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Pathway Description
Operon: Nucleotide and Deoxyribonucleotide Catabolism Inactivation IV
Escherichia coli
Category:
Protein Pathway
Sub-Categories:
Gene Regulatory
Cellular Response
Created: 2015-11-12
Last Updated: 2019-08-16
The nucleotide and deoxyribonucleotide operon is a polycistronic operon consisting of the genes DeoC, DeoA, DeoB and DeoD. This operon's transcription is activated by Fis DNA-binding transcriptional dual regulator binding to a -102 bp site off the promoter. This operon can also be activated by having CRP-cAMP DNA-binding transcriptional dual regulator binding either to -93.5 or -40.5. The repression of the operon's transcription can be controlled by multiple sites upsteam the promoter: - DeoR (DeoR DNA-binding transcriptional repressor) -887, -309, -8 for promoter deop2 and -609, -8, and 269 for promoter deop1 - CRP-cAMP DNA-binding transcriptional dual regulator binding at -93.5 for promoter deop2 - CytR (CytR DNA-binding transcriptional repressor) -87.5, -70.5, -61 for promoter deop2 -ModE-MoO42- DNA-binding transcriptional dual regulator -35 for promoter deop2
References
Operon: Nucleotide and Deoxyribonucleotide Catabolism Inactivation IV References
Albrechtsen H, Ahmad SI: Regulation of the synthesis of nucleoside catabolic enzymes in Escherichia coli: further analysis of a deo Oc mutant strain. Mol Gen Genet. 1980;179(2):457-60.
Pubmed: 6780756
Amouyal M, Mortensen L, Buc H, Hammer K: Single and double loop formation when deoR repressor binds to its natural operator sites. Cell. 1989 Aug 11;58(3):545-51.
Pubmed: 2667765
Brikun I, Suziedelis K, Stemmann O, Zhong R, Alikhanian L, Linkova E, Mironov A, Berg DE: Analysis of CRP-CytR interactions at the Escherichia coli udp promoter. J Bacteriol. 1996 Mar;178(6):1614-22.
Pubmed: 8626289
Chahla M, Wooll J, Laue TM, Nguyen N, Senear DF: Role of protein-protein bridging interactions on cooperative assembly of DNA-bound CRP-CytR-CRP complex and regulation of the Escherichia coli CytR regulon. Biochemistry. 2003 Apr 8;42(13):3812-25. doi: 10.1021/bi0271143.
Pubmed: 12667072
Gavigan SA, Nguyen T, Nguyen N, Senear DF: Role of multiple CytR binding sites on cooperativity, competition, and induction at the Escherichia coli udp promoter. J Biol Chem. 1999 Jun 4;274(23):16010-9.
Pubmed: 10347150
Gerlach P, Sogaard-Andersen L, Pedersen H, Martinussen J, Valentin-Hansen P, Bremer E: The cyclic AMP (cAMP)-cAMP receptor protein complex functions both as an activator and as a corepressor at the tsx-p2 promoter of Escherichia coli K-12. J Bacteriol. 1991 Sep;173(17):5419-30.
Pubmed: 1715855
Svenningsen BA: Regulated in vitro synthesis of the enzymes of the deo operon of Escerichia coli. properties of the DNA directed system. Mol Gen Genet. 1975;137(4):289-304.
Pubmed: 810659
Valentin-Hansen P, Larsen JE, Hojrup P, Short SA, Barbier CS: Nucleotide sequence of the CytR regulatory gene of E. coli K-12. Nucleic Acids Res. 1986 Mar 11;14(5):2215-28. doi: 10.1093/nar/14.5.2215.
Pubmed: 3515317
Plunkett G 3rd, Burland V, Daniels DL, Blattner FR: Analysis of the Escherichia coli genome. III. DNA sequence of the region from 87.2 to 89.2 minutes. Nucleic Acids Res. 1993 Jul 25;21(15):3391-8. doi: 10.1093/nar/21.15.3391.
Pubmed: 8346018
Blattner FR, Plunkett G 3rd, Bloch CA, Perna NT, Burland V, Riley M, Collado-Vides J, Glasner JD, Rode CK, Mayhew GF, Gregor J, Davis NW, Kirkpatrick HA, Goeden MA, Rose DJ, Mau B, Shao Y: The complete genome sequence of Escherichia coli K-12. Science. 1997 Sep 5;277(5331):1453-62. doi: 10.1126/science.277.5331.1453.
Pubmed: 9278503
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