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Liver
carboxylesterase
1
Cytidine
deaminase
Thymidine
phosphorylase
Cytochrome
P450 2A6
Dihydropyrimidine
dehydrogenase
[NADP(+)]
Uridine 5'-
monophosphate
synthase
Uridine
phosphorylase
2
Uridine-
cytidine
kinase-like 1
Thymidine
phosphorylase
Thymidine
kinase,
cytosolic
UMP-CMP kinase
UMP-CMP kinase
Ribonucleoside-
diphosphate
reductase
large subunit
Ribonucleoside-
diphosphate
reductase
subunit M2
Nucleoside
diphosphate
kinase 6
Nucleoside
diphosphate
kinase 6
Deoxyuridine
5'-triphosphate
nucleotidohydrolase,
mitochondrial
Dihydropyrimidinase
Beta-
ureidopropionase
α-Fluoro-β-
alanine
Capecitabine
H
2
O
5'-Deoxy-5-
fluorocytidine
1-Pentanol
CO
2
H
2
O
5'-Deoxy-5-
fluorouridine
NH
3
P
i
Fluorouracil
5-
Deoxyribose-
1-phosphate
Tegafur
O
2
H
2
O
Succinic
aldehyde
NADPH
H
+
5,6-Dihydro-
5-
fluorouracil
NADP
Phosphoribosyl
pyrophosphate
5-Fluorouridine
monophosphate
PP
i
Ribose
1-phosphate
5-Fluorouridine
P
i
ATP
ADP
Deoxyribose
1-phosphate
Floxuridine
P
i
ATP
5-
Fluorodeoxyuridine
monophosphate
ADP
ATP
ADP
5-
Fluorodeoxyuridine
diphosphate
ATP
ADP
5-Fluorouridine
diphosphate
H
2
O
ATP
ADP
5-Fluorouridine
triphosphate
ATP
ADP
5-
Fluorodeoxyuridine
triphosphate
H
2
O
PP
i
H
2
O
α-Fluoro-β-
ureidopropionic
acid
H
2
O
CO
2
NH
3
FAD
Heme
FAD
Flavin
Mononucleotide
Magnesium
Magnesium
Fe3+
Magnesium
Magnesium
Magnesium
Zinc (II) ion
Zinc (II) ion
[Reduced
NADPH---
hemoprotein
reductase]
[Oxidized
NADPH---
hemoprotein
reductase]
Thioredoxin
Thioredoxin
disulfide
Excretion
Endoplasmic Reticulum
Endoplasmic Reticulum
Mitochondrion
Mitochondrion
Cytosol