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Estrogen
sulfotransferase
Estradiol
17-beta-
dehydrogenase 1
UDP-
glucuronosyltransferase
2B11
Cytochrome P450
19A1
Steroid
17-alpha-
hydroxylase/17,20
lyase
3-beta-HSD 1
Steroid
17-alpha-
hydroxylase/17,20
lyase
3-beta-HSD 1
Sulfotransferase
family
cytosolic 2B
member 1
Cytochrome P450
19A1
Testosterone
17-beta-
dehydrogenase 3
3-oxo-5-beta-
steroid
4-dehydrogenase
3-oxo-5-
alpha-steroid
4-dehydrogenase
1
UDP-
glucuronosyltransferase
2B17
Steryl-
sulfatase
17-Hydroxyprogesterone
17a-Hydroxypregnenolone
Estrone
Phosphoadenosine
phosphosulfate
Estrone sulfate
Adenosine 3',5'-diphosphate
19-Oxoandrost-4-ene-3,17-dione
Estradiol
NADP
NADPH
19-Oxotestosterone
19-Hydroxyandrost-4-ene-
3,17-dione
19-Hydroxytestosterone
Uridine diphosphate glucuronic
acid
17-β-Estradiol-3-glucuronide
Uridine 5'-diphosphate
Accumulation
Androstenedione
O
2
H
2
O
NAD
NADH
Accumulation
Dehydroepiandrosterone
NAD
NADH
Phosphoadenosine
phosphosulfate
Adenosine 3',5'-diphosphate
Dehydroepiandrosterone sulfate
Testosterone
O
2
H
2
O
NAD
NADH
H
+
5b-Dihydrotestosterone
Dihydrotestosterone
NADP
NADPH
H
+
Testosterone glucuronide
H
2
O
Sulfate
Heme
Heme
Heme
Reduced
flavoprotein
Oxidized
flavoprotein
Steroidogenesis
Calcium
Heme
ER Membrane
ER Membrane
Cytoplasm
ER Lumen
ER Lumen
Smooth Endoplasmic Reticulum
Intracellular Space
Extracellular Space