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Pathway Description
Didanosine Action Pathway
Homo sapiens
Drug Action Pathway
Created: 2014-06-23
Last Updated: 2019-08-16
Didanosine (ddl) can be metabolized into dideoxyadenosine triphosphate (ddATP) by series of reaction. Dideoxyadenosine triphosphate can bind and inhibit HIV reverse transcriptase enzyme competitively against natural dATP. Dideoxyadenosine triphosphate will terminate the viral DNA chain to make it missing 3'-OH group so that formation of 5' to 3' phosphodiester could be prevented, which 5' to 3' phosphodiester is required for DNA chain elongation and result in terminated DNA growth.
References
Didanosine Pathway References
Munir N.Nassar Tracy Chen Michael J.ReffShreeram N.Agharkar. (1993) Didanosine. Analytical Profiles of Drug Substances and Excipients, Volume 22, 1993, Pages 185-227
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