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DNA
topoisomerase
2-alpha
DNA
topoisomerase
2-beta
Multidrug
resistance
protein 1
Canalicular
multispecific
organic anion
transporter 2
Prostaglandin
G/H synthase 1
Prostaglandin
G/H synthase 2
UDP-
glucuronosyltransferase
1-1
Cytochrome P450
3A4
Cytochrome P450
3A5
Myeloperoxidase
Etoposide
Etoposide catechol
Etoposide ortho-quinone
Etoposide
Uridine
diphosphate
glucuronic acid
Etoposide glucuronide
Uridine
5'-diphosphate
O
2
NADH
Etoposide catechol
H
2
O
Formaldehyde
NAD
NAD
Etoposide ortho-quinone
NADH
H
2
O
ATP
P
i
ADP
H
2
O
ATP
P
i
ADP
Magnesium
Magnesium
Heme
Heme
Heme
Heme
Calcium
Heme
Oxidative DNA
Damage (Cell
Death)
Lysosome
Nucleus
Endoplasmic Reticulum
Endoplasmic Reticulum
TOP2A
TOP2B
ABCB1
ABCC3
PTGS1
PTGS2
UGT1A1
CYP3A4
CYP3A5
MPO
Etoposide
Etoposide
catechol
Etoposide
ortho-quinone
Etoposide
Uridine
diphosphate
glucuronic acid
Etoposide
glucuronide
Uridine
5'-diphosphate
Oxygen
NADH
Etoposide
catechol
Water
Formaldehyde
NAD
NAD
Etoposide
ortho-quinone
NADH
Water
Adenosine
triphosphate
Phosphate
Adenosine
diphosphate
Water
Adenosine
triphosphate
Phosphate
Adenosine
diphosphate
Oxidative DNA
Damage (Cell
Death)