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Pathway Description
Enterobactin Biosynthesis
Pseudomonas aeruginosa
Category:
Metabolite Pathway
Sub-Category:
Metabolic
Created: 2019-08-12
Last Updated: 2019-08-16
Enterobactin (also known as Enterochelin) is produced by enterobacteria such as Escherichia coli and Salmonella typhimurium. Under iron-deficient condtion, enterobactin can be synthesized and excreted into environment to bind Fe(III). Chorismate is the starting compound for enterobactin biosynthesis, and it can be obtained from chorismate biosynthesis pathway. Isochorismate synthase catalyzes chorismate to form isochorismate, and further breaking down to form (2S,3S)-2,3-dihydroxy-2,3-dihydrobenzoate and pyruvic acid by same synthase enzyme. (2S,3S)-2,3-dihydroxy-2,3-dihydrobenzoate is converted to 2,3-Dihydroxybenzoic acid by 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase. The later synthesis of enterobactin is catalyzed from 2,3-dihydroxybenzoate and L-serine.
References
Enterobactin Biosynthesis References
Serino L, Reimmann C, Baur H, Beyeler M, Visca P, Haas D: Structural genes for salicylate biosynthesis from chorismate in Pseudomonas aeruginosa. Mol Gen Genet. 1995 Nov 15;249(2):217-28. doi: 10.1007/bf00290369.
Pubmed: 7500944
Stover CK, Pham XQ, Erwin AL, Mizoguchi SD, Warrener P, Hickey MJ, Brinkman FS, Hufnagle WO, Kowalik DJ, Lagrou M, Garber RL, Goltry L, Tolentino E, Westbrock-Wadman S, Yuan Y, Brody LL, Coulter SN, Folger KR, Kas A, Larbig K, Lim R, Smith K, Spencer D, Wong GK, Wu Z, Paulsen IT, Reizer J, Saier MH, Hancock RE, Lory S, Olson MV: Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic pathogen. Nature. 2000 Aug 31;406(6799):959-64. doi: 10.1038/35023079.
Pubmed: 10984043
Mavrodi DV, Bonsall RF, Delaney SM, Soule MJ, Phillips G, Thomashow LS: Functional analysis of genes for biosynthesis of pyocyanin and phenazine-1-carboxamide from Pseudomonas aeruginosa PAO1. J Bacteriol. 2001 Nov;183(21):6454-65. doi: 10.1128/JB.183.21.6454-6465.2001.
Pubmed: 11591691
Recinos DA, Sekedat MD, Hernandez A, Cohen TS, Sakhtah H, Prince AS, Price-Whelan A, Dietrich LE: Redundant phenazine operons in Pseudomonas aeruginosa exhibit environment-dependent expression and differential roles in pathogenicity. Proc Natl Acad Sci U S A. 2012 Nov 20;109(47):19420-5. doi: 10.1073/pnas.1213901109. Epub 2012 Nov 5.
Pubmed: 23129634
Kutchma AJ, Hoang TT, Schweizer HP: Characterization of a Pseudomonas aeruginosa fatty acid biosynthetic gene cluster: purification of acyl carrier protein (ACP) and malonyl-coenzyme A:ACP transacylase (FabD). J Bacteriol. 1999 Sep;181(17):5498-504.
Pubmed: 10464226
Serino L, Reimmann C, Visca P, Beyeler M, Chiesa VD, Haas D: Biosynthesis of pyochelin and dihydroaeruginoic acid requires the iron-regulated pchDCBA operon in Pseudomonas aeruginosa. J Bacteriol. 1997 Jan;179(1):248-57. doi: 10.1128/jb.179.1.248-257.1997.
Pubmed: 8982005
This pathway was propagated using PathWhiz -
Pon, A. et al. Pathways with PathWhiz (2015) Nucleic Acids Res. 43(Web Server issue): W552–W559.
Propagated from SMP0002062
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