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Lanosterol
14-alpha
demethylase
Lanosterol
14-alpha
demethylase
Lanosterol
14-alpha
demethylase
Lamin-B receptor
Methylsterol
monooxygenase 1
Methylsterol
monooxygenase 1
Methylsterol
monooxygenase 1
Sterol-4-alpha-
carboxylate
3-dehydrogenase,
decarboxylating
3-keto-steroid
reductase
Methylsterol
monooxygenase 1
Methylsterol
monooxygenase 1
Methylsterol
monooxygenase 1
Sterol-4-alpha-
carboxylate
3-dehydrogenase,
decarboxylating
3-keto-steroid
reductase
3-beta-
hydroxysteroid-
Delta(8),Delta(7)-
isomerase
Lathosterol
oxidase
7-
dehydrocholesterol
reductase
Delta(24)-sterol
reductase
Lanosterol
O
2
FMNH2
4,4-dimethyl-
14α-
hydroxymethyl-
5α-cholesta-
8,24-dien-3β-ol
Formic acid
H
2
O
Flavin
Mononucleotide
H
+
O
2
FMNH2
4,4-dimethyl-
14α-formyl-5α-
cholesta-8,24-
dien-3β-ol
Formic acid
H
2
O
H
+
Flavin
Mononucleotide
O
2
FMNH2
4,4-dimethyl-
5α-cholesta-
8,14,24-trien-
3β-ol
Formic acid
H
2
O
H
+
Flavin
Mononucleotide
NADPH
H
+
4,4-Dimethyl-
5a-cholesta-
8,24-dien-3-b- ol
NADP
Fe2+
H
+
O
2
4α-
hydroxymethyl-
4β-methyl-5α-
cholesta-8,24-
dien-3β-ol
Fe3+
H
2
O
Fe2+
H
+
O
2
4α-Formyl-4β-
methyl-5α-
cholesta-8,24-
dien-3β-ol
Fe3+
H
2
O
Fe2+
H
+
O
2
4a-Carboxy-4b-
methyl-5a-
cholesta-8,24-
dien-3b-ol
Fe3+
H
2
O
NADP
3-Keto-4-
methylzymosterol
CO
2
NADPH
NADP
4a-
Methylzymosterol
NADPH
H
+
Fe2+
H
+
O
2
4α-
hydroxymethyl-
5α-cholesta-
8,24-dien-3β-ol
Fe3+
H
2
O
Fe2+
H
+
O
2
4a-Formyl-5a-
cholesta-8,24-
dien-3b-ol
Fe3+
H
2
O
Fe2+
H
+
O
2
4a-carboxy-5a-
cholesta-8,24-
dien-3b-ol
Fe3+
H
2
O
NADP
5α-cholesta-
8,24-dien-3-one
NADPH
CO
2
NADP
Zymosterol
H
+
NADPH
5a-Cholesta-
7,24-dien-3b-ol
Fe2+
H
+
O
2
7-
Dehydrodesmosterol
Fe3+
H
2
O
NADP
Desmosterol
H
+
NADPH
NADP
Cholesterol
H
+
NADPH
Heme
Iron
Iron
Mevalonate
Pathway
Heme
Heme
Iron
Iron
Iron
Iron
Iron
FAD
Endoplasmic Reticulum
Inner Nuclear Membrane
Nucleus
Endoplasmic Reticulum
Membrane
Endoplasmic Reticulum
Membrane
Outer Nuclear Membrane