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Pathway Description
Etoposide Metabolism Pathway
Homo sapiens
Drug Metabolism Pathway
Created: 2013-09-11
Last Updated: 2019-10-29
Etoposide is a medication commonly sold as Vepesid, or Etopophos. It is a type of chemotherapy. It is used to treat many types of cancers, including nonlymphocytic leukemia and testicular cancer. Etoposide is semisynthetic and a derivative of the podophyllotoxins which is an epipodophyllotoxin. This substance is found in the root of the American Mayapple plant. The way this substance works is by inhibiting topoisomerase II, which inhibits DNA synthesis. This breaks the catalytic cycle of topoisomerase II, and after a while overwhelms the cell. This can cause a death pathway, killing the cancer cell. Etoposide is administered by a doctor, through intravenous infusion.
References
Etoposide Pathway References
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Pubmed: 2845399
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Pubmed: 8383537
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Pubmed: 2556712
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Pubmed: 10827079
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Pubmed: 15164053
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