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Aldo-keto
reductase
family 1 member
C4
3-oxo-5-beta-
steroid
4-dehydrogenase
Cytochrome P450
11B2,
mitochondrial
Cytochrome P450
11B1,
mitochondrial
Aldo-keto
reductase
family 1 member
C4
Corticosteroid
11-beta-
dehydrogenase
isozyme 1
Aldo-keto
reductase
family 1 member
C4
Steroid
21-hydroxylase
Steroid
17-alpha-
hydroxylase/17,20
lyase
Steroid
21-hydroxylase
Cytochrome P450
11B1,
mitochondrial
3-beta-HSD 1
Steroid
21-hydroxylase
3-beta-HSD 1
Cytochrome P450
11B2,
mitochondrial
Steroid
21-hydroxylase
Cytochrome P450
11B1,
mitochondrial
Cytochrome P450
11B1,
mitochondrial
Steroid
17-alpha-
hydroxylase/17,20
lyase
Steroid
21-hydroxylase
3-beta-HSD 1
3-beta-HSD 1
Steroid
17-alpha-
hydroxylase/17,20
lyase
Steroid
21-hydroxylase
Cholesterol
side-chain
cleavage
enzyme,
mitochondrial
Cholesterol
side-chain
cleavage
enzyme,
mitochondrial
Cholesterol
side-chain
cleavage
enzyme,
mitochondrial
Cholesterol
side-chain
cleavage
enzyme,
mitochondrial
Cholesterol
side-chain
cleavage
enzyme,
mitochondrial
Cholesterol
side-chain
cleavage
enzyme,
mitochondrial
Steroid
17-alpha-
hydroxylase/17,20
lyase
3-oxo-5-beta-
steroid
4-dehydrogenase
Aldo-keto
reductase
family 1 member
C4
3-oxo-5-beta-
steroid
4-dehydrogenase
Aldo-keto
reductase
family 1 member
C4
Cytochrome P450
11B1,
mitochondrial
3-oxo-5-beta-
steroid
4-dehydrogenase
Aldo-keto
reductase
family 1 member
C4
Corticosteroid
11-beta-
dehydrogenase
isozyme 2
Corticosteroid
11-beta-
dehydrogenase
isozyme 2
3 beta-
hydroxysteroid
dehydrogenase/Delta
5-->4-isomerase
type 2
Cholesterol
Accumulation
Progesterone
Accumulation
Progesterone
11b,21-Dihydroxy-3,20-oxo-
5b-pregnan-18-al
NADPH
3a,11b,21-Trihydroxy-20-oxo-
5b-pregnan-18-al
NADP
NADP
Aldosterone
NADPH
18-Hydroxycorticosterone
O
2
H
2
O
Corticosterone
O
2
H
2
O
11b,21-Dihydroxy-5b-
pregnane-3,20-dione
Tetrahydrocorticosterone
NADP
NADPH
Accumulation
11-Dehydrocorticosterone
21-Hydroxy-5b-pregnane-
3,11,20-trione
NADP
3a,21-Dihydroxy-5b-pregnane-
11,20-dione
NADPH
NADP
NADPH
11b-Hydroxyprogesterone
21-Deoxycortisol
Cortisol
Accumulation
Deoxycorticosterone
21-Hydroxypregnenolone
NAD
NADH
Accumulation
Pregnenolone
NAD
NADH
17-Hydroxyprogesterone
Cortexolone
17a-Hydroxypregnenolone
NAD
NADH
NADH
17α,21-Dihydroxypregnenolone
NAD
20a,22b-Dihydroxycholesterol
4-Methylpentanal
17a,20a-Dihydroxycholesterol
22b-Hydroxycholesterol
20α-Hydroxycholesterol
17a,21-Dihydroxy-5b-
pregnane-3,11,20-trione
NADP