Browsing Pathways
Showing 711 -
720 of 605359 pathways
SMPDB ID | Pathway Name and Description | Pathway Class | Chemical Compounds | Proteins |
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SMP0126467View Pathway |
Ticlopidine Action Pathway (new)Ticlopidine is a platelet aggregation inhibitor also known as Ticlid, used to prevent strokes or transient ischemic attacks. It is administered orally as a prodrug that is metabolized into its active form, it then goes on to prevent the binding of ADP to the P2Y receptor. With ADP activation of the receptor inhibited this leads to impaired platelet aggregation and activation. Ticlopidine should be taken with a high fat meal, as it increases absorption of the drug and helps reduce any gastrointestinal irritation.
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Drug Action
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SMP0000261View Pathway |
Ticlopidine Action PathwayTiclopidine, marketed as Ticlid, is an antiplatelet drug that targets the P2Y12 receptor of platelets. Ticlopidine is taken orally and is a prodrug that must be metabolically activated before it can be effective. It first enters the liver and enters the endoplasmic reticulum where it is metabolized to form the active metabolite. First, it is catalyzed by cytochromes P450 2C19, 2B6 and 1A2 into 2-oxoclopidogrel. Secondly, it is processed by cytochromes P450 2B6, 2C9, 2C19, 3A4, 3A5, and serum paraoxonase/arylesterase 1 into the active metabolite of clopidogrel. The active metabolite of clopidogrel then enters the blood stream, where it binds irreversibly to the P2Y purinoreceptor 12 on the surface of platelet cells, preventing ADP from binding to and activating it. Clopidogrel prevents the activation of the Gi protein associated with the P2Y12 receptor from inactivating adenylate cyclase in the platelet, leading to a buildup of cAMP. This cAMP then activates calcium efflux pumps, preventing calcium buildup in the platelet, which would cause activation, and later, aggregation.
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Drug Action
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SMP0130317View Pathway |
Tick-borne encephalitis vaccine (whole virus, inactivated) Drug Metabolism |
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SMP0174561View Pathway |
Ticarcillin Predicted Metabolism PathwayMetabolites of Ticarcillin are predicted with biotransformer.
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SMP0143806View Pathway |
Ticarcillin Drug Metabolism Action Pathway |
Drug Action
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SMP0174847View Pathway |
Ticagrelor Predicted Metabolism PathwayMetabolites of Ticagrelor are predicted with biotransformer.
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SMP0144173View Pathway |
Ticagrelor Drug Metabolism Action Pathway |
Drug Action
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SMP0126465View Pathway |
Ticagrelor Action PathwayTicagrelor also known via brand names Brilinta or Brilique, is a platelet inhibitor used to prevent infarction, stroke or cardiovascular death. Once administered orally it travels to the bloodstream and acts on platelets' P2Y receptors which inhibits the formation of thromboses. An activated P2Y receptor couples with guanine nucleotide-binding protein subunit i2 that inhibits adenylyl cyclase. By inhibiting adenylyl cyclase, it stops the formation of cAMP, leading to a stop of calcium efflux causing platelet aggregation and activation. Grapefruit products should be avoided as it inhibits the CYP3A4 metabolism of ticagrelor and cause an increase in the drug which may lead to an overdose. Herbs and supplements with anticoagulant and antiplatelet activity should be avoided such as garlic, ginger, bilberry, danshen, piracetam and ginkgo biloba. St. John's Wort induces the CYP3A4 metabolism of the drug and will reduce its efficacy and concentration.
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Drug Action
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SMP0129601View Pathway |
Tibulizumab Drug Metabolism |
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SMP0144283View Pathway |
Tibolone Drug Metabolism Action Pathway |
Drug Action
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Showing 711 -
720 of 65006 pathways