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Pathway Description
Emtricitabine Action Pathway
Homo sapiens
Drug Action Pathway
Created: 2014-06-23
Last Updated: 2019-08-16
Emtricitabine (also known as FTC) is a nucleoside reverse transcriptase inhibitor (NRTI) for treating HIV infection by inhibiting the transcriptase reversibly. Emtricitabine is phosphorylated to form emtricitabine 5'-triphosphate so that emtricitabine 5'-triphosphate can compete with deoxycytidine 5'-triphosphate to inhibit HIV-1 reverse transcriptase, which lead to early chain termination. Emtricitabine 5'-triphosphate can also incorporate into viral DNA to inhibit the activity of HIV-1 reverse transcriptase (RT).
References
Emtricitabine Pathway References
Venhoff N, Setzer B, Melkaoui K, Walker UA: Mitochondrial toxicity of tenofovir, emtricitabine and abacavir alone and in combination with additional nucleoside reverse transcriptase inhibitors. Antivir Ther. 2007;12(7):1075-85.
Pubmed: 18018766
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