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Pathway Description
Excitatory Neural Signalling Through 5-HTR 4 and Serotonin
Rattus norvegicus
Category:
Protein Pathway
Sub-Categories:
Neurological Signaling
Kinase Signaling
Gene Regulatory
Cellular Response
Created: 2018-08-31
Last Updated: 2019-09-13
The 5-HT4 receptor is primarily found in the CNS, GI tract, and PNS. Peripheral receptors have important roles in the function of many organ responses (alimentary tract, urinary bladder, heart, and adrenal gland). Alimentary tract receptors have a role in smooth muscle tone, mucosal electrolyte secretion, and the peristaltic reflex. Urinary bladder receptors control cholinergic/purinergic transmission. Atrial heart receptors produce positive inotropy and tachycardia that can precipitate arrhythmias. This receptor is also thought to have roles in anxiety, appetite, GI motility, learning, memory, mood, and respiration. The 5-HT4 receptor activates G(s) proteins which lead to the activation of adenylyl cyclase which produces the secondary messenger cAMP. cAMP activates PKA (protein kinase A) which phosphorylates downstream effectors that lead to a specific cellular response.
References
Excitatory Neural Signalling Through 5-HTR 4 and Serotonin References
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Pubmed: 1719547
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Pubmed: 7761832
Boran AD, Chen Y, Iyengar R: Identification of new Gbetagamma interaction sites in adenylyl cyclase 2. Cell Signal. 2011 Sep;23(9):1489-95. doi: 10.1016/j.cellsig.2011.05.002. Epub 2011 May 8.
Pubmed: 21596131
Itoh H, Kozasa T, Nagata S, Nakamura S, Katada T, Ui M, Iwai S, Ohtsuka E, Kawasaki H, Suzuki K, et al.: Molecular cloning and sequence determination of cDNAs for alpha subunits of the guanine nucleotide-binding proteins Gs, Gi, and Go from rat brain. Proc Natl Acad Sci U S A. 1986 Jun;83(11):3776-80. doi: 10.1073/pnas.83.11.3776.
Pubmed: 3086867
Jones DT, Reed RR: Molecular cloning of five GTP-binding protein cDNA species from rat olfactory neuroepithelium. J Biol Chem. 1987 Oct 15;262(29):14241-9.
Pubmed: 2820999
Crawford JA, Mutchler KJ, Sullivan BE, Lanigan TM, Clark MS, Russo AF: Neural expression of a novel alternatively spliced and polyadenylated Gs alpha transcript. J Biol Chem. 1993 May 5;268(13):9879-85.
Pubmed: 8486667
Shuntoh H, Sakamoto N, Matsuyama S, Saitoh M, Tanaka C: Molecular structure of the C beta catalytic subunit of rat cAMP-dependent protein kinase and differential expression of C alpha and C beta isoforms in rat tissues and cultured cells. Biochim Biophys Acta. 1992 Jun 15;1131(2):175-80. doi: 10.1016/0167-4781(92)90073-9.
Pubmed: 1610898
Jedrzejewski PT, Girod A, Tholey A, Konig N, Thullner S, Kinzel V, Bossemeyer D: A conserved deamidation site at Asn 2 in the catalytic subunit of mammalian cAMP-dependent protein kinase detected by capillary LC-MS and tandem mass spectrometry. Protein Sci. 1998 Feb;7(2):457-69. doi: 10.1002/pro.5560070227.
Pubmed: 9521123
Lundby A, Secher A, Lage K, Nordsborg NB, Dmytriyev A, Lundby C, Olsen JV: Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues. Nat Commun. 2012 Jun 6;3:876. doi: 10.1038/ncomms1871.
Pubmed: 22673903
Kitamura K, Mizuno Y, Sasaki A, Yasui A, Tsuiki S, Kikuchi K: Molecular cloning and sequence analysis of cDNA for the catalytic subunit 1 alpha of rat kidney type 1 protein phosphatase, and detection of the gene expression at high levels in hepatoma cells and regenerating livers as compared to rat livers. J Biochem. 1991 Feb;109(2):307-10.
Pubmed: 1650776
Sasaki K, Shima H, Kitagawa Y, Irino S, Sugimura T, Nagao M: Identification of members of the protein phosphatase 1 gene family in the rat and enhanced expression of protein phosphatase 1 alpha gene in rat hepatocellular carcinomas. Jpn J Cancer Res. 1990 Dec;81(12):1272-80. doi: 10.1111/j.1349-7006.1990.tb02690.x.
Pubmed: 2177460
da Cruz e Silva EF, Fox CA, Ouimet CC, Gustafson E, Watson SJ, Greengard P: Differential expression of protein phosphatase 1 isoforms in mammalian brain. J Neurosci. 1995 May;15(5 Pt 1):3375-89.
Pubmed: 7751917
Gonzalez GA, Yamamoto KK, Fischer WH, Karr D, Menzel P, Biggs W 3rd, Vale WW, Montminy MR: A cluster of phosphorylation sites on the cyclic AMP-regulated nuclear factor CREB predicted by its sequence. Nature. 1989 Feb 23;337(6209):749-52. doi: 10.1038/337749a0.
Pubmed: 2521922
Short ML, Manohar CF, Furtado MR, Ghadge GD, Wolinsky SM, Thimmapaya B, Jungmann RA: Nucleotide and derived amino-acid sequences of the CRE-binding proteins from rat C6 glioma and HeLa cells. Nucleic Acids Res. 1991 Aug 11;19(15):4290. doi: 10.1093/nar/19.15.4290.
Pubmed: 1831258
Sheng M, Thompson MA, Greenberg ME: CREB: a Ca(2+)-regulated transcription factor phosphorylated by calmodulin-dependent kinases. Science. 1991 Jun 7;252(5011):1427-30. doi: 10.1126/science.1646483.
Pubmed: 1646483
This pathway was propagated using PathWhiz -
Pon, A. et al. Pathways with PathWhiz (2015) Nucleic Acids Res. 43(Web Server issue): W552–W559.
Propagated from SMP0000309
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