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Malate
dehydrogenase,
mitochondrial
Methylcytosine
dioxygenase
TET1
Lysine-specific
demethylase 2A
Mitochondrial
pyruvate
carrier 1
Mitochondrial
citrate
transport
protein
Pyruvate
dehydrogenase
complex
Citrate
synthase,
mitochondrial
Isocitrate
dehydrogenase
[NAD] subunit
alpha,
mitochondrial
Isocitrate
dehydrogenase
[NAD] subunit
beta,
mitochondrial
Isocitrate
dehydrogenase
[NAD] subunit
gamma,
mitochondrial
Oxoglutarate
dehydrogenase
complex
Succinyl-CoA
ligase
Fumarate
hydratase,
mitochondrial
Pyruvate
carboxylase,
mitochondrial
Succinate
dehydrogenase
Aconitate
hydratase,
mitochondrial
Aconitate
hydratase,
mitochondrial
Glutamate
dehydrogenase
1,
mitochondrial
Glutaminase
liver isoform,
mitochondrial
Cytoplasmic
aconitate
hydratase
Isocitrate
dehydrogenase
[NADP]
cytoplasmic
Isocitrate
dehydrogenase
[NADP],
mitochondrial
L-2-
hydroxyglutarate
dehydrogenase,
mitochondrial
Isocitrate
dehydrogenase
[NADP]
cytoplasmic
mutant
Isocitrate
dehydrogenase 2
[NADP],
mitochondrial
D-2-
hydroxyglutarate
dehydrogenase,
mitochondrial
Pyruvic acid
FADH
2
Pyruvic acid
Citric acid
Citric acid
CoA
NAD
Acetyl-CoA
CO
2
NADH
H
2
O
Oxalacetic acid
CoA
Isocitric acid
NAD
Oxoglutaric acid
CO
2
NADH
H
+
NAD
CoA
Succinyl-CoA
NADH
H
+
CO
2
P
i
GDP
Succinic acid
CoA
GTP
L-Malic acid
Fumaric acid
H
2
O
NAD
NADH
H
+
ATP
HCO
3
-
ADP
P
i
Q
FAD
QH
2
cis-Aconitic acid
H
2
O
H
2
O
NADPH
Ammonium
H
+
L-Glutamic acid
H
2
O
NADP
L-Glutamine
H
2
O
NH
3
Isocitric acid
NADP
Oxoglutaric acid
NADPH
NADP
Oxoglutaric acid
NADPH
NADP
2-Hydroxyglutarate
NADPH
NADPH
D-2-Hydroxyglutaric acid
NADP
NADPH
NADP
NADPH
NADP
Thiamine
pyrophosphate
Lipoamide
FAD
Magnesium
Thiamine
pyrophosphate
Lipoamide
FAD
Biotin
Manganese
Magnesium
FAD
FAD
Glycolysis
Mitochondrial
Electron
Transport Chain
4Fe-4S
4Fe-4S
4Fe-4S
Magnesium
Inner mitochondrial membrane
Mitochondrial intermembrane
space
Cytosol
Mitochondrial matrix
Mitochondrion
Intracellular Space
Inner mitochondrial membrane
Outer mitochondrial membrane
Cytosol
Epigenetic Regulation
Oncogene Activation,
Tumour-suppressor
inactivation
TCA cycle
Citric acid
Isocitric acid
Oxoglutaric acid
D-2-Hydroxyglutaric acid
2-Hydroxyglutarate
Oxoglutaric acid
Isocitrate dehydrogenase
[NADP] cytoplasmic
Cytoplasmic aconitase
hydratase
mutIDH2
D-2-hydroxyglutarate
dehydrogenase, mitochondrial
L-2-hydroxyglutarate
dehydrogenase, mitochondrial
Methylcytosine dioxygenase
TET1
Lysine-specific demethylase
2A