PathBank

Pathway Description

Sedoheptulose Bisphosphate Bypass

Escherichia coli

Category:

Metabolite Pathway

Sub-Category:

Metabolic

Created: 2015-10-13

Last Updated: 2025-05-08

Sedoheptulose bisphospate bypass pathway demonstrates a series of reaction that form D-Erythrose 4-phosphate for pentose phosphate pathway and glycerone phosphate for glycolysis and pyruvate dehydrogenase pathway. D-Sedoheptulose 7-phosphate is obtained from pentose phosphate pathway, which later converted to sedoheptulose 1,7-bisphosphate via 6-phosphofructokinase-1. Fructose-bisphosphate aldolase class 2 catalyzes sedoheptulose 1,7-bisphosphate to form D-Erythrose 4-phosphate and pyruvate dehydrogenase.

References

Sedoheptulose Bisphosphate Bypass References

Nakahigashi K, Toya Y, Ishii N, Soga T, Hasegawa M, Watanabe H, Takai Y, Honma M, Mori H, Tomita M: Systematic phenome analysis of Escherichia coli multiple-knockout mutants reveals hidden reactions in central carbon metabolism. Mol Syst Biol. 2009;5:306. doi: 10.1038/msb.2009.65. Epub 2009 Sep 15.

Pubmed: 19756045

Daldal F: Nucleotide sequence of gene pfkB encoding the minor phosphofructokinase of Escherichia coli K-12. Gene. 1984 Jun;28(3):337-42. doi: 10.1016/0378-1119(84)90151-3.

Pubmed: 6235149

Daldal F: Molecular cloning of the gene for phosphofructokinase-2 of Escherichia coli and the nature of a mutation, pfkB1, causing a high level of the enzyme. J Mol Biol. 1983 Aug 5;168(2):285-305. doi: 10.1016/s0022-2836(83)80019-9.

Pubmed: 6310120

Aiba H, Baba T, Hayashi K, Inada T, Isono K, Itoh T, Kasai H, Kashimoto K, Kimura S, Kitakawa M, Kitagawa M, Makino K, Miki T, Mizobuchi K, Mori H, Mori T, Motomura K, Nakade S, Nakamura Y, Nashimoto H, Nishio Y, Oshima T, Saito N, Sampei G, Horiuchi T, et al.: A 570-kb DNA sequence of the Escherichia coli K-12 genome corresponding to the 28.0-40.1 min region on the linkage map. DNA Res. 1996 Dec 31;3(6):363-77. doi: 10.1093/dnares/3.6.363.

Pubmed: 9097039

Alefounder PR, Perham RN: Identification, molecular cloning and sequence analysis of a gene cluster encoding the class II fructose 1,6-bisphosphate aldolase, 3-phosphoglycerate kinase and a putative second glyceraldehyde 3-phosphate dehydrogenase of Escherichia coli. Mol Microbiol. 1989 Jun;3(6):723-32. doi: 10.1111/j.1365-2958.1989.tb00221.x.

Pubmed: 2546007

Alefounder PR, Baldwin SA, Perham RN, Short NJ: Cloning, sequence analysis and over-expression of the gene for the class II fructose 1,6-bisphosphate aldolase of Escherichia coli. Biochem J. 1989 Jan 15;257(2):529-34. doi: 10.1042/bj2570529.

Pubmed: 2649077

Blattner FR, Plunkett G 3rd, Bloch CA, Perna NT, Burland V, Riley M, Collado-Vides J, Glasner JD, Rode CK, Mayhew GF, Gregor J, Davis NW, Kirkpatrick HA, Goeden MA, Rose DJ, Mau B, Shao Y: The complete genome sequence of Escherichia coli K-12. Science. 1997 Sep 5;277(5331):1453-62. doi: 10.1126/science.277.5331.1453.

Pubmed: 9278503

This pathway was propagated using PathWhiz - Pon, A. et al. Pathways with PathWhiz (2015) Nucleic Acids Res. 43(Web Server issue): W552–W559.

Propagated from SMP0002110

	Adenosine diphosphate
	Adenosine triphosphate
	D-Erythrose 4-phosphate
	D-Sedoheptulose 7-phosphate
	Glycerone phosphate
	Hydrogen Ion
	Sedoheptulose 1,7-bisphosphate

		Adenosine diphosphate
		Adenosine triphosphate
		D-Erythrose 4-phosphate
		D-Sedoheptulose 7-phosphate
		Glycerone phosphate
		Hydrogen Ion
		Sedoheptulose 1,7-bisphosphate

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Sedoheptulose Bisphosphate Bypass

Sedoheptulose Bisphosphate Bypass References