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Pathway Description
Nitrate Reduction VIII
Escherichia coli
Category:
Metabolite Pathway
Sub-Category:
Metabolic
Created: 2015-10-13
Last Updated: 2019-08-13
NADH dehydrogenase and nitrate reductase can form the anaerobic respiratory chain that can be used for transferring electrons from NADH to nitrate with proton-motive force across cytoplasmic membrane. In E. coli K-12, NDH-I and NDH-II is the two energy conserving NADH dehydrogenases that do not contribute to proton gradient; but both of the enzymes are involved in anaerobic nitrate respiration. NDH-I might be acted as proton pump for translocating 4H+ per NADH oxidised (2e-). In E. coli K-12, there are also two energy conserving (H+/e- = 1) nitrate reductases (nitrate reductase A (NRA) and nitrate reductase Z (NRZ)). Nitrate reductase A can express under the condition of high levels of nitrate in environment; while the expression of nitrate reductase Z doesn't depend on nitrate levels or anaerobiosis. Nitrate and hydrogen atom will be catalyzed to form nitrite and water during nitrate reduction.
References
Nitrate Reduction VIII References
Bogachev AV, Murtazina RA, Skulachev VP: H+/e- stoichiometry for NADH dehydrogenase I and dimethyl sulfoxide reductase in anaerobically grown Escherichia coli cells. J Bacteriol. 1996 Nov;178(21):6233-7.
Pubmed: 8892824
Weidner U, Geier S, Ptock A, Friedrich T, Leif H, Weiss H: The gene locus of the proton-translocating NADH: ubiquinone oxidoreductase in Escherichia coli. Organization of the 14 genes and relationship between the derived proteins and subunits of mitochondrial complex I. J Mol Biol. 1993 Sep 5;233(1):109-22. doi: 10.1006/jmbi.1993.1488.
Pubmed: 7690854
Yamamoto Y, Aiba H, Baba T, Hayashi K, Inada T, Isono K, Itoh T, Kimura S, Kitagawa M, Makino K, Miki T, Mitsuhashi N, Mizobuchi K, Mori H, Nakade S, Nakamura Y, Nashimoto H, Oshima T, Oyama S, Saito N, Sampei G, Satoh Y, Sivasundaram S, Tagami H, Horiuchi T, et al.: Construction of a contiguous 874-kb sequence of the Escherichia coli -K12 genome corresponding to 50.0-68.8 min on the linkage map and analysis of its sequence features. DNA Res. 1997 Apr 28;4(2):91-113. doi: 10.1093/dnares/4.2.91.
Pubmed: 9205837
Blattner FR, Plunkett G 3rd, Bloch CA, Perna NT, Burland V, Riley M, Collado-Vides J, Glasner JD, Rode CK, Mayhew GF, Gregor J, Davis NW, Kirkpatrick HA, Goeden MA, Rose DJ, Mau B, Shao Y: The complete genome sequence of Escherichia coli K-12. Science. 1997 Sep 5;277(5331):1453-62. doi: 10.1126/science.277.5331.1453.
Pubmed: 9278503
Zambrano MM, Kolter R: Escherichia coli mutants lacking NADH dehydrogenase I have a competitive disadvantage in stationary phase. J Bacteriol. 1993 Sep;175(17):5642-7. doi: 10.1128/jb.175.17.5642-5647.1993.
Pubmed: 8366049
Pruss BM, Nelms JM, Park C, Wolfe AJ: Mutations in NADH:ubiquinone oxidoreductase of Escherichia coli affect growth on mixed amino acids. J Bacteriol. 1994 Apr;176(8):2143-50. doi: 10.1128/jb.176.8.2143-2150.1994.
Pubmed: 8157582
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