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solute carrier
family 44 A1
Choline
transporter-
like protein 2
Unknown
Unknown
Choline
dehydrogenase,
mitochondrial
Alpha-
aminoadipic
semialdehyde
dehydrogenase
Betaine--
homocysteine S-
methyltransferase
1
S-
adenosylmethionine
synthase
isoform type-2
Methionine
adenosyltransferase
2 subunit beta
Glycine N-
methyltransferase
Serine
hydroxymethyltransferase,
cytosolic
Dimethylglycine
dehydrogenase,
mitochondrial
Sarcosine
dehydrogenase,
mitochondrial
Serine
hydroxymethyltransferase,
mitochondrial
Methionine
synthase
Choline
Choline
βine
βine
Dimethylglycine
Dimethylglycine
βine aldehyde
NAD
H
2
O
NADH
Homocysteine
L-Methionine
ATP
H
2
O
S-Adenosylmethionine
P
i
PP
i
Sarcosine
S-Adenosylhomocysteine
Glycine
L-Serine
Tetrahydrofolic acid
5,10-Methylene-THF
H
2
O
Tetrahydrofolate
Sarcosine
5-Methyltetrahydrofolic acid
Tetrahydrofolate
5-Methyltetrahydrofolic acid
Glycine
L-Serine
Tetrahydrofolate
5-Methyltetrahydrofolic acid
5-Methyltetrahydrofolic acid
Tetrahydrofolic acid
FAD
Zinc (II) ion
Potassium
FAD
FAD
Acceptor
Reduced
acceptor
Magnesium
Pyridoxal
5'-phosphate
Zinc (II) ion
Methylcobalamin
Pyridoxal
5'-phosphate
Intracellular space
Mitochondrion
Outer Mitochondrial Membrane
Inner Mitochondrial Membrane
Upregulated Expression
Mutant SARDH
Mitochondria
SLC44A1
SLC44A2
Unknown
Unknown
CHDH
ALDH7A1
BHMT
MAT2A
MAT2B
GNMT
SHMT1
DMGDH
SARDH
SHMT2
MTR
Choline
Choline
βine
βine
Dimethylglycine
Dimethylglycine
βine aldehyde
NAD
Water
NADH
Homocysteine
L-Methionine
Adenosine
triphosphate
Water
S-
Adenosylmethionine
Phosphate
Pyrophosphate
Sarcosine
S-
Adenosylhomocysteine
Glycine
L-Serine
Tetrahydrofolic
acid
5,10-
Methylene-THF
Water
Tetrahydrofolate
Sarcosine
5-
Methyltetrahydrofolic
acid
Tetrahydrofolate
5-
Methyltetrahydrofolic
acid
Glycine
L-Serine
Tetrahydrofolate
5-
Methyltetrahydrofolic
acid
5-
Methyltetrahydrofolic
acid
Tetrahydrofolic
acid
Acceptor
Reduced
acceptor