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Showing 1 - 10 of 605359 pathways
SMPDB ID Pathway Name and Description Pathway Class Chemical Compounds Proteins

SMP0121057

Pw122325 View Pathway

Bloch Pathway (Cholesterol Biosynthesis)

The Bloch pathway, named after Konrad Bloch, is the pathway following the mevalonate pathway occurring within the cell to complete cholesterol biosynthesis. Cholesterol is a necessary metabolite that helps create many essential hormones within the human body. This pathway, combined with the m (more)
Metabolic

SMP0121012

Pw122279 View Pathway

Kidney Function - Distal Convoluted Tubule

The distal convoluted tubule of the nephron is the part of the kidney between the loop of henle and the collecting duct. When renin is released from the kidneys, it causes the activation of angiotensin I in the blood circulation which is cleaved to become angiotensin II. Angiotensin II stimul (more)
Physiological

SMP0121128

Pw122406 View Pathway

Pancreas Function - Delta Cell

Pancreatic delta cells produce somatostatin which functions to inhibit glucagon, insulin, and itself. Somatostatin is stored in granules in the delta cell and is released in response to an increase in blood sugar, calcium, and blood amino acids during absorption of a meal. In the process of s (more)
Physiological

SMP0000464

Pw000047 View Pathway

Vitamin K Metabolism

Vitamin K describes a group of lipophilic, hydrophobic vitamins that exist naturally in two forms (and synthetically in three others): vitamin K1, which is found in plants, and vitamin K2, which is synthesized by bacteria. Vitamin K is an important dietary component because it is necessary as (more)
Metabolic

SMP0000030

Pw000155 View Pathway

Oxidation of Branched-Chain Fatty Acids

In the majority of organisms, fatty acid degradation occurs mostly through the beta-oxidation cycle. In plants, this cycle only happens in the peroxisome, while in mammals this cycle happens in both the peroxisomes and mitochondria. Unfortunately, traditional fatty acid oxidation does not wor (more)
Metabolic

SMP0000456

Pw000167 View Pathway

Fatty Acid Biosynthesis

The biosynthesis of fatty acids primarily occurs in liver and lactating mammary glands. The entire synthesis process which produces palmitic acid occurs on a multifunctional dimeric protein Fatty Acid Synthase (FA) in the cytosol. The production of palmitic acid can be summarized as the succe (more)
Metabolic

SMP0000070

Pw000035 View Pathway

Riboflavin Metabolism

Riboflavin (vitamin B2) is an important part of the enzyme cofactors FAD (flavin-adenine dinucleotide) and FMN (flavin mononucleotide). The name "riboflavin" actually comes from "ribose" and "flavin". Like the other B vitamins, riboflavin is needed for the breaking down and processing of keto (more)
Metabolic

SMP0000129

Pw000030 View Pathway

Malate-Aspartate Shuttle

The malate-aspartate shuttle system, also called the malate shuttle, is an essential system used by mitochondria, that allows electrons to move across the impermeable membrane between the cytosol and the mitochondrial matrix. The electrons are created during glycolysis, and are needed for oxi (more)
Metabolic

SMP0014212

Pw015076 View Pathway

Phosphatidylcholine Biosynthesis

Phosphatidylcholines (PC) are a class of phospholipids that incorporate a phosphocholine headgroup into a diacylglycerol backbone. They are the most abundant phospholipid in eukaryotic cell membranes and has both structural and signalling roles. In eukaryotes, there exist two phosphatidylchol (more)
Metabolic

SMP0030406

Pw031290 View Pathway

Androstenedione Metabolism

Androstenedione is an endogenous weak androgen steroid hormone that is a precursor of testosterone and other androgens, as well as of estrogens like estrone . Its metabolism occurs primarily in the endoplasmic reticulum (membrane-associated enzymes are coloured dark green in the image). Conve (more)
Metabolic
Showing 1 - 10 of 103275 pathways