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Lanosterol 14-alpha demethylase Lanosterol 14-alpha demethylase Lanosterol 14-alpha demethylase Lamin-B receptor Methylsterol monooxygenase 1 Methylsterol monooxygenase 1 Methylsterol monooxygenase 1 Sterol-4-alpha- carboxylate 3-dehydrogenase, decarboxylating 3-keto-steroid reductase Methylsterol monooxygenase 1 Methylsterol monooxygenase 1 Methylsterol monooxygenase 1 Sterol-4-alpha- carboxylate 3-dehydrogenase, decarboxylating 3-keto-steroid reductase 3-beta- hydroxysteroid- Delta(8),Delta(7)- isomerase Lathosterol oxidase 7- dehydrocholesterol reductase Delta(24)-sterol reductase Lanosterol O2 FMNH2 4,4-dimethyl- 14α- hydroxymethyl- 5α-cholesta- 8,24-dien-3β-ol Formic acid H2O Flavin Mononucleotide H+ O2 FMNH2 4,4-dimethyl- 14α-formyl-5α- cholesta-8,24- dien-3β-ol Formic acid H2O H+ Flavin Mononucleotide O2 FMNH2 4,4-dimethyl- 5α-cholesta- 8,14,24-trien- 3β-ol Formic acid H2O H+ Flavin Mononucleotide NADPH H+ 4,4-Dimethyl- 5a-cholesta- 8,24-dien-3-b- ol NADP Fe2+ H+ O2 4α- hydroxymethyl- 4β-methyl-5α- cholesta-8,24- dien-3β-ol Fe3+ H2O Fe2+ H+ O2 4α-Formyl-4β- methyl-5α- cholesta-8,24- dien-3β-ol Fe3+ H2O Fe2+ H+ O2 4a-Carboxy-4b- methyl-5a- cholesta-8,24- dien-3b-ol Fe3+ H2O NADP 3-Keto-4- methylzymosterol CO2 NADPH NADP 4a- Methylzymosterol NADPH H+ Fe2+ H+ O2 4α- hydroxymethyl- 5α-cholesta- 8,24-dien-3β-ol Fe3+ H2O Fe2+ H+ O2 4a-Formyl-5a- cholesta-8,24- dien-3b-ol Fe3+ H2O Fe2+ H+ O2 4a-carboxy-5a- cholesta-8,24- dien-3b-ol Fe3+ H2O NADP 5α-cholesta- 8,24-dien-3-one NADPH CO2 NADP Zymosterol H+ NADPH 5a-Cholesta- 7,24-dien-3b-ol Fe2+ H+ O2 7- Dehydrodesmosterol Fe3+ H2O NADP Desmosterol H+ NADPH NADP Cholesterol H+ NADPH Heme Iron Iron Mevalonate Pathway Heme Heme Iron Iron Iron Iron Iron FAD Endoplasmic Reticulum Inner Nuclear Membrane Nucleus Endoplasmic Reticulum Membrane Endoplasmic Reticulum Membrane Outer Nuclear Membrane
Nucleus Endoplasmic Reticulum CYP51A1 CYP51A1 CYP51A1 LBR MSMO1 MSMO1 MSMO1 NSDHL HSD17B7 MSMO1 MSMO1 MSMO1 NSDHL HSD17B7 EBP SC5DL DHCR7 DHCR24 Lanosterol Oxygen FMNH2 4,4-dimethyl- 14α- hydroxymethyl- 5α-cholesta- 8,24-dien-3β-ol Formic acid Water Flavin Mononucleotide Hydrogen Ion Oxygen FMNH2 4,4-dimethyl- 14α-formyl-5α- cholesta-8,24- dien-3β-ol Formic acid Water Hydrogen Ion Flavin Mononucleotide Oxygen FMNH2 4,4-dimethyl- 5α-cholesta- 8,14,24-trien- 3β-ol Formic acid Water Hydrogen Ion Flavin Mononucleotide NADPH Hydrogen Ion 4,4-Dimethyl- 5a-cholesta- 8,24-dien-3-b- ol NADP Fe2+ Hydrogen Ion Oxygen 4α- hydroxymethyl- 4β-methyl-5α- cholesta-8,24- dien-3β-ol Fe3+ Water Fe2+ Hydrogen Ion Oxygen 4α-Formyl-4β- methyl-5α- cholesta-8,24- dien-3β-ol Fe3+ Water Fe2+ Hydrogen Ion Oxygen 4a-Carboxy-4b- methyl-5a- cholesta-8,24- dien-3b-ol Fe3+ Water NADP 3-Keto-4- methylzymosterol Carbon dioxide NADPH NADP 4a- Methylzymosterol NADPH Hydrogen Ion Fe2+ Hydrogen Ion Oxygen 4α- hydroxymethyl- 5α-cholesta- 8,24-dien-3β-ol Fe3+ Water Fe2+ Hydrogen Ion Oxygen 4a-Formyl-5a- cholesta-8,24- dien-3b-ol Fe3+ Water Fe2+ Hydrogen Ion Oxygen 4a-carboxy-5a- cholesta-8,24- dien-3b-ol Fe3+ Water NADP 5α-cholesta- 8,24-dien-3-one NADPH Carbon dioxide NADP Zymosterol Hydrogen Ion NADPH 5a-Cholesta- 7,24-dien-3b-ol Fe2+ Hydrogen Ion Oxygen 7- Dehydrodesmosterol Fe3+ Water NADP Desmosterol Hydrogen Ion NADPH NADP Cholesterol Hydrogen Ion NADPH Mevalonate Pathway
CYP51A1 CYP51A1 CYP51A1 LBR MSMO1 MSMO1 MSMO1 NSDHL HSD17B7 MSMO1 MSMO1 MSMO1 NSDHL HSD17B7 EBP SC5DL DHCR7 DHCR24 Lastrol O2 FMNH2 DMHCOL Formate H2O FlvnMnt H+ O2 FMNH2 DFCDol Formate H2O H+ FlvnMnt O2 FMNH2 DmCTBol Formate H2O H+ FlvnMnt NADPH H+ 44Dcdol NADP Fe2+ H+ O2 hmmcdol Fe3+ H2O Fe2+ H+ O2 fmcol Fe3+ H2O Fe2+ H+ O2 CMCDOL Fe3+ H2O NADP 3K4Mzol CO2 NADPH NADP 4aMzmol NADPH H+ Fe2+ H+ O2 HmCDol Fe3+ H2O Fe2+ H+ O2 45aFC3b Fe3+ H2O Fe2+ H+ O2 4C5C8D3 Fe3+ H2O NADP 5aChone NADPH CO2 NADP Zymstol H+ NADPH 5CDBol Fe2+ H+ O2 7-DHMOL Fe3+ H2O NADP Desmost H+ NADPH NADP Lanol H+ NADPH Heme Iron Iron PW122323 Heme Heme Iron Iron Iron Iron Iron FAD Endoplasmic Reticulum Inner Nuclear Membrane Nucleus Endoplasmic Reticulum Membrane Endoplasmic Reticulum Membrane Outer Nuclear Membrane
Nucleus Endoplasmic Reticulum CYP51A1 CYP51A1 CYP51A1 LBR MSMO1 MSMO1 MSMO1 NSDHL HSD17B7 MSMO1 MSMO1 MSMO1 NSDHL HSD17B7 EBP SC5DL DHCR7 DHCR24 Lastrol O2 FMNH2 DMHCOL Formate H2O FlvnMnt H+ O2 FMNH2 DFCDol Formate H2O H+ FlvnMnt O2 FMNH2 DmCTBol Formate H2O H+ FlvnMnt NADPH H+ 44Dcdol NADP Fe2+ H+ O2 hmmcdol Fe3+ H2O Fe2+ H+ O2 fmcol Fe3+ H2O Fe2+ H+ O2 CMCDOL Fe3+ H2O NADP 3K4Mzol CO2 NADPH NADP 4aMzmol NADPH H+ Fe2+ H+ O2 HmCDol Fe3+ H2O Fe2+ H+ O2 45aFC3b Fe3+ H2O Fe2+ H+ O2 4C5C8D3 Fe3+ H2O NADP 5aChone NADPH CO2 NADP Zymstol H+ NADPH 5CDBol Fe2+ H+ O2 7-DHMOL Fe3+ H2O NADP Desmost H+ NADPH NADP Lanol H+ NADPH PW122323