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Phospholipase C, beta 1 Inositol 1,4,5- trisphosphate receptor type 1 protein kinase C beta Nuclear factor NF-kappa-B p105 subunit Histamine H1 receptor Gαq Gαq Histamine H1 receptor Histamine Inositol 1,4,5- trisphosphate Ca+ Ketotifen Ca+ H2O Calcium Calcium GDP GTP Histamine 1,2-diacyl- sn-glycerol phosphatidylinositol 4,5- bisphosphate ↑ Pro-inflammatory Cytokines, Cell Adhesion Molecules, Chemotactic Factors Mast Cells Release Histamine Endoplasmic Reticulum Nucleus Calcium Ion Channel Cell Membrane Cytoplasm ↑ Antigen Presentation ↑ Mediator Release ↓ Mast Cell Stabilization
Endoplasmic Reticulum GNG2 GNB1 PLCB1 ITPR1 PRKCB NFKB1 GNG2 HRH1 GNAQ GNAQ HRH1 GNB1 Histamine Inositol 1,4,5- trisphosphate Calcium Ketotifen Calcium Water Guanosine diphosphate Guanosine triphosphate Histamine 1,2-diacyl- sn-glycerol phosphatidylinositol 4,5- bisphosphate Mast Cells Release Histamine
GNG2 GNB1 PLCB1 ITPR1 PRKCB NFKB1 GNG2 HRH1 GNAQ GNAQ HRH1 GNB1 Hsm Inotp Ca+ Ketotif Ca+ H2O Ca2+ Ca2+ GDP GTP Hsm 12DSG P45B ↑ Pro-inflammatory Cytokines, Cell Adhesion Molecules, Chemotactic Factors M C R H Endoplasmic Reticulum Nucleus Calcium Ion Channel Cell Membrane Cytoplasm ↑ Antigen Presentation ↑ Mediator Release ↓ Mast Cell Stabilization
Endoplasmic Reticulum GNG2 GNB1 PLCB1 ITPR1 PRKCB NFKB1 GNG2 HRH1 GNAQ GNAQ HRH1 GNB1 Hsm Inotp Ca2+ Ketotif Ca2+ H2O GDP GTP Hsm 12DSG P45B M C R H