PathBank

Pathway Description

Secondary Metabolites: Shikimate Pathway

Pseudomonas aeruginosa

Category:

Metabolite Pathway

Sub-Category:

Metabolic

Created: 2019-08-12

Last Updated: 2019-08-16

The biosynthesis of shikimate starts with D-Erythrose-4-phosphate getting transformed into 3-deoxy-D-arabino-heptulosonate-7-phosphate through a phospho-2-dehydro-3-deoxyheptonate aldolase. This is followed by a 3-dehydroquinate synthase converting the 3-deoxy-D-arabino-heptulosonate-7-phosphate into a 3-dehydroquinate which in turn is conveted to 3-dehydroshikimate through a 3-dehydroquinate dehydratase. A this point 3-dehydroshikimate can be turned into Shikimic acid through 2 different reactions involving an NADPH driven Quinate/shikimate dehydrogenase or a NADPH driven shikimate dehydrogenase 2. Shikimate can also be transported through a shikimate:H+ symporter.

References

Secondary Metabolites: Shikimate Pathway References

Yan J, Deforet M, Boyle KE, Rahman R, Liang R, Okegbe C, Dietrich LEP, Qiu W, Xavier JB: Bow-tie signaling in c-di-GMP: Machine learning in a simple biochemical network. PLoS Comput Biol. 2017 Aug 2;13(8):e1005677. doi: 10.1371/journal.pcbi.1005677. eCollection 2017 Aug.

Pubmed: 28767643

Stover CK, Pham XQ, Erwin AL, Mizoguchi SD, Warrener P, Hickey MJ, Brinkman FS, Hufnagle WO, Kowalik DJ, Lagrou M, Garber RL, Goltry L, Tolentino E, Westbrock-Wadman S, Yuan Y, Brody LL, Coulter SN, Folger KR, Kas A, Larbig K, Lim R, Smith K, Spencer D, Wong GK, Wu Z, Paulsen IT, Reizer J, Saier MH, Hancock RE, Lory S, Olson MV: Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic pathogen. Nature. 2000 Aug 31;406(6799):959-64. doi: 10.1038/35023079.

Pubmed: 10984043

This pathway was propagated using PathWhiz - Pon, A. et al. Pathways with PathWhiz (2015) Nucleic Acids Res. 43(Web Server issue): W552–W559.

Propagated from SMP0001001

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Visualize Compound Data

		3-Dehydroquinate
		3-dehydroshikimate
		3-deoxy-D-arabino-heptulosonate-7-phosphate
		D-Erythrose 4-phosphate
		Hydrogen Ion
		NADP
		NADPH
		Phosphate
		Phosphoenolpyruvic acid
		Shikimic acid
		Water

Visualize Protein Data

		3-dehydroquinate synthase
		3-deoxy-7-phosphoheptulonate synthase
		dTDP-4-dehydrorhamnose reductase
		MFS transporter
		Phospho-2-dehydro-3-deoxyheptonate aldolase
		Shikimate dehydrogenase
		Shikimate dehydrogenase (NADP(+))