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Bile acid receptor Fibroblast growth factor 19 Basic fibroblast growth factor receptor 1 Fibroblast growth factor receptor 2 Fibroblast growth factor receptor 3 Fibroblast growth factor receptor 4 Beta-klotho Fibroblast growth factor 19 Fibroblast growth factor 19 Ileal sodium/bile acid cotransporter Fibroblast growth factor 19 Bile Acid Bile Acid Bile Acid Blood-Brain Barrier (BBB) Neuron Cell Gallbladder Bile acids are synthesized in the liver and stored in the gallbladder. Following food intake, bile acids are released into the duodenum and travel down the intestine. Enterocyte FGF19 entry into brain is influenced by its serum concentration Activation of FXR by bile acids leads to induction of the FGF-19 gene. FGF-19 is secreted from the hepatocyte Transcription; Translation
NR1H4 FGF19 FGFR1 FGFR2 FGFR3 FGFR4 KLB FGF19 FGF19 SLC10A2 FGF19 Bile Acid Bile Acid Bile Acid
NR1H4 FGF19 FGFR1 FGFR2 FGFR3 FGFR4 KLB FGF19 FGF19 SLC10A2 FGF19 BA BA BA Blood-Brain Barrier (BBB) Neuron Cell Gallbladder Bile acids are synthesized in the liver and stored in the gallbladder. Following food intake, bile acids are released into the duodenum and travel down the intestine. Enterocyte FGF19 entry into brain is influenced by its serum concentration Activation of FXR by bile acids leads to induction of the FGF-19 gene. FGF-19 is secreted from the hepatocyte Transcription; Translation
NR1H4 FGF19 FGFR1 FGFR2 FGFR3 FGFR4 KLB FGF19 FGF19 SLC10A2 FGF19 BA BA BA