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Pathway Description
Classical Complement Pathway
Homo sapiens
Protein Pathway
Created: 2018-07-30
Last Updated: 2019-08-16
The classical complement pathway is a pathway that is responsible for activating the complement system within the immune system. This pathway begins with the activation of antibodies IgM and IgG. Protein C3 is created, and after a series of reactions, cleaves the C5 protein. This brings phagocytes to the infected area and sets the stage for the coming together of the membrane attack complex (MAC). This complex targets the cell and creates an opening in the membrane, which leads to cell lysis and death.
References
Classical Complement Pathway References
https://www.qiagen.com/us/shop/genes-and-pathways/pathway-details/?pwid=117
https://cgap.nci.nih.gov/Pathways/BioCarta/h_classicPathway
Ulgiati D, Townend DC, Christiansen FT, Dawkins RL, Abraham LJ: Complete sequence of the complement C4 gene from the HLA-A1, B8, C4AQ0, C4B1, DR3 haplotype. Immunogenetics. 1996;43(4):250-2.
Pubmed: 8575831
Martinez-Quiles N, Paz-Artal E, Moreno-Pelayo MA, Longas J, Ferre-Lopez S, Rosal M, Arnaiz-Villena A: C4d DNA sequences of two infrequent human allotypes (C4A13 and C4B12) and the presence of signal sequences enhancing recombination. J Immunol. 1998 Oct 1;161(7):3438-43.
Pubmed: 9759862
Lopez-Goyanes A, Moreno MA, Ferre S, Paz-Artal E: C4d DNA sequence of complement C4B93 and recombination mechanisms for its generation. Tissue Antigens. 2004 Mar;63(3):260-2. doi: 10.1111/j.0001-2815.2004.00147.x.
Pubmed: 14989716
Yu CY: The complete exon-intron structure of a human complement component C4A gene. DNA sequences, polymorphism, and linkage to the 21-hydroxylase gene. J Immunol. 1991 Feb 1;146(3):1057-66.
Pubmed: 1988494
Sargent CA, Anderson MJ, Hsieh SL, Kendall E, Gomez-Escobar N, Campbell RD: Characterisation of the novel gene G11 lying adjacent to the complement C4A gene in the human major histocompatibility complex. Hum Mol Genet. 1994 Mar;3(3):481-8. doi: 10.1093/hmg/3.3.481.
Pubmed: 8012361
Bentley DR: Primary structure of human complement component C2. Homology to two unrelated protein families. Biochem J. 1986 Oct 15;239(2):339-45. doi: 10.1042/bj2390339.
Pubmed: 2949737
Horiuchi T, Macon KJ, Kidd VJ, Volanakis JE: cDNA cloning and expression of human complement component C2. J Immunol. 1989 Mar 15;142(6):2105-11.
Pubmed: 2493504
Ishii Y, Zhu ZB, Macon KJ, Volanakis JE: Structure of the human C2 gene. J Immunol. 1993 Jul 1;151(1):170-4.
Pubmed: 8326124
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