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Potassium-
transporting
ATPase subunit
beta
Potassium-
transporting
ATPase alpha
chain 1
Histamine H2
receptor
Gastrin
Gastrin/cholecystokinin
type B receptor
Muscarinic
acetylcholine
receptor M3
Potassium-
transporting
ATPase subunit
beta
Potassium-
transporting
ATPase alpha
chain 1
Somatostatin
Somatostatin
receptor type 2
Chloride
intracellular
channel protein
2
Carbonic
anhydrase 1
Potassium
voltage-gated
channel
subfamily KQT
member 1
Potassium
voltage-gated
channel
subfamily E
member 2
Omeprazole
H
+
Active Metabolite of
Omeprazole
Histamine
Acetylcholine
Cl
-
Cl
-
HCO
3
-
H
2
O
CO
2
H
+
K
+
K
+
ATP
H
2
O
ADP
P
i
H
+
Zinc (II) ion
G-Protein
Signaling
Cascade
Parietal Cell
Stomach Lumen
Gastric Parietal Cell
Gastric Parietal Cell
Interstitial Fluid
Stomach Lumen
Capillary
From G cells in antrum
stomach
From enterochromaffin-like
(ECL) cells in the body and
fundus of the stomach
From intramural neurons in
the antrum, body, and fundus
of the stomach
From D cells in the antrum,
body, and fundus of the
stomach
Chloride ion from blood
circulation
Hydrogen carbonate
(bicarbonate) ion to blood
circulation
ATP4B
ATP4A
HRH2
Unknown
CCKBR
CHRM3
ATP4B
ATP4A
SST
SSTR2
CLIC2
CA1
KCNQ1
KCNE2
Omeprazole
Hydrogen
Active
Metabolite of
Omeprazole
Histamine
Acetylcholine
Chloride ion
Chloride ion
Hydrogen
carbonate
Water
Carbon dioxide
Hydrogen Ion
Potassium
Potassium
Adenosine
triphosphate
Water
Adenosine
diphosphate
Phosphate
Hydrogen Ion
G-Protein
Signaling
Cascade
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