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DNA
topoisomerase 1
Multidrug
resistance
protein 1
Solute carrier
organic anion
transporter
family member
1B1
Multidrug
resistance-
associated
protein 1
Multidrug
resistance
protein 1
Canalicular
multispecific
organic anion
transporter 1
Canalicular
multispecific
organic anion
transporter 1
ATP-binding
cassette
sub-family G
member 2
Multidrug
resistance
protein 1
Canalicular
multispecific
organic anion
transporter 1
Cytochrome P450
3A4
Cytochrome P450
3A5
Cytochrome P450
3A4
Liver
carboxylesterase
1
Cocaine
esterase
UDP-
glucuronosyltransferase
1-10
UDP-
glucuronosyltransferase
1-1
UDP-
glucuronosyltransferase
1-9
UDP-
glucuronosyltransferase
1-1
Liver
carboxylesterase
1
Cocaine
esterase
Liver
carboxylesterase
1
Cocaine
esterase
Cholinesterase
Liver
carboxylesterase
1
Cocaine
esterase
Irinotecan
SN-38
Irinotecan
SN-38
SN-38 Glucuronide
SN-38 Glucuronide
NPC
APC
H
2
O
Uridine
diphosphate
glucuronic acid
Uridine
5'-diphosphate
Uridine
diphosphate
glucuronic acid
Uridine
5'-diphosphate
H
2
O
H
2
O
Irinotecan
H
2
O
SN-38
H
2
O
ATP
P
i
ADP
H
2
O
ATP
P
i
ADP
H
2
O
ATP
P
i
ADP
H
2
O
ATP
P
i
ADP
H
2
O
ATP
P
i
ADP
H
2
O
ATP
P
i
ADP
H
2
O
ATP
P
i
ADP
H
2
O
ATP
P
i
ADP
Heme
Heme
Heme
Carboxylate
Carboxylate
Carboxylate
Carboxylate
Nucleus
Bacterial Glucuronidation
Endoplasmic Reticulum
Endoplasmic Reticulum
Unknown
ABCB1
SLCO1B1
ABCC1
ABCB1
ABCC2
ABCC2
ABCG2
ABCB1
ABCC2
CYP3A4
CYP3A5
CYP3A4
CES1
CES2
UGT1A10
UGT1A1
UGT1A9
UGT1A1
CES1
CES2
CES1
CES2
BCHE
CES1
CES2
Irinotecan
SN-38
Irinotecan
SN-38
SN-38
Glucuronide
SN-38
Glucuronide
NPC
APC
Water
Uridine
diphosphate
glucuronic acid
Uridine
5'-diphosphate
Uridine
diphosphate
glucuronic acid
Uridine
5'-diphosphate
Water
Water
Irinotecan
Water
SN-38
Water
Adenosine
triphosphate
Phosphate
Adenosine
diphosphate
Water
Adenosine
triphosphate
Phosphate
Adenosine
diphosphate
Water
Adenosine
triphosphate
Phosphate
Adenosine
diphosphate
Water
Adenosine
triphosphate
Phosphate
Adenosine
diphosphate
Water
Adenosine
triphosphate
Phosphate
Adenosine
diphosphate
Water
Adenosine
triphosphate
Phosphate
Adenosine
diphosphate
Water
Adenosine
triphosphate
Phosphate
Adenosine
diphosphate
Water
Adenosine
triphosphate
Phosphate
Adenosine
diphosphate
Carboxylate
Carboxylate
Carboxylate
Carboxylate