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Pathway Description
Glutathione Metabolism
Pseudomonas aeruginosa
Category:
Metabolite Pathway
Sub-Category:
Metabolic
Created: 2019-08-12
Last Updated: 2019-09-15
The biosynthesis of glutathione starts with the introduction of L-glutamic acid through either a glutamate:sodium symporter, glutamate / aspartate : H+ symporter GltP or a
glutamate / aspartate ABC transporter. Once in the cytoplasm, L-glutamice acid reacts with L-cysteine through an ATP glutamate-cysteine ligase resulting in gamma-glutamylcysteine. This compound reacts which Glycine through an ATP driven glutathione synthetase thus catabolizing Glutathione.
This compound is metabolized through a spontaneous reaction with an oxidized glutaredoxin resulting in a reduced glutaredoxin and an oxidized glutathione. This compound is reduced by a NADPH glutathione reductase resulting in a glutathione.
Glutathione can then be degraded into various different glutathione containing compounds by reacting with a napthalene or Bromobenzene-2,3-oxide through a glutathione S-transferase.
References
Glutathione Metabolism References
Perry AC, Ni Bhriain N, Brown NL, Rouch DA: Molecular characterization of the gor gene encoding glutathione reductase from Pseudomonas aeruginosa: determinants of substrate specificity among pyridine nucleotide-disulphide oxidoreductases. Mol Microbiol. 1991 Jan;5(1):163-71.
Pubmed: 1849605
Stover CK, Pham XQ, Erwin AL, Mizoguchi SD, Warrener P, Hickey MJ, Brinkman FS, Hufnagle WO, Kowalik DJ, Lagrou M, Garber RL, Goltry L, Tolentino E, Westbrock-Wadman S, Yuan Y, Brody LL, Coulter SN, Folger KR, Kas A, Larbig K, Lim R, Smith K, Spencer D, Wong GK, Wu Z, Paulsen IT, Reizer J, Saier MH, Hancock RE, Lory S, Olson MV: Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic pathogen. Nature. 2000 Aug 31;406(6799):959-64. doi: 10.1038/35023079.
Pubmed: 10984043
Nishijyo T, Park SM, Lu CD, Itoh Y, Abdelal AT: Molecular characterization and regulation of an operon encoding a system for transport of arginine and ornithine and the ArgR regulatory protein in Pseudomonas aeruginosa. J Bacteriol. 1998 Nov;180(21):5559-66.
Pubmed: 9791103
Park SM, Lu CD, Abdelal AT: Cloning and characterization of argR, a gene that participates in regulation of arginine biosynthesis and catabolism in Pseudomonas aeruginosa PAO1. J Bacteriol. 1997 Sep;179(17):5300-8. doi: 10.1128/jb.179.17.5300-5308.1997.
Pubmed: 9286980
Valentini M, Storelli N, Lapouge K: Identification of C(4)-dicarboxylate transport systems in Pseudomonas aeruginosa PAO1. J Bacteriol. 2011 Sep;193(17):4307-16. doi: 10.1128/JB.05074-11. Epub 2011 Jul 1.
Pubmed: 21725012
Yan J, Deforet M, Boyle KE, Rahman R, Liang R, Okegbe C, Dietrich LEP, Qiu W, Xavier JB: Bow-tie signaling in c-di-GMP: Machine learning in a simple biochemical network. PLoS Comput Biol. 2017 Aug 2;13(8):e1005677. doi: 10.1371/journal.pcbi.1005677. eCollection 2017 Aug.
Pubmed: 28767643
Yao X, He W, Lu CD: Functional characterization of seven gamma-Glutamylpolyamine synthetase genes and the bauRABCD locus for polyamine and beta-Alanine utilization in Pseudomonas aeruginosa PAO1. J Bacteriol. 2011 Aug;193(15):3923-30. doi: 10.1128/JB.05105-11. Epub 2011 May 27.
Pubmed: 21622750
This pathway was propagated using PathWhiz -
Pon, A. et al. Pathways with PathWhiz (2015) Nucleic Acids Res. 43(Web Server issue): W552–W559.
Propagated from SMP0000853
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