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Acetyl-CoA acetyltransferase, mitochondrial Hydroxymethylglutaryl- CoA synthase, cytoplasmic 3-Hydroxy-3- methylglutaryl- coenzyme A reductase Mevalonate kinase Phosphomevalonate kinase Diphosphomevalonate decarboxylase Isopentenyl- diphosphate Delta-isomerase 1 Farnesyl pyrophosphate synthase Farnesyl pyrophosphate synthase Squalene synthase Squalene monooxygenase Lanosterol synthase Acetyl-CoA Acetoacetyl-CoA CoA H2O 3-Hydroxy-3-methylglutaryl-CoA CoA H+ Mevalonic acid CoA NADP H+ NADPH ATP Mevalonic acid-5P ADP H+ ATP ADP (R)-Mevalonic acid-5-pyrophosphate ATP ADP CO2 Isopentenyl pyrophosphate Pi Dimethylallylpyrophosphate Isopentenyl pyrophosphate Geranyl-PP PPi Isopentenyl pyrophosphate Farnesyl pyrophosphate PPi H+ NADPH PPi NADP Squalene O2 FMNH2 (S)-2,3-Epoxysqualene H+ H2O Flavin Mononucleotide Lanosterol Magnesium Magnesium Magnesium Magnesium FAD Glycolysis Endoplasmic Reticulum Membrane Mitochondria Endoplasmic Reticulum Peroxisome Cytoplasm Nucleus
Endoplasmic Reticulum ACAT1 HMGCS1 HMGCR MVK PMVK MVD IDI1 FDPS FDPS FDFT1 SQLE LSS Acetyl-CoA Acetoacetyl-CoA Coenzyme A Water 3-Hydroxy-3- methylglutaryl- CoA Coenzyme A Hydrogen Ion Mevalonic acid Coenzyme A NADP Hydrogen Ion NADPH Adenosine triphosphate Mevalonic acid-5P Adenosine diphosphate Hydrogen Ion Adenosine triphosphate Adenosine diphosphate (R)-Mevalonic acid-5- pyrophosphate Adenosine triphosphate Adenosine diphosphate Carbon dioxide Isopentenyl pyrophosphate Phosphate Dimethylallylpyrophosphate Isopentenyl pyrophosphate Geranyl-PP Pyrophosphate Isopentenyl pyrophosphate Farnesyl pyrophosphate Pyrophosphate Hydrogen Ion NADPH Pyrophosphate NADP Squalene Oxygen FMNH2 (S)-2,3- Epoxysqualene Hydrogen Ion Water Flavin Mononucleotide Lanosterol Glycolysis
ACAT1 HMGCS1 HMGCR MVK PMVK MVD IDI1 FDPS FDPS FDFT1 SQLE LSS Ac-CoA ActaCoA CoA H2O HMG-CoA CoA H+ Mva CoA NADP H+ NADPH ATP Mvn-5P ADP H+ ATP ADP RMval5P ATP ADP CO2 IsopPyr Pi Ipe IsopPyr Gryl-PP PPi IsopPyr FarPP PPi H+ NADPH PPi NADP Squalen O2 FMNH2 S23O H+ H2O FlvnMnt Lastrol Mg2+ Mg2+ Mg2+ Mg2+ FAD PW000146 Endoplasmic Reticulum Membrane Mitochondria Endoplasmic Reticulum Peroxisome Cytoplasm Nucleus
Endoplasmic Reticulum ACAT1 HMGCS1 HMGCR MVK PMVK MVD IDI1 FDPS FDPS FDFT1 SQLE LSS Ac-CoA ActaCoA CoA H2O HMG-CoA CoA H+ Mva CoA NADP H+ NADPH ATP Mvn-5P ADP H+ ATP ADP RMval5P ATP ADP CO2 IsopPyr Pi Ipe IsopPyr Gryl-PP Ppi IsopPyr FarPP Ppi H+ NADPH Ppi NADP Squalen O2 FMNH2 S23O H+ H2O FlvnMnt Lastrol PW000146