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Ca
+
Na
+
Ca
+
Ca
+
Na
+
K
+
K
+
Sodium-
dependent
serotonin
transporter
Cytochrome P450
2D6
Cytochrome P450
3A5
Cytochrome P450
3A4
Cytochrome P450
2C9
Cytochrome P450
2C19
Cytochrome P450
2D6
Alpha-1A
adrenergic
receptor
5-
hydroxytryptamine
receptor 1A
D(1A) dopamine
receptor
Beta-endorphin
Mu-type opioid
receptor
Neuronal
acetylcholine
receptor
subunit beta-2
Neuronal
acetylcholine
receptor
subunit beta-2
Neuronal
acetylcholine
receptor
subunit beta-2
Neuronal
acetylcholine
receptor
subunit alpha-4
Voltage-
dependent
P/Q-type
calcium channel
subunit
alpha-1A
Voltage-
dependent
L-type calcium
channel subunit
beta-1
Voltage-
dependent
calcium channel
subunit
alpha-2/delta-2
Potassium
voltage-gated
channel
subfamily D
member 2
Kv channel-
interacting
protein 2
Beta-endorphin
Glutamate
[NMDA] receptor
subunit zeta-1
Glutamate
[NMDA] receptor
subunit
epsilon-1
Glutamate
[NMDA] receptor
subunit 3A
Sodium-
dependent
noradrenaline
transporter
Sodium-
dependent
serotonin
transporter
Sodium-
dependent
dopamine
transporter
Pro-
opiomelanocortin
Neuroendocrine
convertase 2
Sodium/potassium-
transporting
ATPase subunit
alpha-1
Fluoxetine
Norfluoxetine
Fluoxetine
Fluoxetine glucuronide
Norfluoxetine glucuronide
O
2
NADH
H
2
O
Formaldehyde
NAD
Heme
Heme
Heme
Heme
Heme
Heme
Norepinephrine
Serotonin
Dopamine
Ca
+
Na
+
K
+
Ca
+
Ca
+
Norepinephrine
Serotonin
Na
+
Na
+
Na
+
Na
+
Dopamine
Na
+
Na
+
ATP
H
2
O
Na
+
K
+
ADP
P
i
Na
+
K
+
Sodium channel
protein type 10
subunit alpha
Neuronal
acetylcholine
receptor
subunit alpha-4
Sodium channel
subunit beta-1
Sodium/potassium-
transporting
ATPase subunit
alpha-3
Sodium/potassium-
transporting
ATPase subunit
beta-2
Sodium/potassium-
transporting
ATPase subunit
alpha-2
Sodium/potassium-
transporting
ATPase subunit
alpha-4
Sodium/potassium-
transporting
ATPase subunit
beta-1
Sodium/potassium-
transporting
ATPase subunit
gamma
Neuronal
acetylcholine
receptor
subunit alpha-4
Sodium/potassium-
transporting
ATPase subunit
beta-3
ATPase,
(Na+)/K+
transporting,
beta 4
polypeptide
Axon Terminal
Synaptic Vesicle
Presynaptic Neuron
Postsynaptic Neuron
Synaptic Cleft
Neuron
Neuron Axon
Action Potential
Membrane Potential (mV)
Resting Potential
-70
Time
+40
0
Depolarization
Peak Action Potential
Repolarization
Hyperpolarization
Chloroplast
Vacuole
Calcium
Sodium
Calcium
Calcium
Sodium
Potassium
Potassium
SLC6A4
CYP2D6
CYP3A5
CYP3A4
CYP2C9
CYP2C19
CYP2D6
ADRA1A
HTR1A
DRD1
Unknown
OPRM1
Unknown
Unknown
Unknown
Unknown
CACNA1A
CACNB1
CACNA2D2
KCND2
KCNIP2
Unknown
GRIN1
GRIN2A
GRIN3A
SLC6A2
SLC6A4
SLC6A3
Unknown
Unknown
ATP1A1
Fluoxetine
Norfluoxetine
Fluoxetine
Fluoxetine
glucuronide
Norfluoxetine
glucuronide
Oxygen
NADH
Water
Formaldehyde
NAD
Norepinephrine
Serotonin
Dopamine
Calcium
Sodium
Potassium
Calcium
Calcium
Norepinephrine
Serotonin
Sodium
Sodium
Sodium
Sodium
Dopamine
Sodium
Sodium
Adenosine
triphosphate
Water
Sodium
Potassium
Adenosine
diphosphate
Phosphate
Sodium
Potassium
SCN10A
Unknown
SCN1B
ATP1A3
ATP1B2
ATP1A2
ATP1A4
ATP1B1
FXYD2
Unknown
ATP1B3
Unknown
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