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Pathway Description
Minocycline Action Pathway
Homo sapiens
Drug Action Pathway
Created: 2013-08-22
Last Updated: 2019-08-16
Minocycline is the most acitve tetracycline antibiotic that can prevent tRNA binding to 30S ribosomal of bacteria by blocking the 30S ribosomal subunit. Its lipid-solublable property allows it can pass lipid bilayers of membrane directly. Minocycline can also pass the membrane through porin channels in bacterial membrane. Due to blocking of 30S ribosomal subunit, activity of bacterial protein synthesis will be inihibited which lead to inhitation of further growth and colonization of bacteria.
References
Minocycline Pathway References
Minocin. (2009). e-CPS (online version of Compendium of Pharmaceuticals and Specialties). Retrieved July 17, 2009.
Song, K.S. Ribosomal protein synthesis inhibitors. In S. Offermanns, & W. Rosenthal (Eds.). Encyclopedic reference of molecular pharmacology. (2004) p. 827-833. Berlin, Germany: Springer.
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