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Beta-Ala-His
dipeptidase
Carnosine
synthase 1
Protein arginine
N-
methyltransferase
3
Histidine
decarboxylase
Histamine N-
methyltransferase
Amine oxidase
[flavin-
containing] A
Aldehyde
dehydrogenase,
dimeric
NADP-preferring
Aldehyde
dehydrogenase,
mitochondrial
Histidine
ammonia-lyase
Urocanate
hydratase
Probable
imidazolonepropionase
Formimidoyltransferase-
cyclodeaminase
Amiloride-
sensitive amine
oxidase [copper-
containing]
Carnosine N-
methyltransferase
Carnosine
synthase 1
cytosolic
non-specific
dipeptidase
Probable
histidine--tRNA
ligase,
mitochondrial
Histidine--tRNA
ligase,
cytoplasmic
L-Glutamic acid
Carnosine
H
2
O
β-Alanine
L-Histidine
ATP
β-Alanine
ADP
P
i
S-
Adenosylmethionine
3-Methylhistidine
S-
Adenosylhomocysteine
Histamine
CO
2
S-
Adenosylmethionine
S-
Adenosylhomocysteine
1-Methylhistamine
H
2
O
O
2
Methylimidazole
acetaldehyde
NH
3
H
2
O
2
NADP
H
2
O
Methylimidazoleacetic
acid
NADPH
H
+
Imidazole-4-
acetaldehyde
NAD
H
2
O
Imidazoleacetic
acid
NADH
H
+
NH
3
Urocanic acid
4-Imidazolone-
5-propionic acid
H
2
O
H
2
O
Formiminoglutamic
acid
Tetrahydrofolic
acid
5-
Formiminotetrahydrofolic
acid
H
2
O
O
2
NH
3
H
2
O
2
S-
Adenosylmethionine
S-
Adenosylhomocysteine
Anserine
ATP
1-Methylhistidine
β-Alanine
ADP
P
i
H
2
O
β-Alanine
ATP
AMP
PP
i
ATP
AMP
PP
i
Pyridoxal
5'-phosphate
tRNA(His)
L- Histidyl-
tRNA(His)
tRNA(His)
Glutamate
Metabolism
Zinc (II) ion
Manganese
FAD
NAD
Zinc (II) ion
Pyridoxal
5'-phosphate
Copper
Calcium
Topaquinone
Manganese
Manganese
Intracellular Space
Extracellular Space
Mitochondria
Mitochondria