PathWhiz

PathWhiz ID	Pathway	Meta Data
PW146956 View Pathway	drug action Maralixibat Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 19:26 Last Updated: October 07, 2023 at 19:26
PW176087 View Pathway	metabolic Maralixibat Predicted Metabolism Pathway new Homo sapiens Metabolites of Maralixibat are predicted with biotransformer. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Omolola Created On: November 29, 2023 at 13:51 Last Updated: November 29, 2023 at 13:51
PW127558 View Pathway	drug action Maraviroc Action Pathway Homo sapiens Maraviroc, known by the brand name Selzentry or Celsentri, is a chemokine receptor antagonist drug used to treat HIV-1 infections. It was developed by the drug company Pfizer. Maraviroc blocks HIV entry to the host cell by selectively binding to the human chemokine receptor (CCR5) present on the membrane of CD4 cells (T cells). This prevents the interaction of HIV-1 gp120 and CCR5 which is necessary for HIV to enter the cell and replicate. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: May 05, 2023 at 12:35 Last Updated: May 05, 2023 at 12:35
PW145586 View Pathway	drug action Maraviroc Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 16:08 Last Updated: October 07, 2023 at 16:08
PW176337 View Pathway	metabolic Maraviroc Predicted Metabolism Pathway Homo sapiens Metabolites of sildenafil are predicted with biotransformer. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Omolola Created On: December 07, 2023 at 15:14 Last Updated: December 07, 2023 at 15:14
PW127766 View Pathway	drug action Maribavir Action Pathway Homo sapiens Maribavir, known as the brand name Livtencity, is a benzimidazole riboside that inhibits cytomegalovirus (CMV) pUL97 kinase used to treat refractory post-transplant CMV infections. Human cytomegalovirus is a herpesvirus that is a common infection following stem cell or organ transplants. Like other herpesviruses, it tends to presist in the host and become reactivated under immunosuppressive conditions, such as during a transplant. Maribavir competitively inhibits human CMV pUL97 viral protein kinase which plays a role in viral egress, and viral replication or regulation of hot cell cycle progression. It has been found to participate in the acquisition of tegument during virion morphogenesis. It has also been found to phosphorylate the nuclear egress complex, which allows to viral release from the host cell. It also plays a role in the phosphorylation of Lamins-A/C and DNA polymerase. Lamin-A/C contributes to viral release with the nuclear egress complex, while DNA polymerase is essential in DNA replication. The inhibition of pUL97 viral protein kinase results in a viable, but severely defective virus upon replication. The exact reasons for this remain poorly defined. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: May 31, 2023 at 11:01 Last Updated: May 31, 2023 at 11:01
PW145690 View Pathway	drug action Maribavir Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 16:24 Last Updated: October 07, 2023 at 16:24
PW144310 View Pathway	drug action Masoprocol Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 13:22 Last Updated: October 07, 2023 at 13:22
PW123643 View Pathway	metabolic Mattinson photorespiration Zea mays BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Guest: Anonymous Created On: November 08, 2019 at 12:50 Last Updated: November 08, 2019 at 12:50
PW146899 View Pathway	drug action Mavacamten Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 19:18 Last Updated: October 07, 2023 at 19:18