SMPDB

Pathway Description

Lamivudine Action Pathway

Homo sapiens

Drug Action Pathway

Created: 2014-06-23

Last Updated: 2025-01-29

Lamivudine (also known as 3TC) is an antiretroviral drug that can be used to treat HIV/AIDS. Lamivudine is phosphorylated to lamivudine triphosphate (L-TP), which is its active metabolite. Lamivudine triphosphate (L-TP) can bind and inhibit the HIV reverse transcriptase as well as HBV polymerase, which lead to DNA chain termination.

References

Lamivudine Pathway References

Caroline M. Perry and Diana Faulds. Lamivudine A Review of its Antiviral Activity, Pharmacokinetic Properties and Therapeutic Efficacy in the Management of HIV Infection. Drugs, April 1997, Volume 53, Issue 4, pp 657–680

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	Lamivudine
	Lamivudine-triphosphate

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