PathWhiz

PathWhiz ID	Pathway	Meta Data
PW176374 View Pathway	metabolic Amisulpride Predicted Metabolism Pathway Homo sapiens Metabolites of Amisulpride are predicted with biotransformer. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Omolola Created On: December 07, 2023 at 16:27 Last Updated: December 07, 2023 at 16:27
PW145702 View Pathway	drug action Amisulpride Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 16:26 Last Updated: October 07, 2023 at 16:26
PW128190 View Pathway	drug action Amisulpride Dopamine Antagonist Action Pathway Homo sapiens Amisulpride, a substituted benzamide derivative, is a second-generation (atypical) antipsychotic. Amisulpride is a selective dopamine D2 and D3 receptor antagonist with no affinity towards other dopamine receptor subtypes. At low doses, it enhances dopaminergic neurotransmission by preferentially blocking presynaptic dopamine D2/D3 autoreceptors. At higher doses, amisupride antagonises postsynaptic dopamine D2 and D3 receptors, preferentially in the limbic system rather than the striatum, thereby reducing dopaminergic transmission. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Omolola Created On: July 31, 2023 at 10:26 Last Updated: July 31, 2023 at 10:26
PW123961 View Pathway	drug action Amiodarone Action Pathway (New) Homo sapiens Amiodarone is a class III antiarrhythmic drug used for treating ventricular arrythmias. It is administered orally or intravenously. Amiodarone targets the cardiac myocytes where it blocks the inward rectifying potassium channels. This potassium is responsible for phase 3 of the action potential. During phase 3, K+ goes out of the cell to allow repolarization. In the presence of amiodarone, K+ accumulates in the cell since the potassium channels are blocked by amiodarone. This causes the repolarization phase, and thus, the action potential duration to be prolonged. The excitability of the cell is reduced and this leads to a slowing of the heart rate. The QRS duration is increased and the QT interval is also prolonged. These effects on the action potentials and the heart rate therefore mean that abnormal heart rhythms like tachyarrhythmias are less likely to occur. Amiodarone may have adverse effects such as thyrotoxicosis or hypothyroidism, tremor, uncontrollable and unusual movement of the body, dizziness, headache, nausea and vomiting, constipation, blurred vision, due to its effects on other targets such as beta-adrenergic receptors, sodium channels, and calcium channels. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Karxena Harford Created On: July 06, 2020 at 02:19 Last Updated: July 06, 2020 at 02:19
PW000642 View Pathway	drug action Amiodarone Action Pathway Homo sapiens Amiodarone, trade name Cordarone and Nexterone, is an antianginal and a class III antiarrhythmic drug prescribed to treat irregular heart rhythms. The drug inhibits Na,K-activated myocardial adenosine triphosphatase, calcium and potassium channels and beta adrenergic receptors causing an increase in ventricular and atrial muscle action duration. This inhibition causes prevents repolarization of the cells causing heart rate to decrease and vascular resistance to decrease. Amiodarone exerts its antiarrhythmic effect by prolonging the duration of myocardial cell-action potentials. Amiodarone is unique to other class III antiarrhythmic drugs due to its effect on beta adrenergic receptors, calcium channels and sodium channels. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: WishartLab Created On: April 20, 2014 at 16:05 Last Updated: April 20, 2014 at 16:05
PW144362 View Pathway	drug action Aminosalicylic acid Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 13:28 Last Updated: October 07, 2023 at 13:28
PW002039 View Pathway	metabolic Aminopropylcadaverine Biosynthesis Escherichia coli Aminopropylcadaverine, a polyamine, is the final product of aminopropylcadaverine biosynthesis pathway. Polyamines are involved in protein synthesis, DNA and RNA related processes, as well as the facilitation of cell stress resistance and membrane integrity; therefore polyamines are essential for cell growth. In this pathway, L-lysine is produced by lysine biosynthesis, then lysine decarboxylase will convert L-lysine into cadaverine. In the final step, spermidine synthase will catalyze cadaverine and decarboxy-SAM to aminopropylcadaverine as well as 5'-Methylthioadenosine. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ana Marcu Created On: October 07, 2015 at 14:00 Last Updated: October 07, 2015 at 14:00
PW123536 View Pathway	metabolic Aminopropylcadaverine Biosynthesis Pseudomonas aeruginosa Aminopropylcadaverine, a polyamine, is the final product of aminopropylcadaverine biosynthesis pathway. Polyamines are involved in protein synthesis, DNA and RNA related processes, as well as the facilitation of cell stress resistance and membrane integrity; therefore polyamines are essential for cell growth. In this pathway, L-lysine is produced by lysine biosynthesis, then lysine decarboxylase will convert L-lysine into cadaverine. In the final step, spermidine synthase will catalyze cadaverine and decarboxy-SAM to aminopropylcadaverine as well as 5'-Methylthioadenosine. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ana Marcu Created On: August 12, 2019 at 22:28 Last Updated: August 12, 2019 at 22:28
PW145309 View Pathway	drug action Aminophylline Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 15:31 Last Updated: October 07, 2023 at 15:31
PW132302 View Pathway	metabolic Aminophylline Drug Metabolism Homo sapiens Aminophylline is a drug that is not metabolized by the human body as determined by current research and biotransformer analysis. Aminophylline passes through the liver and is then excreted from the body mainly through the kidney. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: September 21, 2023 at 20:45 Last Updated: September 21, 2023 at 20:45