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Renin Amiloride- sensitive sodium channel subunit gamma Urea transporter 2 Urea transporter 2 Band 3 anion transport protein V-type proton ATPase subunit B, kidney isoform Aquaporin-2 Aquaporin-3 Carbonic anhydrase 1 Amiloride- sensitive sodium channel subunit alpha Amiloride- sensitive sodium channel subunit beta Amiloride- sensitive sodium channel subunit delta Aldosterone Na+ Na+ Urea Urea Urea HCO3- HCO3- H+ H+ Na+ K+ K+ H2O H2O H2O H2O CO2 Na+ K+ H2O Urea HCO3- Sodium/potassium- transporting ATPase subunit alpha-1 Sodium/potassium- transporting ATPase subunit alpha-2 Sodium/potassium- transporting ATPase subunit alpha-3 Sodium/potassium- transporting ATPase subunit alpha-4 Sodium/potassium- transporting ATPase subunit beta-2 ATPase, (Na+)/K+ transporting, beta 4 polypeptide Sodium/potassium- transporting ATPase subunit beta-1 Sodium/potassium- transporting ATPase subunit beta-3 Sodium/potassium- transporting ATPase subunit gamma Vasopressin Zinc (II) ion Angiotensin I Angiotensin II Lumen Interstitium Blood Vessel Collecting Duct Vasopressin is released from the posterior pituitary gland into the circulation and reaches the kidneys. Its action on the collecting duct causes an increase in water permeability and subsequent water reabsorption by the body. Aldosterone is released from the adrenal cortex and acts on the collecting duct to make it more permeable to sodium to allow for sodium reuptake by the body. Posterior Pituitary Gland
REN SCNN1G SLC14A2 SLC14A2 SLC4A1 ATP6V1B1 AQP2 AQP3 CA1 SCNN1A SCNN1B SCNN1D Aldosterone Sodium Sodium Urea Urea Urea Hydrogen carbonate Hydrogen carbonate Hydrogen Ion Hydrogen Ion Sodium Potassium Potassium Water Water Water Water Carbon dioxide Sodium Potassium Water Urea Hydrogen carbonate ATP1A1 ATP1A2 ATP1A3 ATP1A4 ATP1B2 Unknown ATP1B1 ATP1B3 FXYD2 Vasopressin Angiotensin I Angiotensin II
REN SCNN1G SLC14A2 SLC14A2 SLC4A1 ATP6V1B1 AQP2 AQP3 CA1 SCNN1A SCNN1B SCNN1D Aldostr Na+ Na+ Urea Urea Urea HCO3- HCO3- H+ H+ Na+ K+ K+ H2O H2O H2O H2O CO2 Na+ K+ H2O Urea HCO3- ATP1A1 ATP1A2 ATP1A3 ATP1A4 ATP1B2 ATP1B1 ATP1B3 FXYD2 ADH Zinc Angio1 Ang II Lumen Interstitium Blood Vessel Collecting Duct Vasopressin is released from the posterior pituitary gland into the circulation and reaches the kidneys. Its action on the collecting duct causes an increase in water permeability and subsequent water reabsorption by the body. Aldosterone is released from the adrenal cortex and acts on the collecting duct to make it more permeable to sodium to allow for sodium reuptake by the body. Posterior Pituitary Gland
REN SCNN1G SLC14A2 SLC14A2 SLC4A1 ATP6V1B1 AQP2 AQP3 CA1 SCNN1A SCNN1B SCNN1D Aldostr Na+ Na+ Urea Urea Urea HCO3 HCO3 H+ H+ Na+ K+ K+ H2O H2O H2O H2O CO2 Na+ K+ H2O Urea HCO3 ATP1A1 ATP1A2 ATP1A3 ATP1A4 ATP1B2 ATP1B1 ATP1B3 FXYD2 ADH Angio1 Ang II