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Acyl-CoA
synthetase
short-chain
family member 3,
mitochondrial
Enoyl-CoA
hydratase,
mitochondrial
3-hydroxyacyl-CoA
dehydrogenase
type-2
Hydroxyacyl-
coenzyme A
dehydrogenase,
mitochondrial
Acetyl-CoA
acetyltransferase,
mitochondrial
Enoyl-CoA
hydratase,
mitochondrial
3-hydroxyacyl-CoA
dehydrogenase
type-2
Hydroxyacyl-
coenzyme A
dehydrogenase,
mitochondrial
3-ketoacyl-CoA
thiolase,
mitochondrial
Acetyl-CoA
acetyltransferase,
mitochondrial
3-ketoacyl-CoA
thiolase,
mitochondrial
Short-chain
specific acyl-CoA
dehydrogenase,
mitochondrial
Long-chain
specific acyl-CoA
dehydrogenase,
mitochondrial
Acetyl-CoA
Acetyl-CoA
Caproic acid
Hexanoyl-CoA
Caproic acid
ATP
CoA
AMP
PP
i
3-
Hydroxyhexanoyl-
CoA
(2E)-Hexenoyl-CoA
H
2
O
NAD
3-oxohexanoyl-CoA
NADH
H
+
NAD
NADH
H
+
Butyryl-CoA
CoA
3-
Hydroxybutyryl-
CoA
Crotonoyl-CoA
H
2
O
NAD
Acetoacetyl-CoA
NADH
H
+
NAD
NADH
H
+
CoA
CoA
CoA
electron-
transfer
flavoprotein
Reduced
electron-
transfer
flavoprotein
electron-
transfer
flavoprotein
Reduced
electron-
transfer
flavoprotein
Citric Acid
Cycle
Citric Acid
Cycle
Fatty Acid
Biosynthesis
Fatty Acid
Elongation in
Mitochondria
Mitochondrial
Beta-Oxidation
of Medium Chain
Saturated Fatty
Acids
FAD
FAD
Mitochondrial Outer Membrane
Mitochondrial Inner Membrane
Mitochondrial Matrix
Cytosol
Mitochondria
ACSS3
ECHS1
HSD17B10
HADH
ACAT1
ECHS1
HSD17B10
HADH
ACAA2
ACAT1
ACAA2
ACADS
ACADL
Acetyl-CoA
Acetyl-CoA
Caproic acid
Hexanoyl-CoA
Caproic acid
Adenosine
triphosphate
Coenzyme A
Adenosine
monophosphate
Pyrophosphate
3-
Hydroxyhexanoyl-
CoA
(2E)-Hexenoyl-CoA
Water
NAD
3-oxohexanoyl-CoA
NADH
Hydrogen Ion
NAD
NADH
Hydrogen Ion
Butyryl-CoA
Coenzyme A
3-
Hydroxybutyryl-
CoA
Crotonoyl-CoA
Water
NAD
Acetoacetyl-CoA
NADH
Hydrogen Ion
NAD
NADH
Hydrogen Ion
Coenzyme A
Coenzyme A
Coenzyme A
electron-transfer
flavoprotein
Reduced
electron-transfer
flavoprotein
electron-transfer
flavoprotein
Reduced
electron-transfer
flavoprotein
Citric Acid Cycle
Citric Acid Cycle
Fatty Acid
Biosynthesis
Fatty Acid
Elongation in
Mitochondria
Mitochondrial
Beta-Oxidation of
Medium Chain
Saturated Fatty
Acids