Loading Pathway...
Error: Pathway image not found.
Hide
Pathway Description
Chloramphenicol Action Pathway
Homo sapiens
Drug Action Pathway
Created: 2014-06-23
Last Updated: 2019-08-16
Chloramphenicol, trade names Pentamycetin and Chloromycetin, is a broad spectrum antibiotic originally derived from Streptomyces venezuelae. It inhibits protein synthesis by binding the 50S ribosomal subunit to prevent bacterial growth. Bacterial resistance has occurred through decreased uptake or permeability, ribosomal mutation and inactivation by acetylation. Adverse side effects such as aplastic anemia, bone-marrow suppression or Gray syndrome in neonates and infants have resulted in limited use. However, due to ampicillin-resistance bacterial meningitis there has been a renewed interest in the drug.
References
Chloramphenicol Pathway References
Nitzan O, Kennes Y, Colodner R, Saliba W, EdelsteinI H, Raz R, Chazan B: Chloramphenicol use and susceptibility patterns in Israel: a national survey. Isr Med Assoc J. 2015 Jan;17(1):27-31.
Pubmed: 25739173
Schwarz S, Kehrenberg C, Doublet B, Cloeckaert A: Molecular basis of bacterial resistance to chloramphenicol and florfenicol. FEMS Microbiol Rev. 2004 Nov;28(5):519-42. doi: 10.1016/j.femsre.2004.04.001.
Pubmed: 15539072
Ambrose PJ: Clinical pharmacokinetics of chloramphenicol and chloramphenicol succinate. Clin Pharmacokinet. 1984 May-Jun;9(3):222-38. doi: 10.2165/00003088-198409030-00004.
Pubmed: 6375931
Highlighted elements will appear in red.
Highlight Compounds
Highlight Proteins
No Proteins Present
Enter relative concentration values (without units). Elements will be highlighted in a color gradient where red = lowest concentration and green = highest concentration. For the best results, view the pathway in Black and White.
Visualize Compound Data
Visualize Protein Data
No Proteins Present
Settings