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CAD protein CAD protein CAD protein Dihydroorotate dehydrogenase (quinone), mitochondrial Uridine monophosphate synthetase isoform A Uridine monophosphate synthetase isoform A Soluble calcium- activated nucleotidase 1 UMP-CMP kinase 2, mitochondrial Nucleoside diphosphate kinase 6 Soluble calcium- activated nucleotidase 1 GTP:AMP phosphotransferase, mitochondrial Inosine triphosphate pyrophosphatase CTP synthase 1 Soluble calcium- activated nucleotidase 1 Nucleoside diphosphate kinase 6 Soluble calcium- activated nucleotidase 1 UMP-CMP kinase 2, mitochondrial Cytosolic purine 5'-nucleotidase Guanine deaminase Cytosolic purine 5'-nucleotidase Uridine phosphorylase 2 Dihydropyrimidine dehydrogenase [NADP(+)] Dihydropyrimidinase Beta- ureidopropionase Ribonucleoside- diphosphate reductase large subunit Nucleoside diphosphate kinase 6 UMP-CMP kinase 2, mitochondrial Cytosolic purine 5'-nucleotidase Uridine- cytidine kinase-like 1 Cytidine deaminase Thymidine phosphorylase Deoxycytidylate deaminase Thymidine kinase, cytosolic Thymidylate synthase Thymidylate synthase Soluble calcium- activated nucleotidase 1 Nucleoside diphosphate kinase 6 Soluble calcium- activated nucleotidase 1 Cytosolic purine 5'-nucleotidase Thymidine kinase, cytosolic Thymidine phosphorylase Dihydropyrimidine dehydrogenase [NADP(+)] Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial Nucleoside diphosphate kinase 6 Thymidylate synthase Ribonucleoside- diphosphate reductase large subunit Uridine- cytidine kinase-like 1 Beta- ureidopropionase Dihydropyrimidinase Uridine triphosphate Cytidine triphosphate Uridine 5'-diphosphate CDP dCTP Thymidine 5'-triphosphate β-Alanine L-Glutamine Carbamoyl phosphate Phosphoribosyl pyrophosphate 3-Aminoisobutanoic acid ATP H2O HCO3- ADP Pi Ureidosuccinic acid L-Dihydroorotic acid Quinone Accumulation Orotic acid Orotidylic acid Uridine 5'-monophosphate H2O Pi ATP ADP ADP ATP H2O Pi ADP AMP H2O PPi ATP ADP Pi dCTP H2O Pi ADP ATP H2O Cytidine monophosphate Pi ADP ATP H2O Cytidine Pi H2O Uridine NH3 H2O Pi Pi Accumulation Uracil Ribose 1-phosphate NADP Dihydrouracil NADPH H2O Ureidopropionic acid H2O NH3 CO2 H2O dCDP ATP ADP dCMP ATP ADP H2O Deoxycytidine Pi ATP ADP H2O Deoxyuridine NH3 Pi Deoxyribose 1-phosphate