SMPDB

Pathway Description

Prednisone Metabolism Pathway

Homo sapiens

Drug Metabolism Pathway

Created: 2013-09-11

Last Updated: 2019-10-29

Prednisone is a medication that is used to suppress the immune system. It works by interrupting cytokine pathways type 1 and type 2. It is administered orally, through tablet, or solution (concentrated or non-concentrated). Prednisone is a glucocorticoid, and as well as being used for immune system suppression, it is used for its anti inflammatory properties. It exerts these properties by binding to glucocorticoid receptors in the cell, which inhibits inflammatory cells. This prevents inflammatory mediators from being expressed.

References

Prednisone Pathway References

Barnes PJ, Adcock IM: Glucocorticoid resistance in inflammatory diseases. Lancet. 2009 May 30;373(9678):1905-17. doi: 10.1016/S0140-6736(09)60326-3.

Pubmed: 19482216

Frey BM, Frey FJ: Clinical pharmacokinetics of prednisone and prednisolone. Clin Pharmacokinet. 1990 Aug;19(2):126-46. doi: 10.2165/00003088-199019020-00003.

Pubmed: 2199128

Pujolsa L, Mullol J, Picado C: Glucocorticoid receptor in human respiratory epithelial cells. Neuroimmunomodulation. 2009;16(5):290-9. doi: 10.1159/000216187. Epub 2009 Jun 29.

Pubmed: 19571590

Hsieh KP, Lin YY, Cheng CL, Lai ML, Lin MS, Siest JP, Huang JD: Novel mutations of CYP3A4 in Chinese. Drug Metab Dispos. 2001 Mar;29(3):268-73.

Pubmed: 11181494

Molowa DT, Schuetz EG, Wrighton SA, Watkins PB, Kremers P, Mendez-Picon G, Parker GA, Guzelian PS: Complete cDNA sequence of a cytochrome P-450 inducible by glucocorticoids in human liver. Proc Natl Acad Sci U S A. 1986 Jul;83(14):5311-5. doi: 10.1073/pnas.83.14.5311.

Pubmed: 3460094

Gonzalez FJ, Schmid BJ, Umeno M, Mcbride OW, Hardwick JP, Meyer UA, Gelboin HV, Idle JR: Human P450PCN1: sequence, chromosome localization, and direct evidence through cDNA expression that P450PCN1 is nifedipine oxidase. DNA. 1988 Mar;7(2):79-86. doi: 10.1089/dna.1988.7.79.

Pubmed: 3267210

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	Heme
	Hydrogen Ion
	Prednisolone
	Prednisone

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Cytochrome P450 3A4

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