PathBank

Pathway Description

EPO Signaling Pathway

Bos taurus

Category:

Protein Pathway

Sub-Categories:

Cytokine Signaling

Kinase Signaling

Gene Regulatory

Cellular Response

Created: 2018-09-20

Last Updated: 2019-08-16

The hormone erythropoietin, is a 166 amino acid protein with an apparent molecular weight in its native form of 39,000 Da. The molecule is heavily glycosylated since its mass derived from its amino acid content is 18,398. The selective interaction of a hormone with its target cells is usually mediated by cell membrane receptors specific for the particular hormone. Erythropoietin-responsive cells have a trypsin-sensitive receptor for the hormone which requires protein synthesis for its maintenance. Erythropoietin-responsive cells can interact with other hematopoietic growth factors, and such interactions may lead to competition for pathway-specific differentiation, particularly under conditions of high cell density. The amino-terminal region of the hormone is not involved in receptor binding.

References

EPO Signaling Pathway References

Seyfert HM, Pitra C, Meyer L, Brunner RM, Wheeler TT, Molenaar A, McCracken JY, Herrmann J, Thiesen HJ, Schwerin M: Molecular characterization of STAT5A- and STAT5B-encoding genes reveals extended intragenic sequence homogeneity in cattle and mouse and different degrees of divergent evolution of various domains. J Mol Evol. 2000 Jun;50(6):550-61.

Pubmed: 10835485

McCracken JY, Molenaar AJ, Snell RJ, Davey HW, Wilkins RJ: A polymorphic TG repeat present within the bovine STAT5A gene. Anim Genet. 1997 Dec;28(6):459.

Pubmed: 9589597

Antoniou E, Hirst BJ, Grosz M, Skidmore CJ: A single strand conformational polymorphism in the bovine gene STAT5A. Anim Genet. 1999 Jun;30(3):232.

Pubmed: 10442998

Suliman HB, Majiwa PA, Feldman BF, Mertens B, Logan-Henfrey L: Cloning of a cDNA encoding bovine erythropoietin and analysis of its transcription in selected tissues. Gene. 1996 Jun 1;171(2):275-80. doi: 10.1016/0378-1119(95)00895-0.

Pubmed: 8666286

Zimin AV, Delcher AL, Florea L, Kelley DR, Schatz MC, Puiu D, Hanrahan F, Pertea G, Van Tassell CP, Sonstegard TS, Marcais G, Roberts M, Subramanian P, Yorke JA, Salzberg SL: A whole-genome assembly of the domestic cow, Bos taurus. Genome Biol. 2009;10(4):R42. doi: 10.1186/gb-2009-10-4-r42. Epub 2009 Apr 24.

Pubmed: 19393038

Stahl ML, Ferenz CR, Kelleher KL, Kriz RW, Knopf JL: Sequence similarity of phospholipase C with the non-catalytic region of src. Nature. 1988 Mar 17;332(6161):269-72. doi: 10.1038/332269a0.

Pubmed: 2831461

Kim JW, Sim SS, Kim UH, Nishibe S, Wahl MI, Carpenter G, Rhee SG: Tyrosine residues in bovine phospholipase C-gamma phosphorylated by the epidermal growth factor receptor in vitro. J Biol Chem. 1990 Mar 5;265(7):3940-3.

Pubmed: 1689310

Wahl MI, Nishibe S, Kim JW, Kim H, Rhee SG, Carpenter G: Identification of two epidermal growth factor-sensitive tyrosine phosphorylation sites of phospholipase C-gamma in intact HSC-1 cells. J Biol Chem. 1990 Mar 5;265(7):3944-8.

Pubmed: 1689311

Yang W, Cerione RA: Cloning and characterization of a novel Cdc42-associated tyrosine kinase, ACK-2, from bovine brain. J Biol Chem. 1997 Oct 3;272(40):24819-24. doi: 10.1074/jbc.272.40.24819.

Pubmed: 9312079

Lin Q, Lo CG, Cerione RA, Yang W: The Cdc42 target ACK2 interacts with sorting nexin 9 (SH3PX1) to regulate epidermal growth factor receptor degradation. J Biol Chem. 2002 Mar 22;277(12):10134-8. doi: 10.1074/jbc.M110329200. Epub 2002 Jan 17.

Pubmed: 11799118

This pathway was propagated using PathWhiz - Pon, A. et al. Pathways with PathWhiz (2015) Nucleic Acids Res. 43(Web Server issue): W552–W559.

Propagated from SMP0069678

Enter relative concentration values (without units). Elements will be highlighted in a color gradient where red = lowest concentration and green = highest concentration. For the best results, view the pathway in Black and White.

Visualize Compound Data

		Calcium
		Guanosine diphosphate
		Guanosine triphosphate
		Magnesium
		Phosphate
		Zinc

Visualize Protein Data

		1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1
		Activated CDC42 kinase 1
		Casein kinase II subunit alpha
		Dual specificity mitogen-activated protein kinase kinase 6
		Erythropoietin
		Erythropoietin receptor
		ETS translocation variant 1
		GRB2-related adapter protein
		Mitogen-activated protein kinase 1
		Mitogen-activated protein kinase 13
		Proto-oncogene c-Fos
		RAF proto-oncogene serine/threonine-protein kinase
		Rap guanine nucleotide exchange factor 2
		Ras-related protein Rap-1b
		Receptor-type tyrosine-protein phosphatase F
		SHC-transforming protein 1
		Signal transducer and activator of transcription 5A
		Transcription factor AP-1