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Pathway Description
Intracellular Signalling Through FSH Receptor and Follicle Stimulating Hormone
Homo sapiens
Protein Pathway
Created: 2013-08-22
Last Updated: 2019-09-12
The follicle-stimulating hormone receptor (FSHR) is a transmembrane G protein-coupled receptor located in the ovary, testis, and uterus. As its name suggests, the receptor is activated by follicle-stimulating hormone (FSH) and plays an important role in the regulation of reproduction. In the ovaries, FSHRs present on granulosa cells initiate follicular development. In the testis, FSHRs present on Sertoli cells are essential for spermatogenesis. The FSH receptor activates G(s) proteins which leads to the activation of adenylyl cyclase and produces the secondary messenger cAMP. cAMP then activates protein kinase A (PKA) which phosphorylates downstream effectors that lead to a specific cellular response.
References
Intracellular Signalling Through FSH Receptor and Follicle Stimulating Hormone References
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Pubmed: 9408742
Krauss, G. Biochemistry of signal transduction and regulation. (3rd ed.) (2003) Weinheim; New York : Wiley-VCH
Asatiani K, Gromoll J, Eckardstein SV, Zitzmann M, Nieschlag E, Simoni M: Distribution and function of FSH receptor genetic variants in normal men. Andrologia. 2002 Jun;34(3):172-6.
Pubmed: 12059813
Minegishi T, Nakamura K, Takakura Y, Ibuki Y, Igarashi M, Minegish T [corrected to Minegishi T]: Cloning and sequencing of human FSH receptor cDNA. Biochem Biophys Res Commun. 1991 Mar 29;175(3):1125-30. doi: 10.1016/0006-291x(91)91682-3.
Pubmed: 1709010
Tilly JL, Aihara T, Nishimori K, Jia XC, Billig H, Kowalski KI, Perlas EA, Hsueh AJ: Expression of recombinant human follicle-stimulating hormone receptor: species-specific ligand binding, signal transduction, and identification of multiple ovarian messenger ribonucleic acid transcripts. Endocrinology. 1992 Aug;131(2):799-806. doi: 10.1210/endo.131.2.1322283.
Pubmed: 1322283
Kelton CA, Cheng SV, Nugent NP, Schweickhardt RL, Rosenthal JL, Overton SA, Wands GD, Kuzeja JB, Luchette CA, Chappel SC: The cloning of the human follicle stimulating hormone receptor and its expression in COS-7, CHO, and Y-1 cells. Mol Cell Endocrinol. 1992 Nov;89(1-2):141-51. doi: 10.1016/0303-7207(92)90220-z.
Pubmed: 1301382
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Pubmed: 3093273
Harris BA: Complete cDNA sequence of a human stimulatory GTP-binding protein alpha subunit. Nucleic Acids Res. 1988 Apr 25;16(8):3585. doi: 10.1093/nar/16.8.3585.
Pubmed: 3131741
Kozasa T, Itoh H, Tsukamoto T, Kaziro Y: Isolation and characterization of the human Gs alpha gene. Proc Natl Acad Sci U S A. 1988 Apr;85(7):2081-5. doi: 10.1073/pnas.85.7.2081.
Pubmed: 3127824
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Pubmed: 27108799
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Pubmed: 3095147
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Pubmed: 16710414
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Pubmed: 11714923
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