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Transport1212 false Thyroxine (→) Transport: Homo sapiens, Cell, Endocytic Vesicle to Homo sapiens, Cell, Cytosol LEFT_TO_RIGHT Transport1214 false Thyroxine (→) Transport: Homo sapiens, Cell, Cytosol to Homo sapiens, Cell, Exocytic Vesicle LEFT_TO_RIGHT 7722-84-1 CAS 28015 ChemSpider 923 PubChem-compound 937 ChemSpider GO:0030139 GENE ONTOLOGY Transport1216 false Liothyronine (→) Transport: Homo sapiens, Cell, Exocytic Vesicle to Homo sapiens, Cell, Extracellular Space LEFT_TO_RIGHT 20461-54-5 CAS Transport1215 false Thyroxine (→) Transport: Homo sapiens, Cell, Exocytic Vesicle to Homo sapiens, Cell, Extracellular Space LEFT_TO_RIGHT 25201348 PubChem-compound P04839 UniProt 1.0 HMDB0003125 HMDB SMILES OO SMILES O GO:0070382 GENE ONTOLOGY Thyroid peroxidase L-THYROXINE BioCyc 1.0 Thyroid Hormone Synthesis SMILES [Na+] NADPH oxidase 4 CHEBI:16382 ChEBI Transport249 false Iodide (→) Transport: Homo sapiens, Cell, Cytosol to Homo sapiens, Extracellular Space LEFT_TO_RIGHT Thyroid peroxidase Transport248 false Sodium (→), Iodide (→) Transport: Homo sapiens, Blood Vessel to Homo sapiens, Cell, Cytosol LEFT_TO_RIGHT 1.0 Transport255 false [thyroglobulin]-thyroxine (→) Transport: Homo sapiens, Extracellular Space to Homo sapiens, Cell, Cytosol LEFT_TO_RIGHT Transport254 false [thyroglobulin]-3,5,3'-triiodo-L-thyronine (→) Transport: Homo sapiens, Extracellular Space to Homo sapiens, Cell, Cytosol LEFT_TO_RIGHT Endocytic Vesicle P07202 UniProt 1.0 GO:0005829 GENE ONTOLOGY TransportCatalysis215 ACTIVATION NADPH oxidase 4 TransportCatalysis214 ACTIVATION 1.0 Cytochrome b-245 heavy chain 5614 ChemSpider 30165 PubChem-compound CHEBI:16240 ChEBI Liothyronine 1.0 Iodide Q9HBY0 UniProt Transport1539 false Liothyronine (→) Transport: Homo sapiens, Cell, Endocytic Vesicle to Homo sapiens, Cell, Cytosol LEFT_TO_RIGHT Cytosol Thyroxine 1.0 1.0 Sodium/iodide cotransporter Liothyronine C00001 KEGG Compound C01330 KEGG Compound 5920 PubChem-compound 1.11.1.8 false 1.11.1.8 Hydrogen peroxide + Iodide + [thyroglobulin]-3-iodo-L-tyrosine → 2 Water + [thyroglobulin]-3,5-diiodo-L-tyrosine LEFT_TO_RIGHT HMDB0000588 HMDB 1.0 GO:0005634 GENE ONTOLOGY Iodide Dual oxidase 2 Reaction2258 false [thyroglobulin]-3,5,3'-triiodo-L-thyronine → Liothyronine + Thyroglobulin LEFT_TO_RIGHT Reaction2259 false [thyroglobulin]-thyroxine → Thyroglobulin + Thyroxine LEFT_TO_RIGHT 1.11.1.8 false 1.11.1.8 Hydrogen peroxide + 2 [thyroglobulin]-3,5-diiodo-L-tyrosine → 2 Water + [thyroglobulin]-3,5,3'-triiodo-L-thyronine + [thyroglobulin]-aminoacrylate LEFT_TO_RIGHT 1.11.1.8 false 1.11.1.8 Hydrogen peroxide + Iodide + [thyroglobulin]-3,5,3'-triiodo-L-thyronine → 2 Water + [thyroglobulin]-thyroxine LEFT_TO_RIGHT Transport1552 false Thyroglobulin with L-Tyrosine (↔) Transport: Homo sapiens, Cell, Endocytic Vesicle to Homo sapiens, Cell, Cytosol LEFT_TO_RIGHT ReactionCatalysis2190 ACTIVATION Q9NRD8 UniProt LIOTHYRONINE BioCyc Q9NRD9 UniProt 1.0 C15H11I4NO4 Thyroxine 776.6867 Transport1550 false Thyroglobulin with L-Tyrosine (←) Transport: Homo sapiens, Cell, Cytosol to Homo sapiens, Cell, Exocytic Vesicle LEFT_TO_RIGHT SubPathwayInteraction816 SubPathwayReaction SubPathway816Reaction Extracellular Space CHEBI:18332 ChEBI 2.0 SMILES [I-] 1.0 Transport1544 false Thyroglobulin with L-Tyrosine (←) Transport: Homo sapiens, Cell, Endocytic Vesicle to Homo sapiens, Cell, Cytosol LEFT_TO_RIGHT Cytochrome b-245 light chain Dual oxidase 2 Transport1540 false Liothyronine (→) Transport: Homo sapiens, Cell, Cytosol to Homo sapiens, Cell, Exocytic Vesicle LEFT_TO_RIGHT NADPH oxidase 3 Transport1549 false Thyroglobulin with L-Tyrosine (←) Transport: Homo sapiens, Cell, Exocytic Vesicle to Homo sapiens, Cell, Nucleus LEFT_TO_RIGHT Pendrin C00027 KEGG Compound 1.0 C15H12I3NO4 Liothyronine 650.79004 GO:0005615 GENE ONTOLOGY HMDB0000248 HMDB C00708 KEGG Compound CHEBI:29101 ChEBI Thyroglobulin Cytochrome b-245 heavy chain HMDB0012238 HMDB Thyroid peroxidase 899 ChemSpider Sodium 1.0 Thyroglobulin SubPathwayOutput HYDROGEN-PEROXIDE BioCyc 1.0 1.0 PW000693 PathWhiz CPD-387 BioCyc Sodium/iodide cotransporter Thyroglobulin Cytochrome b-245 light chain Dual oxidase 1 C02465 KEGG Compound HMDB0000265 HMDB 763 ChemSpider 1.0 1.11.1.8 false 1.11.1.8 Hydrogen peroxide + Iodide + Thyroglobulin with L-Tyrosine → Water + [thyroglobulin]-3-iodo-L-tyrosine LEFT_TO_RIGHT 2.0 SMILES N[C@@H](CC1=CC(I)=C(OC2=CC(I)=C(O)C=C2)C(I)=C1)C(O)=O 17341-25-2 CAS 784 PubChem-compound CHEBI:18258 ChEBI Thyroglobulin secretion SubPathway Homo sapiens 1.0 7732-18-5 CAS 1.0 6893-02-3 CAS Exocytic Vesicle 1.0 2.0 Liothyronine C01829 KEGG Compound Water SMP0000716 SMPDB 1.0 F5H104 UniProt SMILES N[C@@H](CC1=CC(I)=C(OC2=CC(I)=C(O)C(I)=C2)C(I)=C1)C(O)=O 1.0 9606 TAXONOMY 962 PubChem-compound 1.0 Thyroglobulin Pendrin Sodium Hydrogen peroxide 1.0 Thyroxine I Iodide 126.904465 Dual oxidase 1 1.0 HMDB0002111 HMDB CHEBI:15377 ChEBI Q92911 UniProt 1.0 P01266 UniProt Liothyronine Thyroglobulin Thyroxine Q9NPH5 UniProt 51-48-9 CAS H2O2 Hydrogen peroxide 34.005478 H2O Water 18.010565 Iodide NADPH oxidase 3 5707 ChemSpider 1.0 Thyroxine Nucleus Thyroglobulin Na Sodium 22.989769 P13498 UniProt ReactionCatalysis2121 ACTIVATION ReactionCatalysis2120 ACTIVATION ReactionCatalysis2122 ACTIVATION Thyroglobulin Sodium/iodide cotransporter Pendrin Thyroglobulin Thyroglobulin Thyroglobulin Thyroglobulin Thyroglobulin Thyroglobulin Thyroglobulin Thyroglobulin Thyroglobulin Thyroglobulin Thyroglobulin Thyroid peroxidase Thyroglobulin Thyroid peroxidase Thyroid peroxidase Thyroglobulin Thyroglobulin Thyroid peroxidase Na + Na + Iodide Iodide Iodide Thyroxine Thyroxine Thyroxine Thyroxine Liothyronine Liothyronine Liothyronine Liothyronine Iodide H 2 O 2 H 2 O H 2 O 2 H 2 O Iodide H 2 O 2 H 2 O H 2 O 2 H 2 O L-Tyrosine Liothyronine Liothyronine Thyroxine Thyroxine L-Tyrosine L-Tyrosine L-Tyrosine L-Tyrosine L-Tyrosine Iodotyrosine 3,5-Diiodo-L- tyrosine Calcium FAD Heme 2-Aminoacrylic acid Calcium FAD Heme Calcium FAD Heme Calcium FAD Heme Thyroglobulin secretion Endocytosis Exocytosis Proteolysis Proteolysis Endocytosis Exocytosis Blood Blood Vessel Intracellular Space Thyroid follicular cell Endothelium Follicle Colloid
Transport1212 false Thyroxine (→) Transport: Homo sapiens, Cell, Endocytic Vesicle to Homo sapiens, Cell, Cytosol LEFT_TO_RIGHT Transport1214 false Thyroxine (→) Transport: Homo sapiens, Cell, Cytosol to Homo sapiens, Cell, Exocytic Vesicle LEFT_TO_RIGHT 7722-84-1 CAS 28015 ChemSpider 923 PubChem-compound 937 ChemSpider GO:0030139 GENE ONTOLOGY Transport1216 false Liothyronine (→) Transport: Homo sapiens, Cell, Exocytic Vesicle to Homo sapiens, Cell, Extracellular Space LEFT_TO_RIGHT 20461-54-5 CAS Transport1215 false Thyroxine (→) Transport: Homo sapiens, Cell, Exocytic Vesicle to Homo sapiens, Cell, Extracellular Space LEFT_TO_RIGHT 25201348 PubChem-compound P04839 UniProt 1.0 HMDB0003125 HMDB SMILES OO SMILES O GO:0070382 GENE ONTOLOGY Thyroid peroxidase L-THYROXINE BioCyc 1.0 Thyroid Hormone Synthesis SMILES [Na+] NADPH oxidase 4 CHEBI:16382 ChEBI Transport249 false Iodide (→) Transport: Homo sapiens, Cell, Cytosol to Homo sapiens, Extracellular Space LEFT_TO_RIGHT Thyroid peroxidase Transport248 false Sodium (→), Iodide (→) Transport: Homo sapiens, Blood Vessel to Homo sapiens, Cell, Cytosol LEFT_TO_RIGHT 1.0 Transport255 false [thyroglobulin]-thyroxine (→) Transport: Homo sapiens, Extracellular Space to Homo sapiens, Cell, Cytosol LEFT_TO_RIGHT Transport254 false [thyroglobulin]-3,5,3'-triiodo-L-thyronine (→) Transport: Homo sapiens, Extracellular Space to Homo sapiens, Cell, Cytosol LEFT_TO_RIGHT Endocytic Vesicle P07202 UniProt 1.0 GO:0005829 GENE ONTOLOGY TransportCatalysis215 ACTIVATION NADPH oxidase 4 TransportCatalysis214 ACTIVATION 1.0 Cytochrome b-245 heavy chain 5614 ChemSpider 30165 PubChem-compound CHEBI:16240 ChEBI Liothyronine 1.0 Iodide Q9HBY0 UniProt Transport1539 false Liothyronine (→) Transport: Homo sapiens, Cell, Endocytic Vesicle to Homo sapiens, Cell, Cytosol LEFT_TO_RIGHT Cytosol Thyroxine 1.0 1.0 Sodium/iodide cotransporter Liothyronine C00001 KEGG Compound C01330 KEGG Compound 5920 PubChem-compound 1.11.1.8 false 1.11.1.8 Hydrogen peroxide + Iodide + [thyroglobulin]-3-iodo-L-tyrosine → 2 Water + [thyroglobulin]-3,5-diiodo-L-tyrosine LEFT_TO_RIGHT HMDB0000588 HMDB 1.0 GO:0005634 GENE ONTOLOGY Iodide Dual oxidase 2 Reaction2258 false [thyroglobulin]-3,5,3'-triiodo-L-thyronine → Liothyronine + Thyroglobulin LEFT_TO_RIGHT Reaction2259 false [thyroglobulin]-thyroxine → Thyroglobulin + Thyroxine LEFT_TO_RIGHT 1.11.1.8 false 1.11.1.8 Hydrogen peroxide + 2 [thyroglobulin]-3,5-diiodo-L-tyrosine → 2 Water + [thyroglobulin]-3,5,3'-triiodo-L-thyronine + [thyroglobulin]-aminoacrylate LEFT_TO_RIGHT 1.11.1.8 false 1.11.1.8 Hydrogen peroxide + Iodide + [thyroglobulin]-3,5,3'-triiodo-L-thyronine → 2 Water + [thyroglobulin]-thyroxine LEFT_TO_RIGHT Transport1552 false Thyroglobulin with L-Tyrosine (↔) Transport: Homo sapiens, Cell, Endocytic Vesicle to Homo sapiens, Cell, Cytosol LEFT_TO_RIGHT ReactionCatalysis2190 ACTIVATION Q9NRD8 UniProt LIOTHYRONINE BioCyc Q9NRD9 UniProt 1.0 C15H11I4NO4 Thyroxine 776.6867 Transport1550 false Thyroglobulin with L-Tyrosine (←) Transport: Homo sapiens, Cell, Cytosol to Homo sapiens, Cell, Exocytic Vesicle LEFT_TO_RIGHT SubPathwayInteraction816 SubPathwayReaction SubPathway816Reaction Extracellular Space CHEBI:18332 ChEBI 2.0 SMILES [I-] 1.0 Transport1544 false Thyroglobulin with L-Tyrosine (←) Transport: Homo sapiens, Cell, Endocytic Vesicle to Homo sapiens, Cell, Cytosol LEFT_TO_RIGHT Cytochrome b-245 light chain Dual oxidase 2 Transport1540 false Liothyronine (→) Transport: Homo sapiens, Cell, Cytosol to Homo sapiens, Cell, Exocytic Vesicle LEFT_TO_RIGHT NADPH oxidase 3 Transport1549 false Thyroglobulin with L-Tyrosine (←) Transport: Homo sapiens, Cell, Exocytic Vesicle to Homo sapiens, Cell, Nucleus LEFT_TO_RIGHT Pendrin C00027 KEGG Compound 1.0 C15H12I3NO4 Liothyronine 650.79004 GO:0005615 GENE ONTOLOGY HMDB0000248 HMDB C00708 KEGG Compound CHEBI:29101 ChEBI Thyroglobulin Cytochrome b-245 heavy chain HMDB0012238 HMDB Thyroid peroxidase 899 ChemSpider Sodium 1.0 Thyroglobulin SubPathwayOutput HYDROGEN-PEROXIDE BioCyc 1.0 1.0 PW000693 PathWhiz CPD-387 BioCyc Sodium/iodide cotransporter Thyroglobulin Cytochrome b-245 light chain Dual oxidase 1 C02465 KEGG Compound HMDB0000265 HMDB 763 ChemSpider 1.0 1.11.1.8 false 1.11.1.8 Hydrogen peroxide + Iodide + Thyroglobulin with L-Tyrosine → Water + [thyroglobulin]-3-iodo-L-tyrosine LEFT_TO_RIGHT 2.0 SMILES N[C@@H](CC1=CC(I)=C(OC2=CC(I)=C(O)C=C2)C(I)=C1)C(O)=O 17341-25-2 CAS 784 PubChem-compound CHEBI:18258 ChEBI Thyroglobulin secretion SubPathway Homo sapiens 1.0 7732-18-5 CAS 1.0 6893-02-3 CAS Exocytic Vesicle 1.0 2.0 Liothyronine C01829 KEGG Compound Water SMP0000716 SMPDB 1.0 F5H104 UniProt SMILES N[C@@H](CC1=CC(I)=C(OC2=CC(I)=C(O)C(I)=C2)C(I)=C1)C(O)=O 1.0 9606 TAXONOMY 962 PubChem-compound 1.0 Thyroglobulin Pendrin Sodium Hydrogen peroxide 1.0 Thyroxine I Iodide 126.904465 Dual oxidase 1 1.0 HMDB0002111 HMDB CHEBI:15377 ChEBI Q92911 UniProt 1.0 P01266 UniProt Liothyronine Thyroglobulin Thyroxine Q9NPH5 UniProt 51-48-9 CAS H2O2 Hydrogen peroxide 34.005478 H2O Water 18.010565 Iodide NADPH oxidase 3 5707 ChemSpider 1.0 Thyroxine Nucleus Thyroglobulin Na Sodium 22.989769 P13498 UniProt ReactionCatalysis2121 ACTIVATION ReactionCatalysis2120 ACTIVATION ReactionCatalysis2122 ACTIVATION TG SLC5A5 SLC26A4 TG TG TG TG TG TG TG TG TG TG TG TPO CYBB NOX3 CYBA DUOX1 DUOX2 NOX4 TG TPO CYBB NOX3 CYBA DUOX1 DUOX2 NOX4 TPO CYBB NOX3 CYBA DUOX1 DUOX2 NOX4 TG TG TPO CYBB NOX3 CYBA DUOX1 DUOX2 NOX4 Sodium Sodium Iodide Iodide Iodide Thyroxine Thyroxine Thyroxine Thyroxine Liothyronine Liothyronine Liothyronine Liothyronine Iodide Hydrogen peroxide Water Hydrogen peroxide Water Iodide Hydrogen peroxide Water Hydrogen peroxide Water Thyroglobulin secretion