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Pathway Description
Abacavir Action Pathway
Homo sapiens
Drug Action Pathway
Created: 2014-06-23
Last Updated: 2019-08-16
Abacavir (also known as Ziagen or Epzicom) is an antiviral agent that is used for treating HIV/AID. Cellular enzyme converts abacavir to its activate metabolite, carbovir triphosphate, for inhibiting HIV-1 reverse transcriptase (RT) by competing with dGTP, which is the natural substrate of RT. Without HIV-1 reverse transcriptase, complementary DNA (cDNA) could not be generated; therefore, viral DNA couldn't be completed.
References
Abacavir Pathway References
Falcinelli E, Francisci D, Belfiori B, Petito E, Guglielmini G, Malincarne L, Mezzasoma A, Sebastiano M, Conti V, Giannini S, Bonora S, Baldelli F, Gresele P: In vivo platelet activation and platelet hyperreactivity in abacavir-treated HIV-infected patients. Thromb Haemost. 2013 Aug;110(2):349-57. doi: 10.1160/TH12-07-0504. Epub 2013 May 23.
Pubmed: 23703656
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