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Mu-type opioid
receptor
UDP-
glucuronosyltransferase
2B7
Cytochrome P450
3A4
Cytochrome P450
2D6
Morphine
Morphine
Codeine
Uridine
diphosphate
glucuronic acid
Codeine-6-glucuronide
Uridine
5'-diphosphate
O
2
NADH
Norcodeine
H
2
O
Formaldehyde
NAD
O
2
NADH
H
2
O
Formaldehyde
NAD
Heme
Heme
Morphine
Pathway
Dendrite
OPRM1
UGT2B7
CYP3A4
CYP2D6
Morphine
Morphine
Codeine
Uridine
diphosphate
glucuronic acid
Codeine-6-
glucuronide
Uridine
5'-diphosphate
Oxygen
NADH
Norcodeine
Water
Formaldehyde
NAD
Oxygen
NADH
Water
Formaldehyde
NAD
Morphine
Pathway
OPRM1
UGT2B7
CYP3A4
CYP2D6
Morfin
Morfin
Codeine
UDPGlcA
Code6gl
UDP
O
2
NADH
Norcode
H
2
O
Formol
NAD
O
2
NADH
H
2
O
Formol
NAD
Heme
Heme
PW000412
Dendrite