H]1O C2H4O2 Glycolaldehyde 60.02113 150-13-0 CAS GLN BioCyc HMDB01429 HMDB GLT BioCyc Dihydrofolate reductase GTP cyclohydrolase I 53-57-6 CAS P26281 UniProt SMP00925 SMPDB C00251 KEGG Compound 7,8-dihydroneopterin 3'-triphosphate SMP00927 SMPDB 7,8-dihydrofolate monoglutamate C00013 KEGG Compound 7,8-dihydroneopterin 3'-phosphate CHEBI:17001 ChEBI O7P2 Pyrophosphate 173.91193 4-amino-4-deoxychorismate synthase dihydropteroate synthase NAD(P) BioCyc dihydroneopterin aldolase 1.0 5957 PubChem-compound Dihydropteroate synthase Dihydroneopterin aldolase H Hydrogen Ion 1.007825 P0AC13 UniProt HMDB01412 HMDB CHEBI:15996 ChEBI P0AC16 UniProt C00022 KEGG Compound L-Glutamine 56-65-5 CAS C00020 KEGG Compound C00025 KEGG Compound Dihydrofolate reductase folM Guanosine triphosphate C00266 KEGG Compound Adenosine diphosphate P00903 UniProt C10H15N5O10P2 Adenosine diphosphate 427.02942 1.0 Para-aminobenzoate synthase component 1 CPD-8587 BioCyc HMDB02275 HMDB C04874 KEGG Compound 4.1.2.25 false 4.1.2.25 7,8-Dihydroneopterin → 6-hydroxymethyl-7,8-dihydropterin + Glycolaldehyde LEFT_TO_RIGHT Reaction3398 false 7,8-dihydroneopterin 3'-phosphate + Water → 7,8-Dihydroneopterin + Phosphate LEFT_TO_RIGHT Water 3.6.1.- false 3.6.1.- 7,8-dihydroneopterin 3'-triphosphate + Water → 7,8-dihydroneopterin 3'-phosphate + Hydrogen Ion + Pyrophosphate LEFT_TO_RIGHT AMP BioCyc 3.5.4.16 false 3.5.4.16 Guanosine triphosphate + Water → 7,8-dihydroneopterin 3'-triphosphate + Formic acid + Hydrogen Ion LEFT_TO_RIGHT SMILES [O-]P([O-])(=O)OP([O-])([O-])=O 7,8-dihydropteroate BioCyc 14000-31-8 CAS 1218-98-0 CAS 756 PubChem-compound C00044 KEGG Compound 7,8-Dihydroneopterin C10H10O6 Chorismate 226.04774 5675 ChemSpider 56-85-9 CAS HMDB12199 HMDB SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O Dihydrofolate reductase 1.0 CHEBI:17071 ChEBI 18971002 PubChem-compound HMDB00538 HMDB C14H14N6O3 7,8-Dihydropteroic acid 314.11273 SMP00796 SMPDB 1.0 11542 ChemSpider 7,8-Dihydropteroic acid CHEBI:15422 ChEBI P0AFS3 UniProt 7732-18-5 CAS 1.0 HMDB03344 HMDB C00058 KEGG Compound Chorismate 1.0 61-19-8 CAS SMILES NC1=C2N=CN([C@@H]3O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]3O)C2=NC=N1 617-12-9 CAS CH2O2 Formic acid 46.005478 ReactionCatalysis3369 ACTIVATION 127-17-3 CAS Dihydroneopterin aldolase Dihydropteroate synthase Folate Biosynthesis 56-86-0 CAS P28305 UniProt ReactionCatalysis3364 ACTIVATION FORMATE BioCyc 10.0 ReactionCatalysis3367 ACTIVATION ReactionCatalysis3368 ACTIVATION ReactionCatalysis3365 ACTIVATION ReactionCatalysis3366 ACTIVATION C5H9NO4 L-Glutamic acid 147.05316 SMILES NC1=NC2=C(N=C(CO)CN2)C(=O)N1 1.0 33032 PubChem-compound SMILES OP(=O)(OCC1=NC2=C(NC1)NC(=N)N=C2[O-])OP([O-])([O-])=O SMILES [H][C@@]1(N)C=CC(=C[C@@]1([H])OC(=C)C([O-])=O)C(O)=O HMDB00641 HMDB C10H16N5O13P3 Adenosine triphosphate 506.99576 ReactionCatalysis3370 ACTIVATION 1.0 659 PubChem-compound ReactionCatalysis3371 ACTIVATION C00064 KEGG Compound CHEBI:16761 ChEBI P0AFC0 UniProt 8.0 p-Aminobenzoic acid SMILES CC(=O)C(O)=O C7H7NO2 p-Aminobenzoic acid 137.04768 P-AMINO-BENZOATE BioCyc P0A6T5 UniProt 25201779 PubChem-compound HMDB01846 HMDB ReactionCatalysis3372 ACTIVATION ReactionCatalysis3373 ACTIVATION 962 PubChem-compound CPD-9517 BioCyc 5800 ChemSpider 736 ChemSpider Phosphate P05041 UniProt 1.0 HMDB02111 HMDB 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase C00080 KEGG Compound CHEBI:30753 ChEBI Tetrahydrofolic acid CHEBI:30751 ChEBI 2.0 170 PubChem-compound CHEBI:32816 ChEBI SMILES N[C@@H](CCC(O)=O)C(O)=O PW000816 PathWhiz SMILES OC=O CHEBI:15377 ChEBI C10H10NO5 4-amino-4-deoxychorismate 224.05644 CHEBI:15378 ChEBI SMILES [H+] 14265-44-2 CAS C7H8N5O8P2 (2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl diphosphate 351.9848 C7H9N5O2 6-hydroxymethyl-7,8-dihydropterin 195.07562 PYRUVATE BioCyc 6569 ChemSpider 58-64-0 CAS SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O 5886 PubChem-compound HMDB01392 HMDB HMDB01273 HMDB GTP BioCyc SMILES NC1=CC=C(C=C1)C(O)=O 1.0 1.0 CHEBI:57602 ChEBI 165 ChemSpider 644102 PubChem-compound 6083 PubChem-compound One Carbon Pool by Folate SubPathway Chorismate biosynthesis SubPathway SMILES NC1=NC2=C(N=CN2[C@@H]2O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]2O)C(=O)N1 639 ChemSpider 64-18-6 CAS SMILES N[C@@H](CCC(N)=O)C(O)=O C9H13N5O4 7,8-Dihydroneopterin 255.09676 purine nucleotides de novo biosynthesis SubPathway 2134-76-1 CAS SubPathwayInteraction1392 SubPathway1392Reaction SubPathwayReaction 22833512 PubChem-compound SubPathwayInteraction1391 SubPathwayReaction SubPathway1391Reaction Aminodeoxychorismate lyase 1.0 1.0 CHEBI:18050 ChEBI Bifunctional protein folC H2O Water 18.010565 CHEBI:17083 ChEBI PW000910 PathWhiz 86-01-1 CAS HMDB00045 HMDB 1060 PubChem-compound 1061 PubChem-compound SMILES NC1=NC(=O)C2=C(NCC(=N2)C(O)C(O)COP([O-])(=O)OP([O-])(=O)OP([O-])([O-])=O)N1 SMILES [H][C@@](O)(COP(O)([O-])=O)[C@@]([H])(O)C1=NC2=C(NC1)NC(=N)N=C2[O-] 12039 PubChem-compound SMILES [H][C@@](CCC([O-])=O)(NC(=O)C1=CC=C(NCC2=NC3=C(NC2)NC(=N)N=C3[O-])C=C1)C(O)=O SubPathwayInteraction1398 SubPathway1398Reaction SubPathwayReaction PW000908 PathWhiz SMILES OCC=O 13781857 PubChem-compound 1.5.1.3 false 1.5.1.3 7,8-dihydrofolate monoglutamate + Hydrogen Ion + NADPH → NADP + Tetrahydrofolic acid LEFT_TO_RIGHT 6.3.2.17 false 6.3.2.17 7,8-Dihydropteroic acid + Adenosine triphosphate + L-Glutamic acid → 7,8-dihydrofolate monoglutamate + Adenosine diphosphate + Hydrogen Ion + Phosphate LEFT_TO_RIGHT 2.6.1.85 false 2.6.1.85 Chorismate + L-Glutamine → 4-amino-4-deoxychorismate + L-Glutamic acid LEFT_TO_RIGHT 4.1.3.38 false 4.1.3.38 4-amino-4-deoxychorismate → Hydrogen Ion + Pyruvic acid + p-Aminobenzoic acid LEFT_TO_RIGHT 2.5.1.15 false 2.5.1.15 (2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl diphosphate + p-Aminobenzoic acid → 7,8-Dihydropteroic acid + Pyrophosphate LEFT_TO_RIGHT 1.0 2.7.6.3 false 2.7.6.3 6-hydroxymethyl-7,8-dihydropterin + Adenosine triphosphate → (2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl diphosphate + Adenosine monophosphate + Hydrogen Ion LEFT_TO_RIGHT GTP cyclohydrolase 1 Dihydroneopterin triphosphate pyrophosphatase Dihydroneopterin aldolase 2-amino-4- hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase Dihydropteroate synthase Aminodeoxychorismate lyase Para- aminobenzoate synthase component 1 Para- aminobenzoate synthase glutamine amidotransferase component II Dihydrofolate reductase folM Guanosine triphosphate H 2 O Formic acid H + 7,8- dihydroneopterin 3'-triphosphate H 2 O PP i H + 7,8- dihydroneopterin 3'-phosphate H 2 O P i 7,8- Dihydroneopterin Glycolaldehyde 6- hydroxymethyl- 7,8- dihydropterin ATP AMP H + (2-amino-4- hydroxy-7,8- dihydropteridin- 6-yl)methyl diphosphate p-Aminobenzoic acid PP i 7,8- Dihydropteroic acid 4-amino-4- deoxychorismate Pyruvic acid H + Chorismate L-Glutamine L-Glutamic acid ATP L-Glutamic acid ADP P i H + 7,8- dihydrofolate monoglutamate H + NADPH NADP Tetrahydrofolic acid Magnesium Magnesium Bifunctional protein folC Potassium Magnesium Chorismate biosynthesis One Carbon Pool by Folate purine nucleotides de novo biosynthesis Dihydrofolate reductase Magnesium
CHEBI:16015 ChEBI 30572 ChemSpider P0ABQ4 UniProt 6022 PubChem-compound 17215925 ChemSpider SMILES NC1=NC(=O)C2=C(NCC(=N2)C(O)C(O)CO)N1 7057990 PubChem-compound 937 ChemSpider HMDB00250 HMDB P08192 UniProt HMDB01341 HMDB GTP cyclohydrolase 1 Para-aminobenzoate synthase glutamine amidotransferase component II SMILES O Pyrophosphate C10H14N5O7P Adenosine monophosphate 347.06308 1.0 C00568 KEGG Compound CHEBI:20506 ChEBI http://identifiers.org/smpdb/SMP00836 SMPDB CHEBI:16027 ChEBI HMDB00148 HMDB C9H12N5O7P 7,8-dihydroneopterin 3'-phosphate 333.04742 C9H12N5O13P3 7,8-dihydroneopterin 3'-triphosphate 490.96664 DIHYDROXYPHENYLGLYCOLALDEHYDE BioCyc ATP BioCyc C19H19N7O6 7,8-dihydrofolate monoglutamate 441.14078 5961 PubChem-compound HMDB00142 HMDB 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase 1.0 40480038 PubChem-compound 1.0 1.0 18714427 ChemSpider 1.0 559142 ChemSpider Pyruvic acid ADP BioCyc Dihydroneopterin triphosphate pyrophosphatase C3H4O3 Pyruvic acid 88.016045 (2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl diphosphate 6-hydroxymethyl-7,8-dihydropterin 53-59-8 CAS 5746 ChemSpider 1.0 4-amino-4-deoxychorismate 5742 ChemSpider 1038 PubChem-compound 953 ChemSpider CHEBI:16474 ChEBI Dihydrofolate reductase folM SMILES O[C@@H]1C=CC(=C[C@H]1OC(=C)C(O)=O)C(O)=O 278 ChemSpider C19H23N7O6 Tetrahydrofolic acid 445.171 HMDB59597 HMDB Adenosine monophosphate 25245170 PubChem-compound 1.0 One Carbon Pool by Folate SubPathway 5858 ChemSpider HMDB00243 HMDB O4P Phosphate 94.95342 Para-aminobenzoate synthase component 1 Bifunctional protein folC NADPH 6830 PubChem-compound CHEBI:17333 ChEBI 1010 ChemSpider DIHYDRONEOPTERIN-P3 BioCyc Aminodeoxychorismate lyase C00101 KEGG Compound 1.0 CHEBI:4581 ChEBI NADP PPI BioCyc C21H30N7O17P3 NADPH 745.0911 SMILES NC1=NC2=C(N=C(CNC3=CC=C(C=C3)C(O)=O)CN2)C(=O)N1 C21H29N7O17P3 NADP 744.08325 THF BioCyc 1.0 1.0 NADPH BioCyc C10H16N5O14P3 Guanosine triphosphate 522.99066 Hydrogen Ion C5H10N2O3 L-Glutamine 146.06914 HMDB00217 HMDB Adenosine triphosphate SMILES NC1=NC(=O)C2=C(NC[C@H](CNC3=CC=C(C=C3)C(=O)NC(CCC(O)=O)C(O)=O)N2)N1 CHEBI:58406 ChEBI L-Glutamic acid SMILES [O-]P([O-])([O-])=O 1.0 Formic acid C00009 KEGG Compound HMDB00221 HMDB C00921 KEGG Compound C00008 KEGG Compound C00006 KEGG Compound 1.0 CHEBI:18009 ChEBI PW000773 PathWhiz C00001 KEGG Compound Para-aminobenzoate synthase glutamine amidotransferase component II CHEBI:18361 ChEBI C00005 KEGG Compound CHEBI:18367 ChEBI 141-46-8 CAS 1032 ChemSpider 135-16-0 CAS GTP cyclohydrolase 1 C00002 KEGG Compound 1031 ChemSpider SMILES NC(=O)C1=C[N+](=CC=C1)[C@@H]1O[C@H](CO[P@](O)(=O)O[P@](O)(=O)OC[C@H]2O[C@H]([C@H](OP(O)(O)=O)[C@@H]2O)N2C=NC3=C(N)N=CN=C23)[C@@H](O)[C@H]1O Dihydroneopterin triphosphate pyrophosphatase Glycolaldehyde SMILES NC(=O)C1=CN(C=CC1)[C@H]1O[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]2O[C@@H]([C@@H](OP(O)(O)=O)[C@H]2O)N2C=NC3=C(N)N=CN=C23)[C@H](O)[C@@H]1O C2H4O2 Glycolaldehyde 60.02113 150-13-0 CAS GLN BioCyc HMDB01429 HMDB GLT BioCyc Dihydrofolate reductase GTP cyclohydrolase I 53-57-6 CAS P26281 UniProt http://identifiers.org/smpdb/SMP00925 SMPDB C00251 KEGG Compound 7,8-dihydroneopterin 3'-triphosphate http://identifiers.org/smpdb/SMP00927 SMPDB 7,8-dihydrofolate monoglutamate C00013 KEGG Compound 7,8-dihydroneopterin 3'-phosphate CHEBI:17001 ChEBI O7P2 Pyrophosphate 173.91193 4-amino-4-deoxychorismate synthase dihydropteroate synthase NAD(P) BioCyc dihydroneopterin aldolase 1.0 5957 PubChem-compound Dihydropteroate synthase Dihydroneopterin aldolase H Hydrogen Ion 1.007825 P0AC13 UniProt HMDB01412 HMDB CHEBI:15996 ChEBI P0AC16 UniProt C00022 KEGG Compound L-Glutamine 56-65-5 CAS C00020 KEGG Compound C00025 KEGG Compound Dihydrofolate reductase folM Guanosine triphosphate C00266 KEGG Compound Adenosine diphosphate P00903 UniProt C10H15N5O10P2 Adenosine diphosphate 427.02942 1.0 purine nucleotides de novo biosynthesis SubPathway Para-aminobenzoate synthase component 1 CPD-8587 BioCyc HMDB02275 HMDB C04874 KEGG Compound 4.1.2.25 false 4.1.2.25 7,8-Dihydroneopterin → 6-hydroxymethyl-7,8-dihydropterin + Glycolaldehyde LEFT_TO_RIGHT Reaction3398 false 7,8-dihydroneopterin 3'-phosphate + Water → 7,8-Dihydroneopterin + Phosphate LEFT_TO_RIGHT Water 3.6.1.- false 3.6.1.- 7,8-dihydroneopterin 3'-triphosphate + Water → 7,8-dihydroneopterin 3'-phosphate + Hydrogen Ion + Pyrophosphate LEFT_TO_RIGHT AMP BioCyc 3.5.4.16 false 3.5.4.16 Guanosine triphosphate + Water → 7,8-dihydroneopterin 3'-triphosphate + Formic acid + Hydrogen Ion LEFT_TO_RIGHT SMILES [O-]P([O-])(=O)OP([O-])([O-])=O 7,8-dihydropteroate BioCyc 14000-31-8 CAS 1218-98-0 CAS 756 PubChem-compound C00044 KEGG Compound 7,8-Dihydroneopterin C10H10O6 Chorismate 226.04774 5675 ChemSpider 56-85-9 CAS HMDB12199 HMDB SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O Dihydrofolate reductase 1.0 CHEBI:17071 ChEBI 18971002 PubChem-compound HMDB00538 HMDB C14H14N6O3 7,8-Dihydropteroic acid 314.11273 http://identifiers.org/smpdb/SMP00796 SMPDB 1.0 11542 ChemSpider 7,8-Dihydropteroic acid CHEBI:15422 ChEBI P0AFS3 UniProt Chorismate biosynthesis SubPathway 7732-18-5 CAS 1.0 HMDB03344 HMDB C00058 KEGG Compound Chorismate 1.0 61-19-8 CAS SMILES NC1=C2N=CN([C@@H]3O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]3O)C2=NC=N1 617-12-9 CAS CH2O2 Formic acid 46.005478 ReactionCatalysis3369 ACTIVATION 127-17-3 CAS Dihydroneopterin aldolase Dihydropteroate synthase Folate Biosynthesis 56-86-0 CAS P28305 UniProt ReactionCatalysis3364 ACTIVATION FORMATE BioCyc 10.0 ReactionCatalysis3367 ACTIVATION ReactionCatalysis3368 ACTIVATION ReactionCatalysis3365 ACTIVATION ReactionCatalysis3366 ACTIVATION C5H9NO4 L-Glutamic acid 147.05316 SMILES NC1=NC2=C(N=C(CO)CN2)C(=O)N1 1.0 33032 PubChem-compound SMILES OP(=O)(OCC1=NC2=C(NC1)NC(=N)N=C2[O-])OP([O-])([O-])=O SMILES [H][C@@]1(N)C=CC(=C[C@@]1([H])OC(=C)C([O-])=O)C(O)=O HMDB00641 HMDB C10H16N5O13P3 Adenosine triphosphate 506.99576 ReactionCatalysis3370 ACTIVATION 1.0 659 PubChem-compound ReactionCatalysis3371 ACTIVATION C00064 KEGG Compound CHEBI:16761 ChEBI P0AFC0 UniProt 8.0 p-Aminobenzoic acid SMILES CC(=O)C(O)=O C7H7NO2 p-Aminobenzoic acid 137.04768 P-AMINO-BENZOATE BioCyc P0A6T5 UniProt 25201779 PubChem-compound HMDB01846 HMDB ReactionCatalysis3372 ACTIVATION ReactionCatalysis3373 ACTIVATION 962 PubChem-compound CPD-9517 BioCyc 5800 ChemSpider 736 ChemSpider Phosphate P05041 UniProt 1.0 HMDB02111 HMDB 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase C00080 KEGG Compound CHEBI:30753 ChEBI Tetrahydrofolic acid CHEBI:30751 ChEBI 2.0 170 PubChem-compound CHEBI:32816 ChEBI SMILES N[C@@H](CCC(O)=O)C(O)=O PW000816 PathWhiz SMILES OC=O CHEBI:15377 ChEBI C10H10NO5 4-amino-4-deoxychorismate 224.05644 CHEBI:15378 ChEBI SMILES [H+] 14265-44-2 CAS C7H8N5O8P2 (2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl diphosphate 351.9848 C7H9N5O2 6-hydroxymethyl-7,8-dihydropterin 195.07562 PYRUVATE BioCyc 6569 ChemSpider 58-64-0 CAS SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O 5886 PubChem-compound HMDB01392 HMDB HMDB01273 HMDB GTP BioCyc SMILES NC1=CC=C(C=C1)C(O)=O 1.0 1.0 CHEBI:57602 ChEBI 165 ChemSpider 644102 PubChem-compound 6083 PubChem-compound SMILES NC1=NC2=C(N=CN2[C@@H]2O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]2O)C(=O)N1 639 ChemSpider 64-18-6 CAS SMILES N[C@@H](CCC(N)=O)C(O)=O C9H13N5O4 7,8-Dihydroneopterin 255.09676 2134-76-1 CAS SubPathwayInteraction1392 SubPathway1392Reaction SubPathwayReaction 22833512 PubChem-compound SubPathwayInteraction1391 SubPathwayReaction SubPathway1391Reaction Aminodeoxychorismate lyase 1.0 1.0 CHEBI:18050 ChEBI Bifunctional protein folC H2O Water 18.010565 CHEBI:17083 ChEBI PW000910 PathWhiz 86-01-1 CAS HMDB00045 HMDB 1060 PubChem-compound 1061 PubChem-compound SMILES NC1=NC(=O)C2=C(NCC(=N2)C(O)C(O)COP([O-])(=O)OP([O-])(=O)OP([O-])([O-])=O)N1 SMILES [H][C@@](O)(COP(O)([O-])=O)[C@@]([H])(O)C1=NC2=C(NC1)NC(=N)N=C2[O-] 12039 PubChem-compound SMILES [H][C@@](CCC([O-])=O)(NC(=O)C1=CC=C(NCC2=NC3=C(NC2)NC(=N)N=C3[O-])C=C1)C(O)=O SubPathwayInteraction1398 SubPathway1398Reaction SubPathwayReaction PW000908 PathWhiz SMILES OCC=O 13781857 PubChem-compound 1.5.1.3 false 1.5.1.3 7,8-dihydrofolate monoglutamate + Hydrogen Ion + NADPH → NADP + Tetrahydrofolic acid LEFT_TO_RIGHT 6.3.2.17 false 6.3.2.17 7,8-Dihydropteroic acid + Adenosine triphosphate + L-Glutamic acid → 7,8-dihydrofolate monoglutamate + Adenosine diphosphate + Hydrogen Ion + Phosphate LEFT_TO_RIGHT 2.6.1.85 false 2.6.1.85 Chorismate + L-Glutamine → 4-amino-4-deoxychorismate + L-Glutamic acid LEFT_TO_RIGHT 4.1.3.38 false 4.1.3.38 4-amino-4-deoxychorismate → Hydrogen Ion + Pyruvic acid + p-Aminobenzoic acid LEFT_TO_RIGHT 2.5.1.15 false 2.5.1.15 (2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl diphosphate + p-Aminobenzoic acid → 7,8-Dihydropteroic acid + Pyrophosphate LEFT_TO_RIGHT 1.0 2.7.6.3 false 2.7.6.3 6-hydroxymethyl-7,8-dihydropterin + Adenosine triphosphate → (2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl diphosphate + Adenosine monophosphate + Hydrogen Ion LEFT_TO_RIGHT