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Cytochrome P450 2C9 Cytochrome P450 2B6 Cytochrome P450 2C19 Cytochrome P450 3A4 Cytochrome P450 2C8 Cytochrome P450 2A6 Retinal dehydrogenase 1 Aldehyde dehydrogenase, dimeric NADP-preferring Retinal dehydrogenase 1 Aldehyde dehydrogenase, dimeric NADP-preferring Glutathione S-transferase Mu 1 Cytochrome P450 3A4 Cytochrome P450 3A4 Aldophosphamide Aldophosphamide 4-Hydroxycyclophosphamide Acrolein Phosphoramide mustard Phosphoramide Aziridinium Cl- Carboxyphosphamide Nornitrogen mustard Cyclophosphamide O2 NADPH H+ H2O NADP NAD H2O Acrylic acid NADH H+ NAD H2O NADH H+ Glutathione 4-Glutathionyl cyclophosphamide H2O O2 H2O Chloroacetaldehyde 3-Dechloroethylifosfamide H2O2 NAD 4-Ketocyclophosphamide NADH Heme Heme Heme Heme Heme Heme Heme Heme Endoplasmic Reticulum Membrane
Endoplasmic Reticulum CYP2C9 CYP2B6 CYP2C19 CYP3A4 CYP2C8 CYP2A6 ALDH1A1 ALDH3A1 ALDH1A1 ALDH3A1 GSTM1 CYP3A4 CYP3A4 Aldophosphamide Aldophosphamide 4- Hydroxycyclophosphamide Acrolein Phosphoramide mustard Phosphoramide Aziridinium Chloride ion Carboxyphosphamide Nornitrogen mustard Cyclophosphamide Oxygen NADPH Hydrogen Ion Water NADP NAD Water Acrylic acid NADH Hydrogen Ion NAD Water NADH Hydrogen Ion Glutathione 4-Glutathionyl cyclophosphamide Water Oxygen Water Chloroacetaldehyde 3- Dechloroethylifosfamide Hydrogen peroxide NAD 4- Ketocyclophosphamide NADH
CYP2C9 CYP2B6 CYP2C19 CYP3A4 CYP2C8 CYP2A6 ALDH1A1 ALDH3A1 ALDH1A1 ALDH3A1 GSTM1 CYP3A4 CYP3A4 Aldoph Aldoph 4HCP Acrolen Phospho PhoAzdm Cl- Caroxyp Nornm Cycloph O2 NADPH H+ H2O NADP NAD H2O AcryliA NADH H+ NAD H2O NADH H+ GSH 4GtyCP H2O O2 H2O chlogl 3DCLFA H2O2 NAD 4KcycPm NADH Heme Heme Heme Heme Heme Heme Heme Heme Endoplasmic Reticulum Membrane
Endoplasmic Reticulum CYP2C9 CYP2B6 CYP2C19 CYP3A4 CYP2C8 CYP2A6 ALDH1A1 ALDH3A1 ALDH1A1 ALDH3A1 GSTM1 CYP3A4 CYP3A4 Aldoph Aldoph 4HCP Acrolen Phospho PhoAzdm Cl Caroxyp Nornm Cycloph O2 NADPH H+ H2O NADP NAD H2O AcryliA NADH H+ NAD H2O NADH H+ GSH 4GtyCP H2O O2 H2O chlogl 3DCLFA H2O2 NAD 4KcycPm NADH