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Cytochrome P450
2C8
Cytochrome P450
2C9
Cytochrome P450
2B6
Cytochrome P450
3A4
Cytochrome P450
3A5
Cytochrome P450
2A6
Retinal
dehydrogenase 1
Aldehyde
dehydrogenase,
dimeric
NADP-preferring
Retinal
dehydrogenase 1
Cytochrome P450
3A4
Cytochrome P450
3A5
Cytochrome P450
2B6
Aldoifosfamide
4-Hydroxyifosfamide
Aldoifosfamide
Acrolein
Alcoifosfamide
Isophosphamide mustard
Ifosforamide Aziridinium
Cl
-
4-Ketoifosfamide
Ifosfamide
O
2
NADPH
H
+
H
2
O
NADP
NAD
H
2
O
Acrylic acid
NADH
H
+
H
2
O
NAD
Carboxyifosfamide
NADH
H
+
O
2
H
2
O
Chloroacetaldehyde
3-Dechloroethylifosfamide
2-Dechloroethylifosfamide
H
2
O
2
Heme
Heme
Heme
Heme
Heme
Heme
Heme
Heme
Heme
Endoplasmic Reticulum
Membrane
Endoplasmic Reticulum
CYP2C8
CYP2C9
CYP2B6
CYP3A4
CYP3A5
CYP2A6
ALDH1A1
ALDH3A1
ALDH1A1
CYP3A4
CYP3A5
CYP2B6
Aldoifosfamide
4-
Hydroxyifosfamide
Aldoifosfamide
Acrolein
Alcoifosfamide
Isophosphamide
mustard
Ifosforamide
Aziridinium
Chloride ion
4-
Ketoifosfamide
Ifosfamide
Oxygen
NADPH
Hydrogen Ion
Water
NADP
NAD
Water
Acrylic acid
NADH
Hydrogen Ion
Water
NAD
Carboxyifosfamide
NADH
Hydrogen Ion
Oxygen
Water
Chloroacetaldehyde
3-
Dechloroethylifosfamide
2-
Dechloroethylifosfamide
Hydrogen
peroxide