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Multidrug
resistance-
associated
protein 7
Multidrug
resistance-
associated
protein 7
Multidrug
resistance-
associated
protein 7
Multidrug
resistance-
associated
protein 7
Cytochrome P450
2B6
Cytochrome P450
3A4
Cytochrome P450
2B6
Cytochrome P450
2D6
Cytochrome P450
3A4
Cytochrome P450
3A5
Cytochrome P450
3A4
Cytochrome P450
3A5
Cytochrome P450
2C9
Cytochrome P450
2D6
UDP-
glucuronosyltransferase
1-10
UDP-
glucuronosyltransferase
1-10
UDP-
glucuronosyltransferase
1-10
UDP-
glucuronosyltransferase
1-10
Retinal
dehydrogenase 1
3-Hydroxynevirapine
glucuronide
8-Hydroxynevirapine
glucuronide
2-Hydroxynevirapine
glucuronide
12-Hydroxynevirapine
glucuronide
Nevirapine
O
2
NADPH
H
+
3-Hydroxynevirapine
H
2
O
NADP
O
2
NADPH
H
+
8-Hydroxynevirapine
H
2
O
NADP
O
2
NADPH
H
+
2-Hydroxynevirapine
H
2
O
NADP
O
2
NADPH
H
+
12-Hydroxynevirapine
H
2
O
NADP
Uridine
diphosphate
glucuronic acid
3-Hydroxynevirapine
glucuronide
Uridine
5'-diphosphate
Uridine
diphosphate
glucuronic acid
8-Hydroxynevirapine
glucuronide
Uridine
5'-diphosphate
Uridine
diphosphate
glucuronic acid
2-Hydroxynevirapine
glucuronide
Uridine
5'-diphosphate
Uridine
diphosphate
glucuronic acid
12-Hydroxynevirapine
glucuronide
Uridine
5'-diphosphate
H
2
O
O
2
4-Carboxynevirapine
H
2
O
2
ATP
H
2
O
ADP
P
i
ATP
H
2
O
ADP
P
i
ATP
H
2
O
ADP
P
i
ATP
H
2
O
ADP
P
i
Heme
Heme
Heme
Heme
Heme
Heme
Heme
Heme
Heme
Heme
HIV Reverse
Transcriptase
Endoplasmic Reticulum
ABCC10
ABCC10
ABCC10
ABCC10
CYP2B6
CYP3A4
CYP2B6
CYP2D6
CYP3A4
CYP3A5
CYP3A4
CYP3A5
CYP2C9
CYP2D6
UGT1A10
UGT1A10
UGT1A10
UGT1A10
ALDH1A1
3-
Hydroxynevirapine
glucuronide
8-
Hydroxynevirapine
glucuronide
2-
Hydroxynevirapine
glucuronide
12-
Hydroxynevirapine
glucuronide
Nevirapine
Oxygen
NADPH
Hydrogen Ion
3-
Hydroxynevirapine
Water
NADP
Oxygen
NADPH
Hydrogen Ion
8-
Hydroxynevirapine
Water
NADP
Oxygen
NADPH
Hydrogen Ion
2-
Hydroxynevirapine
Water
NADP
Oxygen
NADPH
Hydrogen Ion
12-
Hydroxynevirapine
Water
NADP
Uridine
diphosphate
glucuronic acid
3-
Hydroxynevirapine
glucuronide
Uridine
5'-diphosphate
Uridine
diphosphate
glucuronic acid
8-
Hydroxynevirapine
glucuronide
Uridine
5'-diphosphate
Uridine
diphosphate
glucuronic acid
2-
Hydroxynevirapine
glucuronide
Uridine
5'-diphosphate
Uridine
diphosphate
glucuronic acid
12-
Hydroxynevirapine
glucuronide
Uridine
5'-diphosphate
Water
Oxygen
4-
Carboxynevirapine
Hydrogen
peroxide
Adenosine
triphosphate
Water
Adenosine
diphosphate
Phosphate
Adenosine
triphosphate
Water
Adenosine
diphosphate
Phosphate
Adenosine
triphosphate
Water
Adenosine
diphosphate
Phosphate