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Cytochrome P450
2D6
Cytochrome P450
2D6
Cytochrome P450
1A2
Cytochrome P450
2C19
Cytochrome P450
3A4
Cytochrome P450
1A2
2-hydroxydesmethyl
clomipramine
2-hydroxydesmethyl
clomipramine glucuronide
2-hydroxyclomipramine
glucuronide
Clomipramine
O
2
NADPH
H
+
2-Hydroxyclomipramine
H
2
O
NADP
Desmethylclomipramine
O
2
NADPH
H
+
H
2
O
NADP
O
2
NADH
Formaldehyde
NAD
H
2
O
O
2
NADH
didesmethylclomipramine
Formaldehyde
NAD
H
2
O
Heme
Heme
Heme
Heme
Heme
Heme
Endoplasmic Reticulum
CYP2D6
CYP2D6
CYP1A2
CYP2C19
CYP3A4
CYP1A2
2-
hydroxydesmethyl
clomipramine
2-
hydroxydesmethyl
clomipramine
glucuronide
2-
hydroxyclomipramine
glucuronide
Clomipramine
Oxygen
NADPH
Hydrogen
2-
Hydroxyclomipramine
Water
NADP
Desmethylclomipramine
Oxygen
NADPH
Hydrogen Ion
Water
NADP
Oxygen
NADH
Formaldehyde
NAD
Water
Oxygen
NADH
didesmethylclomipramine
Formaldehyde
NAD
Water
CYP2D6
CYP2D6
CYP1A2
CYP2C19
CYP3A4
CYP1A2
2hdc
2hdcg
2hcg
Clomipr
O
2
NADPH
H
+
2HCP
H
2
O
NADP
Desmtcp
O
2
NADPH
H
+
H
2
O