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Cytochrome P450
2E1
Cytochrome P450
1A2
Cytochrome P450
2D6
Cytochrome P450
3A4
Cytochrome P450
2A6
UDP-
glucuronosyltransferase
1-9
UDP-
glucuronosyltransferase
2B15
UDP-
glucuronosyltransferase
1-1
UDP-
glucuronosyltransferase
1-6
Glutathione
S-transferase P
Glutathione
S-transferase
theta-1
Sulfotransferase
1A1
Estrogen
sulfotransferase
Bile salt
sulfotransferase
Sulfotransferase
1A3/1A4
Multidrug
resistance-
associated
protein 1
Multidrug
resistance-
associated
protein 4
Multidrug
resistance-
associated
protein 5
ATP-binding
cassette
sub-family G
member 2
Multidrug
resistance
protein 1
Acetaminophen
NAD
NAPQI
NADH
Uridine
diphosphate
glucuronic acid
Acetaminophen glucuronide
Uridine
5'-diphosphate
Glutathione
Acetaminophen cystein
H
2
O
Phosphoadenosine
phosphosulfate
Paracetamol sulfate
Adenosine
3',5'-
diphosphate
H
2
O
ATP
Acetaminophen cystein
P
i
ADP
H
2
O
ATP
P
i
ADP
H
2
O
ATP
P
i
ADP
H
2
O
ATP
Paracetamol sulfate
P
i
ADP
H
2
O
ATP
P
i
ADP
Acetaminophen glucuronide
Heme
Heme
Heme
Heme
Heme
Endoplasmic Reticulum
CYP2E1
CYP1A2
CYP2D6
CYP3A4
CYP2A6
UGT1A9
UGT2B15
UGT1A1
UGT1A6
GSTP1
GSTT1
SULT1A1
SULT1E1
SULT2A1
SULT1A3
ABCC1
ABCC4
ABCC5
ABCG2
ABCB1
Acetaminophen
NAD
NAPQI
NADH
Uridine
diphosphate
glucuronic acid
Acetaminophen
glucuronide
Uridine
5'-diphosphate
Glutathione
Acetaminophen
cystein
Water
Phosphoadenosine
phosphosulfate
Paracetamol
sulfate
Adenosine
3',5'-
diphosphate
Water
Adenosine
triphosphate
Acetaminophen
cystein
Phosphate
Adenosine
diphosphate
Water
Adenosine
triphosphate
Phosphate
Adenosine
diphosphate
Water
Adenosine
triphosphate
Phosphate
Adenosine
diphosphate
Water
Adenosine
triphosphate
Paracetamol
sulfate
Phosphate
Adenosine
diphosphate
Water
Adenosine
triphosphate
Phosphate
Adenosine
diphosphate
Acetaminophen
glucuronide