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Tyrosine- protein kinase Lck Tyrosine- protein kinase ZAP-70 Tyrosine- protein kinase Fyn Proto-oncogene vav Linker for activation of T-cells family member 1 SHC- transforming protein 1 Growth factor receptor-bound protein 2 Son of sevenless homolog 1 RAS guanyl- releasing protein 1 GTPase HRas RAF proto-oncogene serine/threonine- protein kinase Dual specificity mitogen- activated protein kinase kinase 1 Mitogen- activated protein kinase 3 Tyrosine- protein phosphatase non-receptor type 7 Phosphatidylinositol- 4,5- bisphosphate 3-kinase catalytic subunit alpha isoform Phosphatidylinositol 3-kinase regulatory subunit alpha Phosphatidylinositol- 4,5- bisphosphate 3-kinase catalytic subunit gamma isoform Ras-related C3 botulinum toxin substrate 1 Mitogen- activated protein kinase kinase kinase 1 Dual specificity mitogen- activated protein kinase kinase 4 Mitogen- activated protein kinase 8 Transcription factor AP-1 Proto-oncogene c-Fos ETS domain- containing protein Elk-1 1- phosphatidylinositol 4,5- bisphosphate phosphodiesterase gamma-1 Polyubiquitin-C Transcription factor p65 Nuclear factor NF-kappa-B p105 subunit NF-kappa-B inhibitor alpha Calmodulin-3 Calmodulin-2 Calmodulin-1 Serine/threonine- protein phosphatase 2B catalytic subunit alpha isoform Serine/threonine- protein phosphatase 2B catalytic subunit beta isoform Serine/threonine- protein phosphatase 2B catalytic subunit gamma isoform Nuclear factor NF-kappa-B p105 subunit Transcription factor p65 NF-kappa-B inhibitor alpha Nuclear factor of activated T-cells, cytoplasmic 1 Nuclear factor of activated T-cells, cytoplasmic 2 Nuclear factor of activated T-cells, cytoplasmic 4 Nuclear factor of activated T-cells, cytoplasmic 3 T cell receptor alpha constant T cell receptor beta constant 1 T-cell surface glycoprotein CD3 zeta chain T-cell surface glycoprotein CD3 gamma chain T-cell surface glycoprotein CD3 delta chain T-cell surface glycoprotein CD3 epsilon chain Protein kinase C alpha type Protein kinase C beta type Nuclear factor of activated T-cells, cytoplasmic 1 Nuclear factor of activated T-cells, cytoplasmic 2 Nuclear factor of activated T-cells, cytoplasmic 4 Nuclear factor of activated T-cells, cytoplasmic 3 Diacylglycerol Ca + Tacrolimus Cyclosporin A H 2 O Phosphatidylinositol 4,5- bisphosphate Inositol 1,4,5- trisphosphate P i Phosphate Phosphate Phosphate Guanosine triphosphate Phosphate Phosphate Phosphate Calcium Phosphate Ca + P i Antigen IP3 triggers the release of Ca2+ from the ER Transcription factors increase gene expression by interacting with their regulatory sequences Cytoplasm Extracellular Space Nucleus Endoplasimc Reticulum
LCK ZAP70 FYN VAV1 LAT Unknown GRB2 SOS1 RASGRP1 HRAS RAF1 MAP2K1 MAPK3 PTPN7 PIK3CA PIK3R1 PIK3CG RAC1 MAP3K1 MAP2K4 MAPK8 JUN FOS ELK1 PLCG1 UBC RELA NFKB1 NFKBIA CALM3 CALM2 CALM1 PPP3CA PPP3CB PPP3CC NFKB1 RELA NFKBIA NFATC1 NFATC2 NFATC4 NFATC3 TRAC TRBC1 CD247 CD3G CD3D CD3E PRKCA PRKCB NFATC1 NFATC2 NFATC4 NFATC3 Diacylglycerol Calcium Tacrolimus Cyclosporin A Water Phosphatidylinositol 4,5- bisphosphate Inositol 1,4,5- trisphosphate Phosphate Calcium Phosphate Antigen