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High affinity
immunoglobulin
epsilon
receptor
subunit gamma
High affinity
immunoglobulin
epsilon
receptor
subunit gamma
Immunoglobulin
E
High affinity
immunoglobulin
epsilon
receptor
subunit alpha
High affinity
immunoglobulin
epsilon
receptor
subunit beta
High affinity
immunoglobulin
epsilon
receptor
subunit gamma
Immunoglobulin
E
High affinity
immunoglobulin
epsilon
receptor
subunit alpha
High affinity
immunoglobulin
epsilon
receptor
subunit beta
High affinity
immunoglobulin
epsilon
receptor
subunit gamma
Phosphatidylinositol
3,4,5-
trisphosphate
5-phosphatase 1
Protein kinase
C alpha type
RAC-alpha
serine/threonine-
protein kinase
Mitogen-
activated
protein kinase
8
Mitogen-
activated
protein kinase
14
Mitogen-
activated
protein kinase
1
Interleukin-4
Interleukin-13
Interleukin-3
Interleukin-5
Granulocyte-
macrophage
colony-
stimulating
factor
Tumor necrosis
factor
1-
phosphatidylinositol
4,5-
bisphosphate
phosphodiesterase
gamma-1
Dual
specificity
mitogen-
activated
protein kinase
kinase 1
Dual
specificity
mitogen-
activated
protein kinase
kinase 2
Tyrosine-
protein kinase
Lyn
Tyrosine-
protein kinase
BTK
Tyrosine-
protein kinase
Fyn
Tyrosine-
protein kinase
SYK
GRB2-
associated-
binding protein
2
Phosphatidylinositol-
4,5-
bisphosphate
3-kinase
catalytic
subunit alpha
isoform
Phosphatidylinositol
3-kinase
regulatory
subunit alpha
Lymphocyte
cytosolic
protein 2
Guanine
nucleotide
exchange factor
VAV3
Linker for
activation of
T-cells family
member 1
[Pyruvate
dehydrogenase
[lipoamide]]
kinase isozyme
1,
mitochondrial
Ras-related C3
botulinum toxin
substrate 1
Dual
specificity
mitogen-
activated
protein kinase
kinase 4
Dual
specificity
mitogen-
activated
protein kinase
kinase 7
Dual
specificity
mitogen-
activated
protein kinase
kinase 3
Dual
specificity
mitogen-
activated
protein kinase
kinase 6
Growth factor
receptor-bound
protein 2
Son of
sevenless
homolog 1
GTPase NRas
GTPase KRas
GTPase HRas
RAF
proto-oncogene
serine/threonine-
protein kinase
Cytosolic
phospholipase
A2
Phosphatidylinositol-3,4,5-
trisphosphate
Histamine
Heparin
Arachidonic acid
Prostaglandin
D2
Leukotriene E4
Leukotriene D4
Leukotriene C4
Phosphatidylinositol-3,4,5-
trisphosphate
Inositol 1,4,5-trisphosphate
Mono- and diglycerides
Ca
+
Calcium
Magnesium
Magnesium
Magnesium
Calcium
Zinc
Manganese
Magnesium
Zinc
Calcium
Degranulation
Cytokine gene
transcription
Generation of
eicosanoids
Phosphatidylinositol
signaling
system
MAPK signaling
pathway
Arachidonic
Acid Metabolism
Mast Cell
Antigen
Antigen
Indirect activation
Indirect activation
Indirect activation
Indirect activation
Indirect activation
Release from granules
Indirect activation
Indirect activation
Secretion
Indirect activation
Extracellular Space
Unknown
Unknown
Unknown
FCER1A
Unknown
Unknown
Unknown
FCER1A
Unknown
Unknown
INPP5D
PRKCA
AKT1
MAPK8
MAPK14
MAPK1
Unknown
Unknown
IL3
IL5
Unknown
TNF
PLCG1
MAP2K1
MAP2K2
Unknown
BTK
FYN
SYK
GAB2
PIK3CA
PIK3R1
Unknown
VAV3
LAT
PDK1
RAC1
MAP2K4
MAP2K7
MAP2K3
MAP2K6
GRB2
SOS1
NRAS
KRAS
HRAS
RAF1
PLA2G4A
Phosphatidylinositol-
3,4,5-
trisphosphate
Histamine
Heparin
Arachidonic
acid
Prostaglandin
D2
Leukotriene E4
Leukotriene D4
Leukotriene C4
Phosphatidylinositol-
3,4,5-
trisphosphate
Inositol 1,4,5-
trisphosphate
Mono- and
diglycerides
Calcium
Degranulation
Cytokine gene
transcription
Generation of
eicosanoids
Phosphatidylinositol
signaling
system
MAPK signaling
pathway
Arachidonic
Acid Metabolism
FCER1A
FCER1A
INPP5D
PRKCA
AKT1
MAPK8
MAPK14
MAPK1
IL3
IL5
TNF
PLCG1
MAP2K1
MAP2K2
BTK
FYN
SYK
GAB2
PIK3CA
PIK3R1
VAV3
LAT
PDK1
RAC1
MAP2K4
MAP2K7
MAP2K3
MAP2K6
GRB2
SOS1
NRAS
KRAS
HRAS
RAF1
PLA2G4A
P345T
Hsm
Heparin
20:4
ProglD2
LTE4
LTD4
LTC4
P345T
Inotp
MAD
Ca
+
Ca2+
Mg2+
Mg2+
Mg2+
Ca2+
Zinc
Mn2+
Mg2+
Zinc
Ca2+
Degra
Cy ge t
Ge of e
Ph si s
MA si p
PW000044
Mast Cell
Antigen
Antigen
Indirect activation
Indirect activation
Indirect activation
Indirect activation
Indirect activation
Release from granules
Indirect activation
Indirect activation
Secretion
Indirect activation
Extracellular Space