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P0CG48 UniProt Tyrosine-protein kinase Lck 937 ChemSpider T cell receptor alpha constant Protein kinase C alpha type Proto-oncogene vav P63000 UniProt Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform Nuclear factor of activated T-cells, cytoplasmic 4 direct_interaction Nuclear factor of activated T-cells, cytoplasmic 3 P43403 UniProt Dual specificity mitogen-activated protein kinase kinase 1 SMILES O T cell receptor (Homo sapiens)_T-cell surface glycoprotein CD3 (Homo sapiens) Mitogen-activated protein kinase 8 1.0 Antigen P04049 UniProt Mitogen-activated protein kinase kinase kinase 1 P19419 UniProt SMILES CCCCCCCCCCCCCCCCCC(=O)OCC(COP([O-])(=O)O[C@@H]1[C@H](O)[C@H](O)[C@@H](OP([O-])([O-])=O)[C@H](OP([O-])([O-])=O)[C@H]1O)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC Water Q14934 UniProt T cell receptor beta constant 1 P29353 UniProt Protein kinase C alpha type 1.0 P35236 UniProt Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform P01100 UniProt 1.0 Tyrosine-protein kinase ZAP-70 HMDB0015002 HMDB CHEBI:16595 ChEBI T cell receptor Calmodulin-1 T-cell surface glycoprotein CD3 85166-31-0 CAS Calmodulin-2 T cell receptor beta constant 1 P06239 UniProt Calmodulin-3 Q12968 UniProt 1.0 T-cell surface glycoprotein CD3 epsilon chain T-cell surface glycoprotein CD3 delta chain T-cell surface glycoprotein CD3 gamma chain SMILES CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O)C(C)C SMILES CCCCCCCCCCCCCCCC(=O)OCC(CO)OC(=O)CCCCCCC\C=C\CCCCCCCC Nuclear factor of activated T-cells Antigen P01112 UniProt O4P Phosphate 94.95342 P06241 UniProt Interaction801 Linker for activation of T-cells family member 1 with Phosphate activates Growth factor receptor-bound protein 2 Interaction800 Linker for activation of T-cells family member 1 with Phosphate activates SHC-transforming protein 1 Interaction803 Son of sevenless homolog 1 activates RAS guanyl-releasing protein 1 Q04206 UniProt Interaction802 Linker for activation of T-cells family member 1 with Phosphate activates Son of sevenless homolog 1 Interaction805 GTPase HRas activates RAF proto-oncogene serine/threonine-protein kinase without zinc Interaction804 RAS guanyl-releasing protein 1 activates GTPase HRas Interaction807 Active Dual specificity mitogen-activated protein kinase kinase 1 activates Mitogen-activated protein kinase 3 with Phosphate Interaction806 RAF proto-oncogene serine/threonine-protein kinase without zinc activates Active Dual specificity mitogen-activated protein kinase kinase 1 Interaction809 GTPase HRas activates phosphoinositide (PIK) Complex 266 ChemSpider Interaction808 Tyrosine-protein phosphatase non-receptor type 7 inhibits Mitogen-activated protein kinase 3 with Phosphate Proto-oncogene c-Fos Cyclosporin A P17252 UniProt T-cell surface glycoprotein CD3 delta chain Proto-oncogene vav Ras-related C3 botulinum toxin substrate 1 Tyrosine-protein kinase Fyn P04234 UniProt 445643 PubChem-compound Interaction810 phosphoinositide (PIK) Complex activates Proto-oncogene vav Interaction812 Activated Ras-related C3 botulinum toxin substrate 1 activates Mitogen-activated protein kinase kinase kinase 1 without Magnesium Interaction811 Proto-oncogene vav activates Activated Ras-related C3 botulinum toxin substrate 1 Growth factor receptor-bound protein 2 P48736 UniProt Proto-oncogene c-Fos P20963 UniProt 6026790 PubChem-compound SMILES [O-]P([O-])([O-])=O Inositol 1,4,5-trisphosphate inositol_1,4,5-trisphosphate BioCyc 393220 ChemSpider T cell receptor alpha constant C00009 KEGG Compound T cell receptor alpha constant 1.0 Calmodulin(123) C00001 KEGG Compound HMDB0001429 HMDB Dual specificity mitogen-activated protein kinase kinase 4 Interaction820 Mitogen-activated protein kinase kinase kinase 1 without Magnesium activates Dual specificity mitogen-activated protein kinase kinase 4 and Phosphate Nuclear factor NF-kappa-B p105 subunit Interaction822 Dual specificity mitogen-activated protein kinase kinase 4 and Phosphate activates Mitogen-activated protein kinase 8 with Phosphate Transcription factor p65 CHEBI:18367 ChEBI Mitogen-activated protein kinase 8 Interaction825 Mitogen-activated protein kinase 3 with Phosphate activates Proto-oncogene c-Fos 1032 ChemSpider Q07889 UniProt Interaction824 Mitogen-activated protein kinase 8 with Phosphate activates Transcription factor AP-1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 388562 ChemSpider HMDB0000464 HMDB Interaction826 Mitogen-activated protein kinase 3 with Phosphate activates ETS domain-containing protein Elk-1 Interaction828 Linker for activation of T-cells family member 1 with Phosphate activates 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 without zinc P15498 UniProt P25963 UniProt Growth factor receptor-bound protein 2 24742074 PubChem-compound Nuclear factor NF-kappa-B p105 subunit GO:0005634 GENE ONTOLOGY Phosphatidylinositol 4,5-bisphosphate Nuclear factor of activated T-cells, cytoplasmic 3 Son of sevenless homolog 1 P19174 UniProt T Cell Receptor Signaling Pathway Nuclear factor of activated T-cells (Homo sapiens)_Phosphate Nuclear factor of activated T-cells, cytoplasmic 4 P07766 UniProt Son of sevenless homolog 1 Interaction830 Diacylglycerol activates Protein kinase C complex (Homo sapiens) + Calcium T-cell surface glycoprotein CD3 zeta chain RAS guanyl-releasing protein 1 Transcription factor AP-1 NFKB1,RELA complex Interaction832 Calcium activates Calmodulin(123) Interaction831 Protein kinase C complex (Homo sapiens) + Calcium activates NFKB1,NFKBIA,RELA,Ub Complex with Phosphate Diacylglycerol Interaction834 Tacrolimus inhibits protein phosphatase 3 Interaction833 Calmodulin(123) activates protein phosphatase 3 Interaction836 protein phosphatase 3 activates Nuclear factor of activated T-cells (Homo sapiens) + Phosphate Interaction835 Cyclosporin A inhibits protein phosphatase 3 Q02750 UniProt Calmodulin-1 1.0 14127-61-8 CAS SMILES [Ca++] protein phosphatase 3 1.0 GTPase HRas Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform O95267 UniProt Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform T-cell surface glycoprotein CD3 gamma chain P0DP23 UniProt Tyrosine-protein kinase Lck C47H80O19P3 Phosphatidylinositol 4,5-bisphosphate 1041.4507 P0DP24 UniProt P27361 UniProt P0DP25 UniProt RAF proto-oncogene serine/threonine-protein kinase PW067987 PathWhiz Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform C6H15O15P3 Inositol 1,4,5-trisphosphate 419.96237 GO:0005737 GENE ONTOLOGY CHEBI:29108 ChEBI C44H69NO12 Tacrolimus 803.482 CHEBI:61049 ChEBI Nuclear factor of activated T-cells, cytoplasmic 2 Protein kinase C beta type 1.0 1.0 Nuclear factor of activated T-cells, cytoplasmic 1 CPD-8587 BioCyc Transcription factor p65 C01245 KEGG Compound NFKB1,NFKBIA,RELA,Ub Complex with Phosphate P01848 UniProt Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform 104987-11-3 CAS Calcium 1.0 T cell receptor 1.0 NF-kappa-B inhibitor alpha Protein kinase C complex (Homo sapiens)_Calcium Calmodulin-3 Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform P05771 UniProt P05412 UniProt C37H70O5 Diacylglycerol 594.52234 Tyrosine-protein kinase Fyn P09693 UniProt C01375 KEGG Compound O95644 UniProt SMILES O[C@@H]1[C@H](O)[C@@H](OP(O)(O)=O)[C@H](OP(O)(O)=O)[C@@H](O)[C@@H]1OP(O)(O)=O Calmodulin-2 SMILES CO[C@@H]1C[C@@H](CC[C@H]1O)\C=C(/C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@]2(O)O[C@@H]([C@H](C[C@H]2C)OC)[C@H](C[C@@H](C)C\C(C)=C\[C@@H](CC=C)C(=O)C[C@H](O)[C@H]1C)OC Cytoplasm P01850 UniProt C62H111N11O12 Cyclosporin A 1201.8413 T-cell surface glycoprotein CD3 Ras-related C3 botulinum toxin substrate 1 Reaction115889 false NFKB1,NFKBIA,RELA,Ub Complex with Phosphate → NFKB1,RELA complex + NFKBIA with phosphate LEFT_TO_RIGHT RAS guanyl-releasing protein 1 Homo sapiens Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform Phosphatidylinositol 3-kinase regulatory subunit alpha 7732-18-5 CAS NF-kappa-B inhibitor alpha ETS domain-containing protein Elk-1 T cell receptor (Homo sapiens)_T-cell surface glycoprotein CD3 (Homo sapiens) T-cell surface glycoprotein CD3 zeta chain Reaction115852 false Phosphatidylinositol 4,5-bisphosphate → Inositol 1,4,5-trisphosphate LEFT_TO_RIGHT 439456 PubChem-compound Reaction115976 false Nuclear factor of activated T-cells (Homo sapiens) + Phosphate → Nuclear factor of activated T-cells + Phosphate LEFT_TO_RIGHT T-cell surface glycoprotein CD3 delta chain T-cell surface glycoprotein CD3 epsilon chain T cell receptor beta constant 1 P19838 UniProt T-cell surface glycoprotein CD3 gamma chain Dual specificity mitogen-activated protein kinase kinase 1 Mitogen-activated protein kinase kinase kinase 1 1.0 Mitogen-activated protein kinase 3 HMDB0001498 HMDB Polyubiquitin-C 9606 TAXONOMY Q13233 UniProt 962 PubChem-compound Protein kinase C complex ETS domain-containing protein Elk-1 P48454 UniProt C00076 KEGG Compound SHC-transforming protein 1 P62993 UniProt P45985 UniProt Q08209 UniProt P45983 UniProt CA%2b2 BioCyc Tyrosine-protein phosphatase non-receptor type 7 P16298 UniProt Tyrosine-protein phosphatase non-receptor type 7 Reaction115835 false 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 without zinc + Water → Phosphatidylinositol 4,5-bisphosphate LEFT_TO_RIGHT SMP0066977 SMPDB Ca Calcium 39.96259 HMDB0002111 HMDB Tyrosine-protein kinase ZAP-70 CHEBI:15377 ChEBI 14265-44-2 CAS T-cell surface glycoprotein CD3 epsilon chain 271 PubChem-compound RAF proto-oncogene serine/threonine-protein kinase Phosphate 1.0 Protein kinase C beta type 1.0 P27986 UniProt Reaction115846 false Phosphatidylinositol 4,5-bisphosphate → Diacylglycerol LEFT_TO_RIGHT Linker for activation of T-cells family member 1 Tacrolimus O43561 UniProt 1.0 Nuclear factor of activated T-cells, cytoplasmic 2 Interaction793 Antigen activates T cell receptor (Homo sapiens) + T-cell surface glycoprotein CD3 (Homo sapiens) Interaction792 T cell receptor (Homo sapiens) + T-cell surface glycoprotein CD3 (Homo sapiens) activates Tyrosine-protein kinase Lck Interaction795 T cell receptor (Homo sapiens) + T-cell surface glycoprotein CD3 (Homo sapiens) activates Tyrosine-protein kinase Fyn without Mg Interaction794 T cell receptor (Homo sapiens) + T-cell surface glycoprotein CD3 (Homo sapiens) activates Tyrosine-protein kinase ZAP-70 Interaction797 Tyrosine-protein kinase Fyn without Mg activates Proto-oncogene vav Interaction796 Tyrosine-protein kinase ZAP-70 activates Proto-oncogene vav Interaction799 Tyrosine-protein kinase ZAP-70 activates Linker for activation of T-cells family member 1 with Phosphate Nuclear factor of activated T-cells, cytoplasmic 1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 T-cell surface glycoprotein CD3 zeta chain P42336 UniProt H2O Water 18.010565 phosphoinositide (PIK) Complex Polyubiquitin-C Phosphatidylinositol 3-kinase regulatory subunit alpha Nucleus Dual specificity mitogen-activated protein kinase kinase 4 1061 PubChem-compound Mitogen-activated protein kinase 8 1.0 Linker for activation of T-cells family member 1 Transcription factor AP-1 SHC-transforming protein 1 GTPase HRas Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform Mitogen-activated protein kinase 3 1.0 Q13469 UniProt Tyrosine- protein kinase Lck Tyrosine- protein kinase ZAP-70 Tyrosine- protein kinase Fyn Proto-oncogene vav Linker for activation of T-cells family member 1 SHC- transforming protein 1 Growth factor receptor-bound protein 2 Son of sevenless homolog 1 RAS guanyl- releasing protein 1 GTPase HRas RAF proto-oncogene serine/threonine- protein kinase Dual specificity mitogen- activated protein kinase kinase 1 Mitogen- activated protein kinase 3 Tyrosine- protein phosphatase non-receptor type 7 Phosphatidylinositol- 4,5- bisphosphate 3-kinase catalytic subunit alpha isoform Phosphatidylinositol 3-kinase regulatory subunit alpha Phosphatidylinositol- 4,5- bisphosphate 3-kinase catalytic subunit gamma isoform Ras-related C3 botulinum toxin substrate 1 Mitogen- activated protein kinase kinase kinase 1 Dual specificity mitogen- activated protein kinase kinase 4 Mitogen- activated protein kinase 8 Transcription factor AP-1 Proto-oncogene c-Fos ETS domain- containing protein Elk-1 1- phosphatidylinositol 4,5- bisphosphate phosphodiesterase gamma-1 Polyubiquitin-C Transcription factor p65 Nuclear factor NF-kappa-B p105 subunit NF-kappa-B inhibitor alpha Calmodulin-3 Calmodulin-2 Calmodulin-1 Serine/threonine- protein phosphatase 2B catalytic subunit alpha isoform Serine/threonine- protein phosphatase 2B catalytic subunit beta isoform Serine/threonine- protein phosphatase 2B catalytic subunit gamma isoform Nuclear factor NF-kappa-B p105 subunit Transcription factor p65 NF-kappa-B inhibitor alpha Nuclear factor of activated T-cells, cytoplasmic 1 Nuclear factor of activated T-cells, cytoplasmic 2 Nuclear factor of activated T-cells, cytoplasmic 4 Nuclear factor of activated T-cells, cytoplasmic 3 T cell receptor alpha constant T cell receptor beta constant 1 T-cell surface glycoprotein CD3 zeta chain T-cell surface glycoprotein CD3 gamma chain T-cell surface glycoprotein CD3 delta chain T-cell surface glycoprotein CD3 epsilon chain Protein kinase C alpha type Protein kinase C beta type Nuclear factor of activated T-cells, cytoplasmic 1 Nuclear factor of activated T-cells, cytoplasmic 2 Nuclear factor of activated T-cells, cytoplasmic 4 Nuclear factor of activated T-cells, cytoplasmic 3 Diacylglycerol Ca + Tacrolimus Cyclosporin A H 2 O Phosphatidylinositol 4,5- bisphosphate Inositol 1,4,5- trisphosphate P i Phosphate Phosphate Phosphate Guanosine triphosphate Phosphate Phosphate Phosphate Calcium Phosphate Ca + P i Antigen IP3 triggers the release of Ca2+ from the ER Transcription factors increase gene expression by interacting with their regulatory sequences Cytoplasm Extracellular Space Nucleus Endoplasimc Reticulum
P0CG48 UniProt Tyrosine-protein kinase Lck 937 ChemSpider T cell receptor alpha constant Protein kinase C alpha type Proto-oncogene vav P63000 UniProt Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform Nuclear factor of activated T-cells, cytoplasmic 4 direct_interaction Nuclear factor of activated T-cells, cytoplasmic 3 P43403 UniProt Dual specificity mitogen-activated protein kinase kinase 1 SMILES O T cell receptor (Homo sapiens)_T-cell surface glycoprotein CD3 (Homo sapiens) Mitogen-activated protein kinase 8 1.0 Antigen P04049 UniProt Mitogen-activated protein kinase kinase kinase 1 P19419 UniProt SMILES CCCCCCCCCCCCCCCCCC(=O)OCC(COP([O-])(=O)O[C@@H]1[C@H](O)[C@H](O)[C@@H](OP([O-])([O-])=O)[C@H](OP([O-])([O-])=O)[C@H]1O)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC Water Q14934 UniProt T cell receptor beta constant 1 P29353 UniProt Protein kinase C alpha type 1.0 P35236 UniProt Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform P01100 UniProt 1.0 Tyrosine-protein kinase ZAP-70 HMDB0015002 HMDB CHEBI:16595 ChEBI T cell receptor Calmodulin-1 T-cell surface glycoprotein CD3 85166-31-0 CAS Calmodulin-2 T cell receptor beta constant 1 P06239 UniProt Calmodulin-3 Q12968 UniProt 1.0 T-cell surface glycoprotein CD3 epsilon chain T-cell surface glycoprotein CD3 delta chain T-cell surface glycoprotein CD3 gamma chain SMILES CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O)C(C)C SMILES CCCCCCCCCCCCCCCC(=O)OCC(CO)OC(=O)CCCCCCC\C=C\CCCCCCCC Nuclear factor of activated T-cells Antigen P01112 UniProt O4P Phosphate 94.95342 P06241 UniProt Interaction801 Linker for activation of T-cells family member 1 with Phosphate activates Growth factor receptor-bound protein 2 Interaction800 Linker for activation of T-cells family member 1 with Phosphate activates SHC-transforming protein 1 Interaction803 Son of sevenless homolog 1 activates RAS guanyl-releasing protein 1 Q04206 UniProt Interaction802 Linker for activation of T-cells family member 1 with Phosphate activates Son of sevenless homolog 1 Interaction805 GTPase HRas activates RAF proto-oncogene serine/threonine-protein kinase without zinc Interaction804 RAS guanyl-releasing protein 1 activates GTPase HRas Interaction807 Active Dual specificity mitogen-activated protein kinase kinase 1 activates Mitogen-activated protein kinase 3 with Phosphate Interaction806 RAF proto-oncogene serine/threonine-protein kinase without zinc activates Active Dual specificity mitogen-activated protein kinase kinase 1 Interaction809 GTPase HRas activates phosphoinositide (PIK) Complex 266 ChemSpider Interaction808 Tyrosine-protein phosphatase non-receptor type 7 inhibits Mitogen-activated protein kinase 3 with Phosphate Proto-oncogene c-Fos Cyclosporin A P17252 UniProt T-cell surface glycoprotein CD3 delta chain Proto-oncogene vav Ras-related C3 botulinum toxin substrate 1 Tyrosine-protein kinase Fyn P04234 UniProt 445643 PubChem-compound Interaction810 phosphoinositide (PIK) Complex activates Proto-oncogene vav Interaction812 Activated Ras-related C3 botulinum toxin substrate 1 activates Mitogen-activated protein kinase kinase kinase 1 without Magnesium Interaction811 Proto-oncogene vav activates Activated Ras-related C3 botulinum toxin substrate 1 Growth factor receptor-bound protein 2 P48736 UniProt Proto-oncogene c-Fos P20963 UniProt 6026790 PubChem-compound SMILES [O-]P([O-])([O-])=O Inositol 1,4,5-trisphosphate inositol_1,4,5-trisphosphate BioCyc 393220 ChemSpider T cell receptor alpha constant C00009 KEGG Compound T cell receptor alpha constant 1.0 Calmodulin(123) C00001 KEGG Compound HMDB0001429 HMDB Dual specificity mitogen-activated protein kinase kinase 4 Interaction820 Mitogen-activated protein kinase kinase kinase 1 without Magnesium activates Dual specificity mitogen-activated protein kinase kinase 4 and Phosphate Nuclear factor NF-kappa-B p105 subunit Interaction822 Dual specificity mitogen-activated protein kinase kinase 4 and Phosphate activates Mitogen-activated protein kinase 8 with Phosphate Transcription factor p65 CHEBI:18367 ChEBI Mitogen-activated protein kinase 8 Interaction825 Mitogen-activated protein kinase 3 with Phosphate activates Proto-oncogene c-Fos 1032 ChemSpider Q07889 UniProt Interaction824 Mitogen-activated protein kinase 8 with Phosphate activates Transcription factor AP-1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 388562 ChemSpider HMDB0000464 HMDB Interaction826 Mitogen-activated protein kinase 3 with Phosphate activates ETS domain-containing protein Elk-1 Interaction828 Linker for activation of T-cells family member 1 with Phosphate activates 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 without zinc P15498 UniProt P25963 UniProt Growth factor receptor-bound protein 2 24742074 PubChem-compound Nuclear factor NF-kappa-B p105 subunit GO:0005634 GENE ONTOLOGY Phosphatidylinositol 4,5-bisphosphate Nuclear factor of activated T-cells, cytoplasmic 3 Son of sevenless homolog 1 P19174 UniProt T Cell Receptor Signaling Pathway Nuclear factor of activated T-cells (Homo sapiens)_Phosphate Nuclear factor of activated T-cells, cytoplasmic 4 P07766 UniProt Son of sevenless homolog 1 Interaction830 Diacylglycerol activates Protein kinase C complex (Homo sapiens) + Calcium T-cell surface glycoprotein CD3 zeta chain RAS guanyl-releasing protein 1 Transcription factor AP-1 NFKB1,RELA complex Interaction832 Calcium activates Calmodulin(123) Interaction831 Protein kinase C complex (Homo sapiens) + Calcium activates NFKB1,NFKBIA,RELA,Ub Complex with Phosphate Diacylglycerol Interaction834 Tacrolimus inhibits protein phosphatase 3 Interaction833 Calmodulin(123) activates protein phosphatase 3 Interaction836 protein phosphatase 3 activates Nuclear factor of activated T-cells (Homo sapiens) + Phosphate Interaction835 Cyclosporin A inhibits protein phosphatase 3 Q02750 UniProt Calmodulin-1 1.0 14127-61-8 CAS SMILES [Ca++] protein phosphatase 3 1.0 GTPase HRas Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform O95267 UniProt Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform T-cell surface glycoprotein CD3 gamma chain P0DP23 UniProt Tyrosine-protein kinase Lck C47H80O19P3 Phosphatidylinositol 4,5-bisphosphate 1041.4507 P0DP24 UniProt P27361 UniProt P0DP25 UniProt RAF proto-oncogene serine/threonine-protein kinase PW067987 PathWhiz Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform C6H15O15P3 Inositol 1,4,5-trisphosphate 419.96237 GO:0005737 GENE ONTOLOGY CHEBI:29108 ChEBI C44H69NO12 Tacrolimus 803.482 CHEBI:61049 ChEBI Nuclear factor of activated T-cells, cytoplasmic 2 Protein kinase C beta type 1.0 1.0 Nuclear factor of activated T-cells, cytoplasmic 1 CPD-8587 BioCyc Transcription factor p65 C01245 KEGG Compound NFKB1,NFKBIA,RELA,Ub Complex with Phosphate P01848 UniProt Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform 104987-11-3 CAS Calcium 1.0 T cell receptor 1.0 NF-kappa-B inhibitor alpha Protein kinase C complex (Homo sapiens)_Calcium Calmodulin-3 Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform P05771 UniProt P05412 UniProt C37H70O5 Diacylglycerol 594.52234 Tyrosine-protein kinase Fyn P09693 UniProt C01375 KEGG Compound O95644 UniProt SMILES O[C@@H]1[C@H](O)[C@@H](OP(O)(O)=O)[C@H](OP(O)(O)=O)[C@@H](O)[C@@H]1OP(O)(O)=O Calmodulin-2 SMILES CO[C@@H]1C[C@@H](CC[C@H]1O)\C=C(/C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@]2(O)O[C@@H]([C@H](C[C@H]2C)OC)[C@H](C[C@@H](C)C\C(C)=C\[C@@H](CC=C)C(=O)C[C@H](O)[C@H]1C)OC Cytoplasm P01850 UniProt C62H111N11O12 Cyclosporin A 1201.8413 T-cell surface glycoprotein CD3 Ras-related C3 botulinum toxin substrate 1 Reaction115889 false NFKB1,NFKBIA,RELA,Ub Complex with Phosphate → NFKB1,RELA complex + NFKBIA with phosphate LEFT_TO_RIGHT RAS guanyl-releasing protein 1 Homo sapiens Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform Phosphatidylinositol 3-kinase regulatory subunit alpha 7732-18-5 CAS NF-kappa-B inhibitor alpha ETS domain-containing protein Elk-1 T cell receptor (Homo sapiens)_T-cell surface glycoprotein CD3 (Homo sapiens) T-cell surface glycoprotein CD3 zeta chain Reaction115852 false Phosphatidylinositol 4,5-bisphosphate → Inositol 1,4,5-trisphosphate LEFT_TO_RIGHT 439456 PubChem-compound Reaction115976 false Nuclear factor of activated T-cells (Homo sapiens) + Phosphate → Nuclear factor of activated T-cells + Phosphate LEFT_TO_RIGHT T-cell surface glycoprotein CD3 delta chain T-cell surface glycoprotein CD3 epsilon chain T cell receptor beta constant 1 P19838 UniProt T-cell surface glycoprotein CD3 gamma chain Dual specificity mitogen-activated protein kinase kinase 1 Mitogen-activated protein kinase kinase kinase 1 1.0 Mitogen-activated protein kinase 3 HMDB0001498 HMDB Polyubiquitin-C 9606 TAXONOMY Q13233 UniProt 962 PubChem-compound Protein kinase C complex ETS domain-containing protein Elk-1 P48454 UniProt C00076 KEGG Compound SHC-transforming protein 1 P62993 UniProt P45985 UniProt Q08209 UniProt P45983 UniProt CA%2b2 BioCyc Tyrosine-protein phosphatase non-receptor type 7 P16298 UniProt Tyrosine-protein phosphatase non-receptor type 7 Reaction115835 false 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 without zinc + Water → Phosphatidylinositol 4,5-bisphosphate LEFT_TO_RIGHT SMP0066977 SMPDB Ca Calcium 39.96259 HMDB0002111 HMDB Tyrosine-protein kinase ZAP-70 CHEBI:15377 ChEBI 14265-44-2 CAS T-cell surface glycoprotein CD3 epsilon chain 271 PubChem-compound RAF proto-oncogene serine/threonine-protein kinase Phosphate 1.0 Protein kinase C beta type 1.0 P27986 UniProt Reaction115846 false Phosphatidylinositol 4,5-bisphosphate → Diacylglycerol LEFT_TO_RIGHT Linker for activation of T-cells family member 1 Tacrolimus O43561 UniProt 1.0 Nuclear factor of activated T-cells, cytoplasmic 2 Interaction793 Antigen activates T cell receptor (Homo sapiens) + T-cell surface glycoprotein CD3 (Homo sapiens) Interaction792 T cell receptor (Homo sapiens) + T-cell surface glycoprotein CD3 (Homo sapiens) activates Tyrosine-protein kinase Lck Interaction795 T cell receptor (Homo sapiens) + T-cell surface glycoprotein CD3 (Homo sapiens) activates Tyrosine-protein kinase Fyn without Mg Interaction794 T cell receptor (Homo sapiens) + T-cell surface glycoprotein CD3 (Homo sapiens) activates Tyrosine-protein kinase ZAP-70 Interaction797 Tyrosine-protein kinase Fyn without Mg activates Proto-oncogene vav Interaction796 Tyrosine-protein kinase ZAP-70 activates Proto-oncogene vav Interaction799 Tyrosine-protein kinase ZAP-70 activates Linker for activation of T-cells family member 1 with Phosphate Nuclear factor of activated T-cells, cytoplasmic 1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 T-cell surface glycoprotein CD3 zeta chain P42336 UniProt H2O Water 18.010565 phosphoinositide (PIK) Complex Polyubiquitin-C Phosphatidylinositol 3-kinase regulatory subunit alpha Nucleus Dual specificity mitogen-activated protein kinase kinase 4 1061 PubChem-compound Mitogen-activated protein kinase 8 1.0 Linker for activation of T-cells family member 1 Transcription factor AP-1 SHC-transforming protein 1 GTPase HRas Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform Mitogen-activated protein kinase 3 1.0 Q13469 UniProt LCK ZAP70 FYN VAV1 LAT Unknown GRB2 SOS1 RASGRP1 HRAS RAF1 MAP2K1 MAPK3 PTPN7 PIK3CA PIK3R1 PIK3CG RAC1 MAP3K1 MAP2K4 MAPK8 JUN FOS ELK1 PLCG1 UBC RELA NFKB1 NFKBIA CALM3 CALM2 CALM1 PPP3CA PPP3CB PPP3CC NFKB1 RELA NFKBIA NFATC1 NFATC2 NFATC4 NFATC3 TRAC TRBC1 CD247 CD3G CD3D CD3E PRKCA PRKCB NFATC1 NFATC2 NFATC4 NFATC3 Diacylglycerol Calcium Tacrolimus Cyclosporin A Water Phosphatidylinositol 4,5- bisphosphate Inositol 1,4,5- trisphosphate Phosphate Calcium Phosphate Antigen